Results 81 to 90 of about 22,237 (207)

Metabolic Syndrome: From Mechanisms to Therapeutic Interventions

open access: yesMedComm, Volume 7, Issue 9, September 2026.
A comprehensive overview of molecular mechanisms delves into the potential disease mechanisms of metabolic syndrome, including complex mechanisms such as insulin resistance, chronic low‐grade inflammation, oxidative stress, and epigenetic modifications, and how these mechanisms contribute to the development of metabolic syndrome. Here, the relationship
Mengyao Yan, Qian Xiang
wiley   +1 more source

Voice Quality in Individuals With Acquired Immunodeficiency Syndrome

open access: yesInternational Journal of Language &Communication Disorders, Volume 61, Issue 5, September/October 2026.
ABSTRACT Background Speech and voice disorders are frequently observed in individuals with acquired immunodeficiency syndrome (AIDS). However, the literature lacks detailed descriptions of how perceptual and acoustic characteristics manifest in the voice quality profiles of this population.
Vanessa Medina   +4 more
wiley   +1 more source

In Vivo Base Editing Partially Rescues Bone Dysplasia in a Mouse Model of Hutchinson‐Gilford Progeria Syndrome

open access: yesAging Cell, Volume 25, Issue 9, September 2026.
Hutchinson‐Gilford progeria syndrome (HGPS) is a premature aging disorder caused by a mutation in LMNA that produces the toxic progerin protein. In this study, an adenine base editor delivered via AAV9 achieved partial gene correction in HGPS mice when given at two weeks of age, partially rescuing bone structural and gene expression parameters and ...
Wayne A. Cabral   +17 more
wiley   +1 more source

Loving ACTion: An evaluation of an ACT‐based audio podcast intervention focussed on romantic and intimate relationships for adults with visible differences

open access: yesBritish Journal of Health Psychology, Volume 31, Issue 3, September 2026.
Abstract Objectives Research suggests that some adults with visible differences may experience challenges related to romantic relationships, sex and physical intimacy. Loving ACTion is a self‐guided Acceptance and Commitment Therapy (ACT)‐based intervention delivered as an audio podcast series, co‐produced with adults with visible differences and ...
Maia Thornton   +6 more
wiley   +1 more source

Tackling aging and chronic disease: How space exploration and the ‘chameleon effect’ of pharmaceuticals can lead the way

open access: yesExperimental Physiology, Volume 111, Issue 9, Page 4064-4072, 1 September 2026.
Abstract A common misconception surrounding space exploration is that humanity's pursuit of interplanetary travel, such as missions to Mars, is an escape from Earth. In reality, this endeavour offers an invaluable opportunity to address critical biomedical challenges here at home.
Carina Kern, Tina Woods, Keith Siew
wiley   +1 more source

Body composition and lipodystrophy in prepubertal HIV-infected children

open access: yesBrazilian Journal of Infectious Diseases, 2013
Objective: To identify lipodystrophy in prepubertal HIV-infected children using anthropometric parameters and body composition assessment. Methods: Cross-sectional study including 40 prepubertal HIV-infected children of both genders seen at the Care ...
Cecilia Zanin Palchetti   +5 more
doaj   +1 more source

Prevalence of lipodystrophy associated with human recombinant insulin

open access: yesJournal of Mazandaran University of Medical Sciences, 2008
Background and Purpose: Lipodystrophy is potentially a clinical adverse effect, associated with insulin therapy and is believed that usage of human recombinant insulin’s is associated with decreasing prevalence of Lipodystrophy.
S. Akbarzadeh   +3 more
doaj  

A series of genetically confirmed congenital lipodystrophy and diabetes in adult southern Indian patients

open access: yesScientific Reports
In this study, we analysed the mutation spectrum in subjects with suspected lipodystrophy using a targeted Next-generation sequencing (NGS) approach. Subjects with suspected lipodystrophy were for screened six genes (AGPAT2, BSCL2, LMNA, PPARG, ZMPSTE24,
Remya Rajan   +8 more
doaj   +1 more source

Does lipodystrophy affect adherence? The cross-sectional GRAAL study

open access: yes, 2001
Previous studies have shown that patients evaluation of lipodystrophy and measurements of adherence is accurate. The cross sectional GRAAL study aims at analysing the impact of lipodystrophy on drug adherence, measured by self-assessment ...
Della Loggia P.   +14 more
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