Results 61 to 70 of about 22,237 (207)
Plant Biotechnology Journal, EarlyView.ABSTRACT As a major commercial legume crop, soybean ranks among the world's most significant sources of edible oil and plant protein. We previously identified a SEIPIN homologue (FA9) at the fatty acid 9 locus that promotes fatty acid accumulation in soybean.
Hui Li +14 more
wiley +1 more source
Do non-nucleoside reverse transcriptase inhibitors contribute to lipodystrophy? [PDF]
, 2005 Lipodystrophy complications, including lipoatrophy (pathological fat loss) and metabolic complications, have emerged as important long-term toxicities associated with antiretroviral therapy in the current era. The wealth of data that has accumulated over
Nolan, D.
core
The Journal of Physiology, EarlyView.Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney +4 more
wiley +1 more source
Combination antiretroviral therapy -associated lipodystrophy : insights into pathogenesis and treatment [PDF]
, 2011 Introduction: Combination antiretroviral therapy (cART) has decreased morbidity and mortality of individuals infected with human immunodeficiency virus type 1 (HIV-1). Its use, however, is associated with adverse effects which increase the patients risk
Sevastianova, Ksenia
core
Genotype-stratified treatment for monogenic insulin resistance: a systematic review
Communications Medicine, 2023 Background Monogenic insulin resistance (IR) includes lipodystrophy and disorders of insulin signalling. We sought to assess the effects of interventions in monogenic IR, stratified by genetic aetiology.
Robert K. Semple +4 more
doaj +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 8801-8811, October 2026.ABSTRACT Achieving glucose targets without hypoglycaemia is the treatment goal in type 1 diabetes. Structured education, intensified insulin injection regimens, continuous glucose monitoring, automated insulin delivery, and ongoing support from a multidisciplinary team all support people with type 1 diabetes to achieve this goal. Despite these advances,
Nick Oliver +4 more
wiley +1 more source
Complications of lipodystrophy syndromes
, 2021 Lipodystrophy syndromes are rare complex multisystem disorders caused by generalized or partial lack of adipose tissue. Adipose tissue dysfunction in lipodystrophy is associated with leptin deficiency.
Akinci, Gulcin +2 more
core +1 more source
Refining the Genetic Contribution to Type 2 Diabetes Subtypes
Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9450-9460, October 2026.ABSTRACT Background Type 2 diabetes (T2D) is a complex and highly heterogeneous disease driven in part by genetic predisposition and can be stratified into clinical subgroups to aid disease management. We recently grouped T2D subjects in the Qatar Biobank (QBB) cohort into Severe Insulin‐Deficient Diabetes (SIDD), Severe Insulin‐Resistant Diabetes ...
Nayra M. Al‐Thani +5 more
wiley +1 more source
PLIN1 haploinsufficiency is not associated with lipodystrophy
, 2018 Context: Monogenic partial lipodystrophy is a genetically heterogenous disease where only variants with specific genetic mechanisms are causative. Three heterozygous protein extending frameshift variants in PLIN1 have been reported to cause a phenotype ...
SE Flanagan (21320006) +10 more
core +6 more sources
Journal of Medical Case Reports, 2008 Introduction Acquired partial lipodystrophy or Barraquer-Simons syndrome is a rare form of progressive lipodystrophy. The etiopathogenesis of adipose tissue atrophy in these patients is unknown.
Guallar Jordi P +9 more
doaj +1 more source