Results 71 to 80 of about 30,524 (205)

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Anatomic Fat Depots and Coronary Plaque Among Human Immunodeficiency Virus-Infected and Uninfected Men in the Multicenter AIDS Cohort Study. [PDF]

, 2016
Methods.  In a cross-sectional substudy of the Multicenter AIDS Cohort Study, noncontrast cardiac computed tomography (CT) scanning for coronary artery calcium (CAC) scoring was performed on all men, and, for men with normal renal function, coronary CT ...
Brown, Todd T, Budoff, Matthew, Jacobson, Lisa P, Kingsley, Lawrence, Li, Xiuhong, McKibben, Rebeccah, Palella, Frank J, Post, Wendy S, Witt, Mallory D   +8 more
core   +1 more source

Insulin-like growth factors and related proteins in plasma and cerebrospinal fluids of HIV-positive individuals. [PDF]

, 2015
BackgroundClinically significant dysregulation of the insulin-like growth factor (IGF) family proteins occurs in HIV-infected individuals, but the details including whether the deficiencies in IGFs contribute to CNS dysfunction are unknown.MethodsWe ...
Choi, Namjong, Lee, Sunhee C, Letendre, Scott, Lo, Yungtai, Suh, Hyeon-Sook   +4 more
core   +2 more sources

Marfan Syndrome Associated With Intellectual Disability and Behavioral Anomalies: Further Evidence for the Effect of Compound Heterozygous Variants in FBN1 on Phenotypic Severity

American Journal of Medical Genetics Part A, Volume 200, Issue 5, Page 1021-1035, May 2026.
ABSTRACT Marfan syndrome (MFS) is a rare connective tissue disorder characterized by involvement of the cardiovascular, ocular, and musculoskeletal systems. Pathogenic variants in FBN1 cause most of the MFS cases; however, intellectual disability (ID) is rarely observed. A non‐consanguineous Pakistani family with four affected individuals was recruited.
Azmatullah Khan, Naseebullah Kakar, Ainullah Kakar, Malte Spielmann, Sajid Malik   +4 more
wiley   +1 more source

Dyslipidemia and nutritional status in patients HIV positive with Syndrome Lipodystrophy.

Revista de Epidemiologia e Controle de Infecção, 2014
Backgound and Objectives: Lipodystrophy in HIV is adversely affect the antiretroviral therapy (HAART), characterized by redistribution of body fat, as well as metabolic changes related to lipid profile, risk factor associated with increased ...
Isameriliam Rosaulem Pereira da Silva, Rosa Maria Dias, Andreza de Nazaré Leão Mendes, Rosana Maria Feio Libonati, Claudia Daniele Tavares Dutra   +4 more
doaj   +1 more source

Accelerated aging in perinatally HIV-infected children: clinical manifestations and pathogenetic mechanisms [PDF]

, 2018
BACKGROUND: Premature aging and related diseases have been documented in HIV-infected adults. Data are now emerging also regarding accelerated aging process in HIV-infected children. METHODS: A narrative review was performed searching studies on PubMed
Bianconi, Martina, Chiappini, Elena, Dalzini, Annalisa, De Rossi, Anita, Galli, Luisa, Giaquinto, Carlo, Petrara, Maria Raffaella   +6 more
core   +1 more source

Adipose Tissue‐Targeted Delivery of Rosiglitazone With Iron Oxide Nanoparticles Ameliorates Insulin Resistance in Male Mice

Obesity, Volume 34, Issue 5, Page 1068-1080, May 2026.
ABSTRACT Objective This study aimed to assess iron oxide magnetic nanoparticles (MNPs) for adipose tissue‐targeted therapeutics to restore adipose tissue function and insulin sensitivity in obesity. Methods The insulin‐sensitizing effects of rosiglitazone and known adverse effects were leveraged for this proof‐of‐concept assessment of adipose tissue ...
Jakob E. Ostberg, Zeeshan Ahmed, Katayoun Saatchi, Parleen K. Pandher, Yamna Rahim, Urs O. Häfeli, Sarah L. Gray   +6 more
wiley   +1 more source

What determines health-related quality of life among people living with HIV : an updated review of the literature [PDF]

, 2014
Background: As infection with the Human Immunodeficiency Virus (HIV) has evolved to a chronic disease, perceived health-related quality of life (HRQoL) is becoming a prominent and important patient-reported outcome measure in HIV care.
Degroote, Sophie, Vandijck, Dominique, Vogelaers, Dirk   +2 more
core   +2 more sources

Opening closed inward rectifier potassium channel doors

British Journal of Pharmacology, Volume 183, Issue 10, Page 2197-2218, May 2026.
Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger, Fabian Kaiser, Marcel A. G. van der Heyden, Saïd Bendahhou   +3 more
wiley   +1 more source

A qualitative assessment of patient journeys to a lipodystrophy diagnosis

Rare
Background: Lipodystrophy syndromes are a group of very rare disorders characterized by a deficiency of adipose tissue, that can present with a broad range of symptoms.
T. Kenny, S. Laird, S. Dunn, K. Iqbal
doaj   +1 more source