Results 71 to 80 of about 22,509 (201)

Combination antiretroviral therapy -associated lipodystrophy : insights into pathogenesis and treatment [PDF]

, 2011
Introduction: Combination antiretroviral therapy (cART) has decreased morbidity and mortality of individuals infected with human immunodeficiency virus type 1 (HIV-1). Its use, however, is associated with adverse effects which increase the patients risk
Sevastianova, Ksenia
core  

Genotype-stratified treatment for monogenic insulin resistance: a systematic review

Communications Medicine, 2023
Background Monogenic insulin resistance (IR) includes lipodystrophy and disorders of insulin signalling. We sought to assess the effects of interventions in monogenic IR, stratified by genetic aetiology.
Robert K. Semple, Kashyap A. Patel, Sungyoung Auh, ADA/EASD PMDI, Rebecca J. Brown   +4 more
doaj   +1 more source

Complications of lipodystrophy syndromes

, 2021
Lipodystrophy syndromes are rare complex multisystem disorders caused by generalized or partial lack of adipose tissue. Adipose tissue dysfunction in lipodystrophy is associated with leptin deficiency.
Akinci, Gulcin, AKINCI, BARIŞ, ÇELİK, MERVE   +2 more
core   +1 more source

The Lupus Damage Index Revision Program: Results From the Item Generation and Reduction Phases

Arthritis Care &Research, Volume 78, Issue 10, Page 1449-1466, October 2026.
Objective A data‐driven and expert/patient consensus‐based project to develop a revised Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) is under way supported by SLICC, ACR, and the Lupus Foundation of America. Our objective is to report the item generation and reduction phase results
Burak Kundakci, Megan R. W. Barber, Ann E. Clarke, Sindhu R. Johnson, Anselm Mak, Hermine I. Brunner, Murat Inanc, Rosalind Ramsey‐Goldman, Guillermo Ruiz‐Irastorza, Ellen M. Ginzler, John G. Hanly, Alexandra Legge, Cynthia Aranow, Laurent Arnaud, Nathalie Costedoat‐Chalumeau, Dafna D. Gladman, Søren Jacobsen, Michelle Petri, Clovis A. Silva, Évelyne Vinet, Alexandre E. Voskuyl, SDI Revision Literature Review Groups, SDI Revision Delphi Panel, SDI Revision Item Reduction Committee, SDI Revision Clinical Domain Groups, Ian N. Bruce   +25 more
wiley   +1 more source

Congenital Generalized Lipoatrophy (Berardinelli-Seip Syndrome) Type 1: Description of Novel AGPAT2 Homozygous Variants Showing the Highly Heterogeneous Presentation of the Disease

Frontiers in Endocrinology, 2020
Berardinelli-Seip congenital lipoatrophy (BSCL) is characterized by near total fat atrophy, associated with the progressive development of metabolic complications. BSCL type 1 (BSCL1) is caused by mutations in AGPAT2, encoding 1-acylglycerol-3phosphate-O-
Giovanni Ceccarini, Silvia Magno, Caterina Pelosini, Caterina Pelosini, Federica Ferrari, Maria Rita Sessa, Gaia Scabia, Gaia Scabia, Margherita Maffei, Margherita Maffei, Isabelle Jéru, Isabelle Jéru, Olivier Lascols, Olivier Lascols, Corinne Vigouroux, Corinne Vigouroux, Corinne Vigouroux, Ferruccio Santini   +17 more
doaj   +1 more source

Hypertriglyceridemia: Causes, Consequences, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
Hypertriglyceridemia (HTG) arises from the interplay between genetic susceptibility and secondary or precipitating factors, leading to dysregulated triglyceride‐rich lipoprotein (TRL) metabolism. Increased TRL production and impaired clearance promote distinct risk phenotypes: accumulation of apolipoprotein B(apoB)‐containing TRL remnants contributes ...
Shanshan Qi, Weiwei Chen, Kunhao Chen, Song Yang, Sibo Wang, Tongtian Ni, Dan Xu, Enqiang Mao, Erzhen Chen, Ying Chen   +9 more
wiley   +1 more source

PLIN1 haploinsufficiency is not associated with lipodystrophy

, 2018
Context: Monogenic partial lipodystrophy is a genetically heterogenous disease where only variants with specific genetic mechanisms are causative. Three heterozygous protein extending frameshift variants in PLIN1 have been reported to cause a phenotype ...
SE Flanagan (21320006), K Colclough (11139270), N Davis (13452210), S Ellard (13734760), J Curran (13283199), AT Hattersley (7655273), TW Laver (21853583), KA Patel (21320144), DB Savage (7771739), J Dale (13300002), MN Weedon (7655270)   +10 more
core   +6 more sources

Impaired expression of mitochondrial and adipogenic genes in adipose tissue from a patient with acquired partial lipodystrophy (Barraquer-Simons syndrome): a case report

Journal of Medical Case Reports, 2008
Introduction Acquired partial lipodystrophy or Barraquer-Simons syndrome is a rare form of progressive lipodystrophy. The etiopathogenesis of adipose tissue atrophy in these patients is unknown.
Guallar Jordi P, Rojas-Garcia Ricardo, Garcia-Arumi Elena, Domingo Joan C, Gallardo Eduardo, Andreu Antoni L, Domingo Pere, Illa Isabel, Giralt Marta, Villarroya Francesc   +9 more
doaj   +1 more source

Continuous Intraperitoneal Insulin Infusion for People With Type 1 Diabetes: A Literature Review and International Position Statement

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 8801-8811, October 2026.
ABSTRACT Achieving glucose targets without hypoglycaemia is the treatment goal in type 1 diabetes. Structured education, intensified insulin injection regimens, continuous glucose monitoring, automated insulin delivery, and ongoing support from a multidisciplinary team all support people with type 1 diabetes to achieve this goal. Despite these advances,
Nick Oliver, Bernhard Gehr, Rayhan Lal, Peter R. van Dijk, Eric Renard   +4 more
wiley   +1 more source

Role of FAP48 in HIV-associated lipodystrophy

, 2012
The highly active antiretroviral therapy (HAART) can cause a metabolic syndrome consisting of lipodystropy/lipoatrophy, dyslipidemia, and type 2 diabetes mellitus with an increased cardiovascular risk.
Lucariello A., Sellitto C., DE LUCA, Antonio, Costanzo C., Perna A., BALDI, Alfonso, Esposito V., Manente L.   +7 more
core   +1 more source