Results 71 to 80 of about 22,237 (207)

Nanomedicine for the Treatment of Pediatric Type 2 Diabetes: Progress, Challenges, and Translational Perspectives

Advanced Therapeutics, Volume 9, Issue 9, September 2026.
Overview of pharmaceutical nanocarriers in diabetes, illustrating applications of nanotechnology including enhanced drug and targeted drug delivery and nanosensors for glucose monitoring and diagnosis. ABSTRACT Pediatric type 2 diabetes mellitus (T2DM) is rapidly emerging as a critical global health concern, driven largely by rising childhood obesity ...
Nnamdi Ikemefuna Okafor, Bukosi Baloyi, Yahya E. Choonara   +2 more
wiley   +1 more source

Monoallelic POLR3A Variants Cause Early‐Onset Peripheral Neuropathy

Annals of Neurology, Volume 100, Issue 3, Page 655-671, September 2026.
Objective Biallelic variants in genes encoding the RNA polymerase III complex (Pol III) cause a spectrum of neurological disorders primarily affecting the central nervous system. Monoallelic variants have been reported in the POLR3B subunit only, associated with neurodevelopmental disorder, epilepsy, and peripheral neuropathy.
Luiza L. P. Ramos, Jevin M. Parmar, Robin Wijngaard, Bianca R. Grosz, Tamas Lazar, Ligia Mateiu, Steve Vucic, Kishore R. Kumar, Dennis Yeow, Laura I. Rudaks, Lonneke de Boer, Annemarie de Vreugd, David A. Koolen, Thatjana Gardeitchik, Anita Cairns, Krishnan Iyengar, Fernando Kok, Fernanda Barbosa Figueiredo, Alzira Alves de Siqueira Carvalho, Luiz S. Mageste Barbosa, Rodrigo Rezende Arantes, Tyler Rehbein, Jordan E. Bontrager, Elizabeth P. Wood, Janet E. Sowden, Gavin Monahan, Meutia Kumaheri, Ivy Cuijt, Melina Ellis, Gonzalo Perez‐Siles, Elyshia McNamara, Ronald van Beek, Celine B. Meijers, Ivaylo Tournev, Stephan Zuchner, Shoshana J. Wodak, Clara D. M. van Karnebeek, Nigel Laing, Liana N. Semcesen, David A. Stroud, David N. Herrmann, Velina Guergueltcheva, Marina L. Kennerson, Machteld M. Oud, Gianina Ravenscroft, Ayse Candayan, Albena Jordanova   +46 more
wiley   +1 more source

Role of FAP48 in HIV-associated lipodystrophy

, 2012
The highly active antiretroviral therapy (HAART) can cause a metabolic syndrome consisting of lipodystropy/lipoatrophy, dyslipidemia, and type 2 diabetes mellitus with an increased cardiovascular risk.
Lucariello A., Sellitto C., DE LUCA, Antonio, Costanzo C., Perna A., BALDI, Alfonso, Esposito V., Manente L.   +7 more
core   +1 more source

A qualitative assessment of patient journeys to a lipodystrophy diagnosis

Rare
Background: Lipodystrophy syndromes are a group of very rare disorders characterized by a deficiency of adipose tissue, that can present with a broad range of symptoms.
T. Kenny, S. Laird, S. Dunn, K. Iqbal
doaj   +1 more source

Congenital Generalized Lipoatrophy (Berardinelli-Seip Syndrome) Type 1: Description of Novel AGPAT2 Homozygous Variants Showing the Highly Heterogeneous Presentation of the Disease

Frontiers in Endocrinology, 2020
Berardinelli-Seip congenital lipoatrophy (BSCL) is characterized by near total fat atrophy, associated with the progressive development of metabolic complications. BSCL type 1 (BSCL1) is caused by mutations in AGPAT2, encoding 1-acylglycerol-3phosphate-O-
Giovanni Ceccarini, Silvia Magno, Caterina Pelosini, Caterina Pelosini, Federica Ferrari, Maria Rita Sessa, Gaia Scabia, Gaia Scabia, Margherita Maffei, Margherita Maffei, Isabelle Jéru, Isabelle Jéru, Olivier Lascols, Olivier Lascols, Corinne Vigouroux, Corinne Vigouroux, Corinne Vigouroux, Ferruccio Santini   +17 more
doaj   +1 more source

Extended Use of the Omnipod 5 Automated Insulin Delivery System in Adults With Type 1 Diabetes: 12‐Month Extension of a Randomized Controlled Trial

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
In this 12‐month extension of a randomized controlled trial, adults in France with Type 1 diabetes using the Omnipod 5 Automated Insulin Delivery System sustained a 17.9% increase in time in range (4.3 h/day) and a 1.14% HbA1c reduction, with preserved quality of life and few adverse events. ABSTRACT Background The Omnipod 5 Automated Insulin Delivery (
Eric Renard, Ruth S. Weinstock, Alfred Penfornis, Jean‐Pierre Riveline, Charles Thivolet, Trang T. Ly, for the OP5‐003 Research Group, Eric Renard, Anne Farret, Orianne Villard, Manal Al Masri, Ruth S. Weinstock, Suzan Bzdick, Alfred Penfornis, Catherine Petit, Marcelle Siadoua, Jean‐Pierre Riveline, Jean‐François Gautier, Tiphaine Vidal‐Trecan, Jean‐Baptiste Julla, Charline Potier, Djamila Bellili, Charles Thivolet, Sylvie Villar Fimbel, Redhouane Hami, Kaisa Kivilaid, Trang T. Ly, Bonnie Dumais, Todd Vienneau, Lauren M. Huyett, Lindsey R. Conroy   +30 more
wiley   +1 more source

New and emerging agents in the management of lipodystrophy in HIV-infected patients

, 2010
Eric BonnetService des Maladies Infectieuses, Hôpital Purpan, Toulouse, FranceAbstract: Lipodystrophy remains a major long-term complication in human immunodeficiency virus-infected patients under antiretroviral (ARV) therapy.
Eric Bonnet
core   +1 more source

Possibilities of physiotherapy in lipodystrophy [PDF]

, 2018
Lipodystrophy is one of the most common and the most undesirable female dermatological conditions. Both slim and overweight people can struggle with it. It is possible to fight cellulite with various physiotherapeutic techniques and methods.
Anna Fabian-Danielewska, Katarzyna Korabiusz, Korabiusz, Katarzyna, Wawryków, Agata, Fabian Danielewska, Anna, Stecko, Monika, Andrzej Torbé, Fabian-Danielewska, Anna, Monika Stecko, Torbé, Andrzej, Agata Wawryków   +10 more
core   +1 more source

Fetal Pathogenesis of Scoliosis Suggested by Asymmetry of Gene Expression in Paravertebral Muscles

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT Background The dysfunction of paravertebral muscles may contribute to the development of idiopathic scoliosis. Several candidate genes have been linked to scoliosis, but the underlying mechanisms and cell types remain unclear. Methods We initially included 40 idiopathic scoliosis cases and 19 controls. Muscle biopsies were obtained bilaterally
Tian Cheng, Gamze Yazgeldi Gunaydin, Elisabet Einarsdottir, Sini Ezer, Juha Kere, Shintaro Katayama, Paul Gerdhem   +6 more
wiley   +1 more source

Body Fat Maldistribution Among Human Immunodeficiency Virus-Infected Patients Attending Care and Treatment Clinics in Dar es salaam Municipal Hospitals [PDF]

, 2012
Long term side effects of HAART such as body fat mal-distribution have not been reported in Tanzania, since care and treatment began in 2004. Likewise perceptions and attitude of HIV/AIDS patients on treatment on their body fat mal-distribution has not ...
Njelekela, M.A, Njelekela, Marina Alois
core