Results 151 to 160 of about 17,237 (190)
Some of the next articles are maybe not open access.
Lipofuscin in Amyotrophic Lateral Sclerosis
Archives of Neurology, 1984Lipofuscin has been reported to accumulate in abnormal amounts in motor neurons of patients with amyotrophic lateral sclerosis (ALS). Microdensitometry was used to quantitate such lipid masses in spinal motor neurons in normal subjects compared with spinal motor neurons in ALS cases.
G B, McHolm, M J, Aguilar, F H, Norris
openaire +2 more sources
Nutrition Reviews, 2009
Lipofuscin is the fluorescent mixture of compounds that accumulates increasingly with age in human tissues, including the pigment epithelium of the retina. A substantial component of lipofuscin has been identified in the retina as N-retinylidene-N-retinylethanolamine.
openaire +2 more sources
Lipofuscin is the fluorescent mixture of compounds that accumulates increasingly with age in human tissues, including the pigment epithelium of the retina. A substantial component of lipofuscin has been identified in the retina as N-retinylidene-N-retinylethanolamine.
openaire +2 more sources
The photoreactivity of ocular lipofuscin
Photochemical & Photobiological Sciences, 2004Lipofuscin or "age pigment" is a lipid-protein complex which accumulates in a variety of postmitotic, metabolically active cells throughout the body. These complexes, which are thought to result from the incomplete degradation of oxidised substrate, have the potential for photoreactivity.
Boulton, M +3 more
openaire +3 more sources
Hepatocellular Lipofuscin in Pre‐Eclampsia
Asia-Oceania Journal of Obstetrics and Gynaecology, 1989AbstractThirty liver specimens from 30 pre‐eclamptic women with and without liver dysfunction were examined for the amount of lipofuscin pigment deposited. The amount of hepatic lipofuscin correlated positively with plasma urate concentrations. This finding may indicate an involvement of oxygen‐free radicals and xanthine oxidase in the pathophysiology ...
H, Minakami +4 more
openaire +2 more sources
Potential reversibility of lipofuscin accumulation
Archives of Gerontology and Geriatrics, 2002It is well established that the lipofuscin content of many post-mitotic cell types increases progressively during normal senescence. This age-related accumulation of lipofuscin may occur either: (1) because lipofuscin, once formed, is never degraded or eliminated from cells; or (2) because, despite turnover of this pigment, the rate of lipofuscin ...
openaire +2 more sources
Compositional studies of human RPE lipofuscin
Journal of Mass Spectrometry, 2010AbstractAge‐related macular degeneration (AMD) is an ocular disease that causes visual loss and legal blindness in the elderly population. The etiology of AMD is complex and may include genetic predispositions, accumulation of lipofuscin and drusen, local inflammation and neovascularization.
L S, Murdaugh +6 more
openaire +2 more sources
LIPOFUSCIN ACCUMULATION AND AGEING OF FIBROBLASTS
Gerontology, 1995Lipofuscin accumulates in postmitotic cells. In human fibroblasts, accumulation of lipofuscin as measured by cellular autofluorescence is exponential at first, but stops at a certain level. At the same time, cell death starts to decrease cell numbers significantly.
T, von Zglinicki +3 more
openaire +2 more sources
Can Lipofuscin Accumulation Be Prevented?
Rejuvenation Research, 2008During normal autophagic degradation of mitochondria and iron-containing proteins in lysosomes, iron is released intralysosomally where it may react with hydrogen peroxide forming hydroxyl radicals (Fenton reaction). Depending on their rate of formation, these highly reactive radicals can cross-link intralysosomal material, leading to lipofuscin ...
openaire +2 more sources
1987
Vitamin A, vitamin E, and phospholipids containing polyunsaturated fatty acids play important roles in both the structure and function of the retina, especially with regard to the photoreceptor cells (Robison et al., 1982). Deficiencies in dietary vitamin A, in forms which can be utilized as retinol, lead to night blindness, loss of photoreceptor outer
W. Gerald Robison, Martin L. Katz
openaire +1 more source
Vitamin A, vitamin E, and phospholipids containing polyunsaturated fatty acids play important roles in both the structure and function of the retina, especially with regard to the photoreceptor cells (Robison et al., 1982). Deficiencies in dietary vitamin A, in forms which can be utilized as retinol, lead to night blindness, loss of photoreceptor outer
W. Gerald Robison, Martin L. Katz
openaire +1 more source
Tsitologiia, 1978
Brain tissues of rats, mice and humans taken during autopsy were incubated in the medium containing 3,3'-diaminobenzidine (DAB), permitting to recognize mitochondrial cytochromes. The product of DAB oxidation was located in mitochondria and lypofuscin granules of the studied objects. Besides, the reaction product was found in the rat's brain structures
openaire +1 more source
Brain tissues of rats, mice and humans taken during autopsy were incubated in the medium containing 3,3'-diaminobenzidine (DAB), permitting to recognize mitochondrial cytochromes. The product of DAB oxidation was located in mitochondria and lypofuscin granules of the studied objects. Besides, the reaction product was found in the rat's brain structures
openaire +1 more source