Results 121 to 130 of about 102,476 (312)

Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer [PDF]

, 2016
Prostate cancer (CaP) is the most common adult male cancer in the developed world. The paucity of biomarkers to predict prostate tumor biology makes it important to identify key pathways that confer poor prognosis and guide potential targeted therapy ...
Adams, David J., Ahmad, Imran, Edwards, Joanne, Galbraith, Laura, Hedley, Ann, Leung, Hing Y., Loveridge, Carolyn, Markert, Elke, Mui, Ernest, Patel, Rachana, Repiscak, Peter, Rust, Alistair G., Salji, Mark, Sansom, Owen J., Tan, Ee Hong, van der Weyden, Louise   +15 more
core   +1 more source

Lipogenesis in rabbit adipose tissue

Journal of Lipid Research, 1975
Previous reports that rabbit adipose tissue does not synthesize fatty acids at significant rates led us to study in detail the pathways of lipogenesis and glyceroneogenesis in this tissue. We found that rabbit adipose tissue has a low capacity for denovo fatty acid synthesis from glucose but a high capacity for synthesis from pyruvate and acetate.
openaire   +3 more sources

Lipogenesis in human adipose tissue

Journal of Lipid Research, 1968
The pathways and some critical enzymes involved in lipogenesis in adipose tissue from 82 patients have been studied. Of the glucose-(14)C metabolized to lipid by isolated adipose cells, approximately 0.6% was recovered in fatty acids and the rest in glyceride-glycerol. Palmitate-1-(14)C was readily incorporated into neutral lipid.
openaire   +3 more sources

Inactivation of mitochondrial MUL1 E3 ubiquitin ligase deregulates mitophagy and prevents diet-induced obesity in mice

Frontiers in Molecular Biosciences
Obesity is a growing epidemic affecting millions of people worldwide and a major risk factor for a multitude of chronic diseases and premature mortality.
Lucia Cilenti, Jacopo Di Gregorio, Rohit Mahar, Fei Liu, Camilla T. Ambivero, Muthu Periasamy, Matthew E. Merritt, Antonis S. Zervos   +7 more
doaj   +1 more source

MALIC ENZYME AND LIPOGENESIS [PDF]

Proceedings of the National Academy of Sciences, 1964
E M, WISE, E G, BALL
openaire   +2 more sources

Obesity dependent metabolic signatures associated with nonalcoholic fatty liver disease progression [PDF]

, 2012
Our understanding of the mechanisms by which nonalcoholic fatty liver disease (NAFLD) progresses from simple steatosis to steatohepatitis (NASH) is still very limited.
Alonso, C, Barr, J, Caballería, J, Domínguez-Díez, A, Martínez Arranz, Ibon, Moto, J.M., Muntané Relat, Jordi, Romero Gómez, Manuel   +7 more
core  

Probiotics‐derived postbiotics improve host metabolic syndrome by activating the adipocyte thermogenic signaling pathway in high‐fat diet‐fed mice

iMetaOmics, EarlyView.
This schematic illustrates how probiotics‐derived postbiotics (PLBK®1–5) combat high‐fat diet‐induced obesity. Postbiotics remodel gut microbiota, boosting beneficial metabolites. These metabolites activate adipocyte thermogenesis (Ucp1/AMPK pathway), resulting in reduced body weight, improved insulin sensitivity, and alleviated hepatic steatosis in ...
Ye Tian, Liujing Huang, Yifan Liu, Xudong Mai, Yanbo Cheng, Bingdong Liu, Yixin Chen, Liwei Xie   +7 more
wiley   +1 more source

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, EarlyView.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source

Correction to “Transcriptional Regulation of De Novo Lipogenesis by SIX1 in Liver Cancer Cells”

Advanced Science, EarlyView.
wiley   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source