Results 101 to 110 of about 16,244 (260)

Beyond Protein Synthesis: The Multifunctional Role of Functional Amino Acids in Modulating Meat Quality in Ruminants

Animal Research and One Health, EarlyView.
Multifunctional roles of functional amino acids in regulating meat quality in ruminants: Functional amino acids (FAAs) regulate ruminant meat quality through multiple interconnected mechanisms, including antioxidant protection, metabolic regulation, signal transduction, structural support, and gene expression modulation.
Zixin Liu, Tian Xia, Xiaokang Lv, Man Ren, Chuanshe Zhou, Zhiliang Tan   +5 more
wiley   +1 more source

Evidence against the peroxisome proliferator-activated receptor α (PPARα) as the mediator for polyunsaturated fatty acid suppression of hepatic L-pyruvate kinase gene transcription

Journal of Lipid Research, 2000
The glycolytic enzyme, L-pyruvate kinase (L-PK), plays an important role in hepatic glucose metabolism. Insulin and glucose induce L-PK gene expression, while glucagon and polyunsaturated fatty acids (PUFA) inhibit L-PK gene expression.
David A. Pan, Michelle K. Mater, Annette P. Thelen, Jeffrey M. Peters, Frank J. Gonzalez, Donald B. Jump   +5 more
doaj   +1 more source

In Vivo Lipogenesis in the Domestic Chicken

Experimental Biology and Medicine, 1968
SummaryThe ability of chicks to utilize glucose-U-14C and acetate-1-14C as substrates for lipid synthesis has been studied. Chicks readily incorporated glucose and acetate carbon into fatty acids and nonsaponifiable lipids of liver and adipose tissue. Glucose-U-14C was also utilized for glyceride-glycerol formation.
G A, Leveille, E K, O'Hea, K, Chakbabarty   +2 more
openaire   +2 more sources

SIRT2-mediated ACSS2 K271 deacetylation suppresses lipogenesis under nutrient stress [PDF]

De novo lipogenesis is associated with the development of human diseases such as cancer, diabetes, and obesity. At the core of lipogenesis lies acetyl coenzyme A (CoA), a metabolite that plays a crucial role in fatty acid synthesis.
Behram, Cameron D., Lin, Hening, Teng, Wendi, Karim, Rezwana   +3 more
core   +1 more source

Comparative efficacy of GLP‐1 RA, tirzepatide and SGLT‐2 inhibitors in metabolic liver disease: A network meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aim Metabolic liver disease, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis, is a major cause of chronic liver dysfunction worldwide, creating an urgent need for effective treatments. This systematic literature review (SLR) and network meta‐analysis (NMA) systematically reviews and compares the efficacy and safety ...
Andrej Belančić, Christina Antza, Anastasios Poutachidis, Smaro Palaska, Elvira Meni Maria Gkrinia, Andrea Katrin Faour, Yusuf Ziya Sener, Seher Sener, Rehena Sultana   +8 more
wiley   +1 more source

Mechanisms of nutritional and hormonal regulation of lipogenesis

, 2001
Fat build-up is determined by the balance between lipogenesis and lipolysis/fatty acid oxidation. In the past few years, our understanding of the nutritional, hormonal and particularly transcriptional regulation of lipogenesis has expanded greatly ...
Kersten, S.
core  

Short‐term clinical responses in horses and ponies treated with canagliflozin: A clinical field study

Equine Veterinary Journal, EarlyView.
Abstract Background Treatment with the sodium‐glucose co‐transporter 2 (SGLT2) inhibitor canagliflozin in insulin dysregulated (ID) horses has shown promising results in randomised clinical trials. Larger field studies are needed to further evaluate treatment responses and potential adverse effects under real‐world conditions.
Moa Hällbom, Sanna Truelsen Lindåse, Monika Wartel, Johan Bröjer   +3 more
wiley   +1 more source

Engineering Kluyveromyces marxianus as a Robust Synthetic Biology Platform Host

mBio, 2018
Throughout history, the yeast Saccharomyces cerevisiae has played a central role in human society due to its use in food production and more recently as a major industrial and model microorganism, because of the many genetic and genomic tools available ...
Paul Cernak, Raissa Estrela, Snigdha Poddar, Jeffrey M. Skerker, Ya-Fang Cheng, Annika K. Carlson, Berling Chen, Victoria M. Glynn, Monique Furlan, Owen W. Ryan, Marie K. Donnelly, Adam P. Arkin, John W. Taylor, Jamie H. D. Cate   +13 more
doaj   +1 more source

Nutrition and Metabolic Diseases: A Systematic Review of Functional Foods, Medicinal Plants, Phytochemicals, Bioactive Compounds and Nutrients Effective Against Metabolic Diseases

Food Chemistry International, EarlyView.
The study demonstrates how functional foods, medicinal plants, phytochemicals, bioactive compounds and essential nutrients combat metabolic diseases. It highlights their mechanisms, including antioxidant, anti‐inflammatory, insulin‐sensitising, lipid‐regulating, gut microbiota‐modulating and mitochondrial‐enhancing effects, leading to improved ...
Chinaza Godswill Awuchi, Sana Noreen, Sonia Morya   +2 more
wiley   +1 more source

Determination of Fatty Acid Oxidation and Lipogenesis in Mouse Primary Hepatocytes [PDF]

, 2017
Lipid metabolism in liver is complex. In addition to importing and exporting lipid via lipoproteins, hepatocytes can oxidize lipid via fatty acid oxidation, or alternatively, synthesize new lipid via de novo lipogenesis.
Cooper, Marcus P., Akie, Thomas E.
core   +1 more source