Results 81 to 90 of about 16,244 (260)

Hepatic Lipid Stress Drives Metabolic Dysfunction‐Associated Steatohepatitis Progression through FTO O‐GlcNAcylation‐Induced m6A Demethylation of HRAS

Advanced Science, EarlyView.
Lipid stress drives O‐GlcNAcylation of the m6A demethylase FTO at Ser195, enhancing its stability and demethylase activity. This modification removes m6A from HRAS mRNA, preventing its degradation and activating PI3K/AKT signaling to promote hepatic steatosis and inflammation.
Jia‐Xin Yin, Yan‐Lai Zhang, Qun Liu, Rui Liu, Hai‐Yang Yuan, Sui‐Dan Chen, Ming‐Hua Zheng, Kai Wang, Ni Tang, Ai‐Long Huang   +9 more
wiley   +1 more source

Lipogenesis in the sand rat (Psammomys obesus)

, 1983
Synthesis of fatty acids was measured in the liver and in epididymal adipose tissue of sand rats and albino rats. In chow-fed sand rats the rate of hepatic lipogenesis, as measured by the incorporation of 3H2O into fatty acids, was four- to sevenfold ...
E. Levy, J. H. Adler, B. Kalderon, A. Gutman   +3 more
core   +1 more source

The Characteristics of Tumor Microenvironment by the Single Cell Profile in Endometrial Cancer of no Specific Molecular Profile (NSMP) Subtype

Advanced Science, EarlyView.
A subset of tumor‐associated macrophages (TAMs) characterized by SPP1 expression is discovered, which may remodel the tumor microenvironment by potentially promoting CD4+ T cell stress and maintaining epithelial cell stemness through SPP1‐CD44, thereby potentially contributing to the proliferation and migration of tumor cells, which has been verified ...
Xinhui Yuan, Zhengyao Zhai, Chuyu Jing, Wei Zhang, Wenjuan Tian, Yulan Ren   +5 more
wiley   +1 more source

Effects of gastric inhibitory polypeptide, somatostatin and epidermal growth factor on lipogenesis in ovine adipose explants [PDF]

, 2000
Feeding raises the plasma concentrations of a number of gut-related hormones that may, in turn, influence the metabolism of peripheral tissues. This study investigated the effects of gut-related hormones on lipogenesis in explants from three differing ...
Baba, A.S.H., P.J. Buttery, Buttery, P.J., A.S.H. Baba, J.M.M. Harper, Harper, J.M.M.   +5 more
core   +3 more sources

Hepatocyte CBX2 Safeguards Hepatic Lipid Homeostasis by Elevating Ca2+‐CaMKK2‐AMPK Signaling to Counter MASLD

Advanced Science, EarlyView.
In hepatocytes, CBX2 promotes H3K4me3 enrichment at the Orai1 promoter to enhance Orai1 transcriptional activation, thereby increasing intracellular Ca2+ levels. The elevated Ca2+ activates the CaMKK2‐AMPK signaling cascade, resulting in ACC phosphorylation and downstream metabolic regulation. This cascade suppresses de novo lipogenesis (Fasn, Acc, Scd‐
Xiang Wei, Li Lin, Xiuyun Wang, Hui Du, Menglong Zhang, Kechao Tang, Han Gao, Xinrui Xie, Jingya Gao, Xu Wang, Zhenglin Wang, Siwei Huang, Lei Zhang, Fang Gu, Gong‐Hong Wei, Yinliang Qi, Wei Chen, Yongsheng Chang, Huabing Zhang   +18 more
wiley   +1 more source

The effect of spice principles on body composition and lipogenesis in rats [PDF]

, 2015
Inclusion of a spice like red pepper fruit and kokum powder in the diet led to a lowering of total lipids, particularly triglycerides in the liver. The total body fat was lowered in animals fed red pepper or capsaicin but not in animals fed kokum powder
Fayaz Pasha, P., Ramachandran, H.D.
core  

Transcriptional activation of lipogenesis by insulin requires phosphorylation of MED17 by CK2 [PDF]

, 2017
Phosphorylation of MED17 by distinct kinases enables nutrient-dependent transcriptional activation of lipogenesis by insulin.
Jose A. Viscarra, Viscarra, Jose A, Il-Hwa Hong, Hei Sook Sul, Hong, Il-Hwa, Yuhui Wang, Wang, Yuhui, Sul, Hei Sook   +7 more
core   +1 more source

DUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs

Advanced Science, EarlyView.
p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Yunpeng Lv, Feng Wu, Xiongjie Liang, Chong Liu, Wenhui Guo, Kejian Zhang, Jiawen Niu, Wenjie Jiang, Hongjian Xu, Anlong Jiang, Yang Zheng, Enming Yu, Xintao Wang, Jinglong Yan, Jingjun Xia, Chengchao Song   +15 more
wiley   +1 more source

Role of trans fatty acids in the nutritional regulation of mammary lipogenesis in ruminants

Animal, 2010
Fat is an important constituent contributing to the organoleptic, processing and physical properties of ruminant milk. Understanding the regulation of milk fat synthesis is central to the development of nutritional strategies to enhance the nutritional ...
K.J. Shingfield, L. Bernard, C. Leroux, Y. Chilliard   +3 more
doaj   +1 more source

Alcohol effects on hepatic lipid metabolism

Journal of Lipid Research, 2020
Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and progresses to alcoholic steatohepatitis, fibrosis, and cirrhosis.
Sookyoung Jeon, Rotonya Carr
doaj   +1 more source