Results 61 to 70 of about 16,244 (260)

[11C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice [PDF]

, 2016
PurposeAltered metabolism, including increased glycolysis and de novo lipogenesis, is one of the hallmarks of cancer. Radiolabeled nutrients, including glucose and acetate, are extensively used for the detection of various tumors, including ...
VanBrocklin, Henry F, Wang, Chunmei, Chen, Xin, Seo, Youngho, Puchowicz, Michelle, Calvisi, Diego F, Li, Xiaolei, Che, Li, Li, Lei, Blecha, Joseph E   +9 more
core   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Fads2 knockout mice reveal that ALA prevention of hepatic steatosis is dependent on delta-6 desaturase activity

Journal of Lipid Research
The production of the omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from alpha-linolenic acid (ALA) relies on the delta-6 desaturase (D6D) enzyme encoded by the Fads2 gene.
Blair MacLeod, Chenxuan Wang, Liam H. Brown, Emma Borkowski, Manabu T. Nakamura, Kyle RD. Wells, Keith R. Brunt, Ewa Harasim-Symbor, Adrian Chabowski, David M. Mutch   +9 more
doaj   +1 more source

Integrated Metabolomic and Transcriptomic Analysis Reveals Potential Gut-Liver Crosstalks in the Lipogenesis of Chicken

Animals, 2023
Growing evidence has shown the involvement of the gut–liver axis in lipogenesis and fat deposition. However, how the gut crosstalk with the liver and the potential role of gut–liver crosstalk in the lipogenesis of chicken remains largely unknown. In this
Can Chen, Weilin Chen, Hao Ding, Genxi Zhang, Kaizhou Xie, Tao Zhang   +5 more
doaj   +1 more source

Loss of regulation of lipogenesis in the Zucker diabetic (ZDF) rat

, 2000
We present here a study on the role of leptin in the regulation of lipogenesis by examining the effect of dietary macronutrient composition on lipogenesis in the leptin receptor-defective Zucker diabetic fatty rat (ZDF) and its lean litter mate (ZL ...
Laszlo G. Boros, W.-N. Paul Lee, Sara Bassilian, Shu Lim   +3 more
core   +1 more source

Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate [PDF]

, 2020
A genetic mouse model is used to reveal a two-pronged mechanism of fructose-induced de novo lipogenesis in the liver, in which fructose catabolism in hepatocytes provides a signal to promote lipogenesis, whereas fructose metabolism by the gut microbiota ...
Wellen, Kathryn E, Zhao, Steven, Katelyn D. Miller, Michael Gilbert, Steven Zhao, Izzo, Luke, Alessandro Carrer, Liu, Joyce, Cholsoon Jang, Kahealani Uehara, Zachary T. Schug, Gilbert, Michael, Fernandez, Sully, Rabinowitz, Joshua D, Gade, Terence P, Joshua D. Rabinowitz, Zeng, Xianfeng, Carrer, Alessandro, Joyce Liu, Snyder, Nathaniel W, Miller, Katelyn D, Trefely, Sophie, Jang, Cholsoon, Sophie Trefely, Kathryn E. Wellen, Paul M. Titchenell, Luke Izzo, Schug, Zachary T, Xianfeng Zeng, Nathaniel W. Snyder, Sully Fernandez, Terence P. Gade, Uehara, Kahealani, Titchenell, Paul M   +33 more
core   +1 more source

FBP1‐Mediated Compartmentalization of Glycolytic Enzyme Complexes Suppresses PKM2 Function to Ameliorate MASLD Progression

Advanced Science, EarlyView.
In normal hepatocytes, FBP1 forms compartmentalized complexes with PKM2, ENO1, and LDHA independent of its catalytic activity, inhibiting PKM2 activity and restricting excessive glycolysis. During MASLD progression, FBP1 downregulation markedly reduces the abundance of these complexes and releases the “hijacked” glycolytic enzymes, leading to PKM2 ...
Busong Wang, Yiping Tang, Na Li, Xuening Dai, Jing Wu, Bin Xue, Yuxin Chen, Jingzi Zhang, Lingdong Kong, Chaojun Li, Lei Fang   +10 more
wiley   +1 more source

Lack of adaptation in lipogenesis by hepatoma 9121

Journal of Lipid Research, 1968
The “minimal deviation” hepatoma 9121, implanted in rats, was shown to biosynthesize fatty acids from acetate-l-14C at the same rate as normal rat liver but faster than host liver.
J.C. Elwood, Harold P. Morris
doaj   +1 more source

Antibiotic-Induced Dysbiosis of Microbiota Promotes Chicken Lipogenesis by Altering Metabolomics in the Cecum

Metabolites, 2021
Elucidation of the mechanism of lipogenesis and fat deposition is essential for controlling excessive fat deposition in chicken. Studies have shown that gut microbiota plays an important role in regulating host lipogenesis and lipid metabolism.
Tao Zhang, Hao Ding, Lan Chen, Yueyue Lin, Yongshuang Gong, Zhiming Pan, Genxi Zhang, Kaizhou Xie, Guojun Dai, Jinyu Wang   +9 more
doaj   +1 more source

Hypoxia attenuates and HBS promotes adipocyte lipogenesis.

, 2013
A. Hypoxia inhibits adipocyte lipogenesis during differentiation: Lipogenesis measured by uptake of Adipo-Red reagent during visceral adipocyte differentiation in N, H conditions.
Garen Gaston (445971), Kevin A. Meyer (445970), Robert W. O’Rourke (445969), Ashley E. White (445972), Daniel L. Marks (124849), Carey N. Lumeng (385458)   +5 more
core   +1 more source