Results 51 to 60 of about 102,476 (312)

Lipogenesis in Rat Hepatocytes

Journal of Biological Chemistry, 1974
Abstract Hepatocytes, prepared by collagenase treatment of livers of ad libitum- and meal-fed rats, were incubated with glucose, fructose, lactate, and a number of other substrates, labeled uniformly with 14C and in the presence of 3HOH. The uptake of lactate and the incorporation of 14C into CO2 and glucose equals or exceeds rates reported in perfused
D G, Clark, R, Rognstad, J, Katz
openaire   +2 more sources

Resveratrol Anti-Obesity Effects: Rapid Inhibition of Adipocyte Glucose Utilization

Antioxidants, 2019
Studies in animal models of diabetes and obesity have shown that resveratrol mitigates complications of metabolic diseases, beyond those resulting from oxidative stress.
Christian Carpéné, Francisco Les, Guillermo Cásedas, Cécile Peiro, Jessica Fontaine, Alice Chaplin, Josep Mercader, Víctor López   +7 more
doaj   +1 more source

Prenatal hyperandrogenism induces alterations that affect liver lipid metabolism [PDF]

, 2016
Prenatal hyperandrogenism is hypothesized as one of the main factors contributing to26 the development of polycystic ovary syndrome (PCOS). PCOS patients have high risk27 of developing fatty liver and steatosis.
Abruzzese, Giselle Adriana, Ferreira, Silvana Rocío, Heber, María Florencia, Motta, Alicia Beatriz, Pignataro, Omar Pedro, Reynoso, Roxana María, Velez, Leandro Martin   +6 more
core   +2 more sources

Organismal Fructose Metabolism in Health and Non-Alcoholic Fatty Liver Disease

Biology, 2020
NAFLD has alarmingly increased, yet FDA-approved drugs are still lacking. An excessive intake of fructose, especially in liquid form, is a dietary risk factor of NAFLD. While fructose metabolism has been studied for decades, it is still controversial how
Shea Skenderian, Grace Park, Cholsoon Jang   +2 more
doaj   +1 more source

The metastasis inducer CCN1 (CYR61) activates the fatty acid synthase (FASN)-driven lipogenic phenotype in breast cancer cells [PDF]

, 2016
The angiogenic inducer CCN1 (Cysteine-rich 61, CYR61) is differentially activated in metastatic breast carcinomas. However, little is known about the precise mechanisms that underlie the pro-metastatic actions of CCN1. Here, we investigated the impact of
Espinoza, Ingrid, Lupu, Ruth, Menendez, Javier A., Vellón, Luciano   +3 more
core   +1 more source

Role of Protein Kinase CK2 in Aberrant Lipid Metabolism in Cancer

Pharmaceuticals, 2020
Uncontrolled proliferation is a feature defining cancer and it is linked to the ability of cancer cells to effectively adapt their metabolic needs in response to a harsh tumor environment.
Barbara Guerra, Olaf-Georg Issinger
doaj   +1 more source

Norcantharidin overcomes vemurafenib resistance in melanoma by inhibiting pentose phosphate pathway and lipogenesis via downregulating the mTOR pathway

Frontiers in Pharmacology, 2022
Melanoma is the most aggressive type of skin cancer with a high incidence and low survival rate. More than half of melanomas present the activating BRAF mutations, along which V600E mutant represents 70%–90%.
Lei Wang, Lei Wang, Lei Wang, Wuxiyar Otkur, Aman Wang, Wen Wang, Yitong Lyu, Lei Fang, Xiu Shan, Mingzhou Song, Mingzhou Song, Yan Feng, Yi Zhao, Hai-Long Piao, Huan Qi, Ji-Wei Liu   +15 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

NAT10 promotes liver lipogenesis in mouse through N4-acetylcytidine modification of Srebf1 and Scap mRNA

Lipids in Health and Disease
Background Metabolic dysfunction associated steatotic liver disease (MASLD), closely linked to excessive lipogenesis, induces chronic liver disease. MASLD often cause other metabolic diseases, such as cardiovascular disease, diabetes and obesity. However,
Zhouqi Wang, Xinxing Wan, Md Asaduzzaman Khan, Lin Peng, Xiaoying Sun, Xuan Yi, Ke Chen   +6 more
doaj   +1 more source

Effects of mitochondrial NADP+-dependent isocitrate dehydrogenase deficiency on fructose-induced obesity in mice [PDF]

, 2018
Obesity prevalence in the United States continues to increase and is associated with health consequences such as type 2 diabetes, hypertension, atherosclerosis, and hyperlipidemia.
Beane, Kaleigh Elizabeth, Montalbano, Allison Michelle   +1 more
core   +2 more sources