Results 51 to 60 of about 16,244 (260)

Role of inhibitory mechanisms in physiological regulation of lipogenesis

, 1962
The significance of inhibitory mechanisms in the regulation of hepatic lipogenesis was investigated by utilizing the "cold-fasted" state to evaluate their quantitative importance.
Edith Porter, Helen Korchak, E. J. Masoro   +2 more
core   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

Effects of Brassica oleracea extract on impaired glucose and lipid homeostasis in high-fat diet-induced obese mice

Asian Pacific Journal of Tropical Biomedicine, 2019
Objective: To examine the effect of Brassica oleracea extract (BO) on impaired glucose and lipid homeostasis in high-fat diet (HFD)-induced obese mice. Methods: Obesity of ICR mice was induced by feeding a HFD (45 kcal% lard fat) for 16 weeks. During the
Urarat Nanna, Jarinyaporn Naowaboot, Linda Chularojmontri, Pholawat Tingpej, Suvara Wattanapitayakul   +4 more
doaj   +1 more source

Hepatic gene expression of enzymes involved in lipogenesis.

, 2017
Hepatic gene expression of enzymes involved in lipogenesis.
Susanne Klaus (551409), Isabel Kanzleiter (3780001), Sara Schumann (3779995), Saskia Schreiber (3780004), Juliane Kasch (3779998)   +4 more
core   +1 more source

Single‐Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty‐Infiltrated Muscle

Advanced Science, EarlyView.
Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu, Renxian Wang, Dingding Wang, Quanzhong Ren, Ling Wang, Fangfang Duan, Guihe Yang, Ruixuan Yu, Yi Wang, Yingyu Zhang, Zetong Zang, Chuqi Li, Weijia Liu, Wenshuang Zhang, Yi Yuan, Zitong Cheng, Xiaoguang Cheng, Junbo Liang, Yajun Liu   +18 more
wiley   +1 more source

Lipogenesis in the genetically obese Zucker rat

, 1978
In situ fatty acid synthesis has been measured with 3H20 in lean and obese Zucker (fa/fa) rats. The accumulation of fatty acids was increased in both the liver and adipose tissue of young fa/fa rats as a result of both an increased rate of lipogenesis ...
Godbole, V.Y
core   +1 more source

Exposure to Nanoplastics During Pregnancy Induces Brown Adipose Tissue Whitening in Male Offspring

Toxics
Background: Polystyrene nanoplastics (PSNPs) have been recognized as emerging environmental pollutants with potential health impacts, particularly on metabolic disorders.
Zhaoping Shen, Kai Tian, Jiayi Tang, Lin Wang, Fangsicheng Zhang, Lingjuan Yang, Yufei Ge, Mengna Jiang, Xinyuan Zhao, Jinxian Yang, Guangdi Chen, Xiaoke Wang   +11 more
doaj   +1 more source

Arachidonic acid has a dominant effect to regulate lipogenic genes in 3T3-L1 adipocytes compared to omega-3 fatty acids

Food & Nutrition Research, 2015
Background: The effects of long-chain n-3 and n-6 polyunsaturated fatty acids (PUFA) on the regulation of adipocytes metabolism are well known. These fatty acids are generally consumed together in our diets; however, the metabolic regulation of ...
Hitesh Vaidya, Sukhinder Kaur Cheema
doaj   +1 more source

Unraveling the Role of Hepatic PGC1α in Breast Cancer Invasion: A New Target for Therapeutic Intervention?

Cells, 2023
Breast cancer (BC) is the most common cancer among women worldwide and the main cause of cancer deaths in women. Metabolic components are key risk factors for the development of non-alcoholic fatty liver disease (NAFLD), which may promote BC.
Kumar Ganesan, Cong Xu, Qingqing Liu, Yue Sui, Jianping Chen   +4 more
doaj   +1 more source

Effect of carbohydrate intake on de novo lipogenesis in human adipose tissue

, 1987
Rates of synthesis, from [14C]glucose, of fatty acids (de novo lipogenesis) and glycerol (triglyceride synthesis) were measured in biopsies of adipose tissue from nutritionally depleted patients given low- or high-carbohydrate intravenous nutrition ...
C. Chascione, J. Askanazi, D. H. Elwyn, J. M. Kinney, M. Davila, K. M. Gil   +5 more
core   +1 more source