Results 41 to 50 of about 16,244 (260)
Lipogenesis in Rat Hepatocytes
Journal of Biological Chemistry, 1974 Abstract Hepatocytes, prepared by collagenase treatment of livers of ad libitum- and meal-fed rats, were incubated with glucose, fructose, lactate, and a number of other substrates, labeled uniformly with 14C and in the presence of 3HOH. The uptake of lactate and the incorporation of 14C into CO2 and glucose equals or exceeds rates reported in perfused
D G, Clark, R, Rognstad, J, Katz
openaire +2 more sources
Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis
Advanced Science, EarlyView.Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang +9 more
wiley +1 more source
Role of Protein Kinase CK2 in Aberrant Lipid Metabolism in Cancer
Pharmaceuticals, 2020 Uncontrolled proliferation is a feature defining cancer and it is linked to the ability of cancer cells to effectively adapt their metabolic needs in response to a harsh tumor environment.
Barbara Guerra, Olaf-Georg Issinger
doaj +1 more source
Frontiers in Pharmacology, 2022 Melanoma is the most aggressive type of skin cancer with a high incidence and low survival rate. More than half of melanomas present the activating BRAF mutations, along which V600E mutant represents 70%–90%.
Lei Wang +15 more
doaj +1 more source
, 2021 In this study, we investigated the pharmacological effect of a water extract of Raphani Semen (RSWE) on alcoholic fatty liver disease (AFLD) using ethanol-induced AFLD mice (the NIAAA model) and palmitic acid (PA)-induced steatosis HepG2 cells.
Jae Jin Kim +7 more
core +1 more source
Dietary starch promotes hepatic lipogenesis in barramundi (Lates calcarifer) [PDF]
, 2020 Barramundi are a highly valued aquaculture species, and as obligate carnivores they have a demonstrated preference for dietary protein over lipid or starch to fuel energetic growth demands.
Skiba-Cassy, Sandrine +30 more
core +1 more source
Advanced Science, EarlyView.GSTM4 enhances the interaction between ACLY and the E3 ubiquitin ligase TRIM27, thereby increasing K48‐linked ubiquitination at the K554 site of ACLY and promoting its degradation. Consequently, GSTM4 regulates lipid synthesis, as well as the proliferation and metastasis of PCa cells, by modulating ACLY stability.
Kang‐Ping Xiong +11 more
wiley +1 more source
Lipogenesis in adipose tissue of rats fed different diets
, 1961 Lipogenesis and glucose uptake by epididymal fat pads of rats fed different diets have been investigated. Lipogenesis was found to be depressed in rats fed high fat, high fat and high protein, thyroid, thiouracil, and thiamine-deficient diets.
J. M. Khanade, M. C. Nath
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OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD
Advanced Science, EarlyView.This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li +11 more
wiley +1 more source
Foods, 2020 Silkworm, Bombyx mori, contains high amounts of beneficial nutrients, including amino acids, proteins, essential minerals, and omega-3 fatty acids. We have previously reported a technique for producing steamed and freeze-dried mature silkworm larval ...
Da-Young Lee +6 more
doaj +1 more source