Results 281 to 290 of about 75,579 (341)

Breast Cancer Brain Metastasis: Bridging Biological Mechanisms to Therapeutic Innovations

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Breast cancer brain metastasis (BCBrM) is driven by a multistep metastatic cascade and shaped by dynamic tumor–brain interactions. This review integrates current mechanistic insights, from molecular signaling pathways to immune evasion, and evaluates preclinical models and emerging therapies.
Jing Feng, Yuwei Tao, Fengkai Li, Suling Liu   +3 more
wiley   +1 more source

Effects of Dietary Crude Protein Level on Growth Performance, Carcass Traits, Meat Quality, and Fatty Acid Composition of Ningxiang Finishing Pigs. [PDF]

Animals (Basel)
Zeng X, Tang Y, Liu W, Wang Z, Huang P, Wang Q, Yang H.   +6 more
europepmc   +1 more source

Advancing Deuterium MRI to Track Human Cerebral Glucose Metabolism at 7 T: A Comparison of Glucose‐d2 and Glucose‐d7 Ingestion

NMR in Biomedicine, Volume 38, Issue 12, December 2025.
Deuterium metabolic imaging (DMI) enables non‐invasive assessment of glucose metabolism in the human brain. This study compared the use of glucose‐d7 ([1,2,3,4,5,6,6’‐2H7]glucose) and glucose‐d2 ([6,6’‐2H2]glucose) as an ingested tracer in 15 healthy participants at 7 T.
Daniel J. Cocking, Robin A. Damion, Elizabeth J. Simpson, Dorothee P. Auer, Richard Bowtell   +4 more
wiley   +1 more source

Harnessing engineered exosomes as METTL3 carriers: Enhancing osteogenesis and suppressing lipogenesis in bone marrow mesenchymal stem cells for postmenopausal osteoporosis treatment. [PDF]

Mater Today Bio
Li T, Zhao J, Yuan J, Ding R, Yang G, Cao J, Zhao X, Liu J, Liu Y, Xu P, Deng J, Miao X, Cheng X.   +12 more
europepmc   +1 more source

Rewriting the MASLD‐associated hepatocellular carcinoma script: Targeting epigenetics and metabolism

International Journal of Cancer, Volume 157, Issue 10, Page 1991-2003, 15 November 2025.
Abstract Abnormal epigenetic patterns are crucial for the progression of metabolic‐associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC) development. Recent research focused on the interplay between epigenetics and altered metabolic pathways in HCC from MASLD, suggesting that the reversibility of epigenetic changes offers ...
Chiara Aiello, Eric Felli, Teresa Musarra, Lorenzo Nevi, Annamaria Altomare, Jordi Gracia‐Sancho, Andrea Baiocchini, Simone Carotti   +7 more
wiley   +1 more source

Phenolic-Rich Indian Almond (<i>Terminalia catappa</i> Linn) Leaf Extract Ameliorates Lipid Metabolism and Inflammation in High-Fat Diet (HFD)-Induced Obese Mice. [PDF]

Metabolites
Deji-Oloruntoba OO, Kim JE, Song HJ, Seol A, Hwang DY, Jang M.   +5 more
europepmc   +1 more source

Metabolic Reprogramming in Lung Cancer: Hallmarks, Mechanisms, and Targeted Strategies to Overcome Immune Resistance

Cancer Medicine, Volume 14, Issue 21, November 2025.
ABSTRACT Background Lung cancer remains the leading cause of cancer‐related mortality worldwide. Although immunotherapy has revolutionized lung cancer treatment, its efficacy is often hindered by primary and acquired immune resistance. Increasing evidence indicates that metabolic reprogramming plays a crucial role in tumor progression and the ...
Yi Chen, Menglin Bai, Ming Liu, Zhenshan Zhang, Chenxue Jiang, Kejin Li, Yun Chen, Yaping Xu, Leilei Wu   +8 more
wiley   +1 more source

Single‐Cell Transcriptomic Analysis Identifies a Novel OLR1+ SLC7A7+ Liver‐Enriched Metastatic Subset With Immunometabolic Rewiring in Pancreatic Cancer

Cancer Medicine, Volume 14, Issue 21, November 2025.
ABSTRACT Background Pancreatic ductal adenocarcinoma (PDAC) is an exceptionally lethal malignancy, with high percents of patients presenting with liver metastases (LM). However, the mechanisms driving liver metastases remain critical bottlenecks requiring urgent exploration.
Xuan Yang, Xinyuan Chen, Zixin Wang, Yanfang Liu, Huiting Hu, Qingru Wu, Hailing Zhang, Yu Xiong, Xin Li, Xiaotao Cheng, Xiaoyu Ruan, Yan Gu   +11 more
wiley   +1 more source

Mesenchymal stem cells and their secretome modulate stress and enhance lipogenesis in bovine mammary epithelial cells. [PDF]

Stem Cell Res Ther
Tadmor-Levi R, Sharabi L, Koren A, Schlesinger S, Tzirkel-Hancock N, Argov-Argaman N.   +5 more
europepmc   +1 more source