Results 311 to 320 of about 75,579 (341)
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The IKKβ‐USP30‐ACLY Axis Controls Lipogenesis and Tumorigenesis
Hepatology, 2020Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death that develops as a consequence of obesity, cirrhosis, and chronic hepatitis. However, the pathways along which these changes occur remain incompletely understood.
Li Gu +8 more
semanticscholar +1 more source
Cell Biology International, 2020
As the first identified N6‐methyladenosine (m6A) demethylase, fat mass and obesity‐associated (FTO) protein is associated with fatty acid synthase (FASN) and lipid accumulation.
Donglei Sun +4 more
semanticscholar +1 more source
As the first identified N6‐methyladenosine (m6A) demethylase, fat mass and obesity‐associated (FTO) protein is associated with fatty acid synthase (FASN) and lipid accumulation.
Donglei Sun +4 more
semanticscholar +1 more source
Epidermal Lipogenesis in Ichthyosis
1978Several lines of evidence point to a connection between lipid metabolism and scaly skin. Inhibitors of cholesterol biosynthesis such as triparanol and nicotinic acid can produce scaly lesions superficially resembling ichthyosis1. A disturbance of cutaneous sterol ester biosynthesis accompanies the hyperkeratosis of essential fatty acid deficiency2, and
D. Mcgibbon, Mary F. Cooper, Sam Shuster
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Physiological and pathological roles of lipogenesis
Nature Metabolism, 2023Yong Geun Jeon +3 more
semanticscholar +1 more source
Effects of lysosomotropic agents on lipogenesis
Archives of Biochemistry and Biophysics, 1986Chloroquine, quinine, and NH4Cl are lysosomotropic agents which inhibit lysosomal function, apparently by raising the intralysosomal pH. We found that preincubation of cultured human skin fibroblasts with these lysosomotropic agents under serum-free conditions induced about a 10-fold stimulation of lipogenesis.
Karen L. Frayer +3 more
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Androgens, lipogenesis and prostate cancer
The Journal of Steroid Biochemistry and Molecular Biology, 2004Both experimental and epidemiological data indicate that androgens are among the main factors controlling the development, maintenance and progression of prostate cancer. Identifying the genes that are regulated by androgens represents a major step towards the elucidation of the mechanisms underlying the impact of androgens on prostate cancer cell ...
Ellen De Schrijver +6 more
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Molecular and Cellular Biochemistry, 1997
Intraperitoneal administration of [1,2-14C]-acetate to Wistar rats was used to assess tissue lipogenic rates after estimating the incorporation of the label into the tissular lipid fractions. Refeeding the animals with glucose (after an overnight fast) induced an increase in white adipose tissue (4.5 fold), liver (4.1 fold), small intestine (1.9 fold),
Francisco J. López-Soriano +3 more
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Intraperitoneal administration of [1,2-14C]-acetate to Wistar rats was used to assess tissue lipogenic rates after estimating the incorporation of the label into the tissular lipid fractions. Refeeding the animals with glucose (after an overnight fast) induced an increase in white adipose tissue (4.5 fold), liver (4.1 fold), small intestine (1.9 fold),
Francisco J. López-Soriano +3 more
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Chemical genetics in tumor lipogenesis
Biotechnology Advances, 2018Since cancer cells depend on de novo lipogenesis for energy supply, highly active membrane biosynthesis and signaling, enhanced fatty acid synthesis is a crucial characteristic of cancer cells. Hence, targeting lipogenic enzymes and signaling cascades is a very promising approach in developing innovative therapeutic agents for the fight against cancer.
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Regulation of Lipogenesis in Animal Tissues
1974Publisher Summary This chapter discusses the regulation of lipogenesis in animal tissues. Lipid is an essential component of all living cells, and a large group of lipids contain long-chain fatty acids in their molecules. Among fatty acid-containing lipids, glycerolipids are the most abundant; in them, fatty acids are esterified to glycerol.
Shosaku Numa, Satoshi Yamashita
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FEEDING FREQUENCY AND LIPOGENESIS IN UNDERNUTRITION
Canadian Journal of Physiology and Pharmacology, 1967Rats were fed either normal or subnormal amounts of a 60% carbohydrate (sucrose) diet for 12–14 days. Food was available to the control animals at all times and was presented to the undernourished rats either all at once, under which conditions it was eaten in 1–2 hours, or hourly in 24 small aliquots.
Clarence Cohn, Dorothy Joseph
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