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Lipoic acid biosynthesis defects
Journal of Inherited Metabolic Disease, 2014AbstractLipoate is a covalently bound cofactor essential for five redox reactions in humans: in four 2‐oxoacid dehydrogenases and the glycine cleavage system (GCS). Two enzymes are from the energy metabolism, α‐ketoglutarate dehydrogenase and pyruvate dehydrogenase; and three are from the amino acid metabolism, branched‐chain ketoacid dehydrogenase, 2 ...
Johannes A, Mayr +4 more
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Multifunctional Lipoic Acid Conjugates
Current Medicinal Chemistry, 2009Several hundreds of studies published the last decade have reported that alpha-lipoic acid (LA) possess the potential to intervene in various therapeutically interesting pathways. However, it should be noted that LA reportedly exerts most of its effects at high micromolar concentrations; that amides of LA exhibit higher biological activity than the ...
Koufaki, Maria, Detsi, A., Kiziridi, C.
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Lipoic acid: A multifunctional antioxidant
BioFactors, 2003Lipoic acid: a multifunctional ...
Bast, A., Haenen, G.R.M.M.
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Lipoic acid and lipoic acid analogs in cancer metabolism and chemotherapy
Expert Review of Clinical Pharmacology, 2014The lipoic acid (lipoate) coenzyme is unique in all of mammalian metabolism. It is not only crucial to the function of some of the major enzymes feeding carbon into the tricarboxylic acid cycle, but also generates dynamic regulatory information about the metabolic status of the mitochondrial matrix, ultimately functioning to control these metabolic ...
Paul M, Bingham +2 more
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2008
Discovery molecular structure A Trail of Research on Lipoic Acid, L.J. Reed Lipoic Acid Biosynthesis, N.M. Nesbitt, R.M. Cicchillo, K.H. Lee, T.L. Grove, and S.J. Booker The Search for Potent alpha-lipoic Acid Derivatives: Chemical and Pharmacological Aspects, M. Ben Yakir, Y. Katzhendler, and S.
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Discovery molecular structure A Trail of Research on Lipoic Acid, L.J. Reed Lipoic Acid Biosynthesis, N.M. Nesbitt, R.M. Cicchillo, K.H. Lee, T.L. Grove, and S.J. Booker The Search for Potent alpha-lipoic Acid Derivatives: Chemical and Pharmacological Aspects, M. Ben Yakir, Y. Katzhendler, and S.
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Mammalian lipoic acid activating enzyme
Archives of Biochemistry and Biophysics, 1967Abstract The presence of a lipoic acid activating enzyme has been demonstrated in animal liver and a 50-fold increase in the specific activity of the enzyme was achieved. Some of the general properties of the labile enzyme were determined on the partially purified preparations.
J N, Tsunoda, K T, Yasunobu
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Electrochemical Determination of Lipoic Acid
Journal of Analytical Chemistry, 2004Procedures for determining lipoic acid by voltammetry and coulometric titration with electrogenerated halogens using the biamperometric indication of the titration end-point were developed. Possible mechanisms of lipoic acid oxidation with electrogenerated halogens are discussed.
Ziyatdinova G. +2 more
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Alpha lipoic acid for dementia
Cochrane Database of Systematic Reviews, 2002Oxidative processes have been implicated in the pathogenesis of neurodegenerative dementias including Alzheimer's disease. Protecting the central nervous system against these damaging mechanisms may be a useful therapeutic approach. Alpha lipoic acid (ALA) is an endogenous antioxidant that interrupts cellular oxidative processes in both its oxidized ...
Anthony Klugman +3 more
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Arbor Clinical Nutrition Updates, 2006
In a nutshellALA is a powerful antioxidant, both water and lipid soluble, that can also regenerate other antioxidants.A range of ‘antioxidant’ and other clinical indications (such as chelating toxic metals) have been tested in small, open trials and/or animal studies.
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In a nutshellALA is a powerful antioxidant, both water and lipid soluble, that can also regenerate other antioxidants.A range of ‘antioxidant’ and other clinical indications (such as chelating toxic metals) have been tested in small, open trials and/or animal studies.
openaire +1 more source