Results 41 to 50 of about 46,973 (295)

Estabilização do ácido lipoico via encapsulação em nanocápsulas poliméricas planejadas para aplicação cutânea Stabilization of lipoic acid by encapsulation in polymeric nanocapsules designed for cutaneous administration

Química Nova, 2009
This work reports the development of polymeric nanocapsules containing lipoic acid prepared by interfacial deposition of poli(ε-caprolactona). The suspensions showed acid pH and encapsulation efficiencies from 77 to 90%.
Irene Clemes Külkamp, Karina Paese, Sílvia Stanisçuaski Guterres, Adriana Raffin Pohlmann   +3 more
doaj   +1 more source

Alpha‐Lipoic Acid Reduces NLRP3/ASC Expression and IL‐1β Release in Kupffer Cells and Improves Insulin Signaling in FL83B Hepatocytes Exposed to a Conditioned Medium [PDF]

Food Sci Nutr
Alpha‐lipoic acid (ALA) reduced NLRP3/ASC expression, attenuated upstream NF‐κB/ERK signaling, and decreased IL‐1β release while preserving mitochondrial membrane potential in murine Kupffer cells subjected to LPS priming and a second signal. Conditioned medium from ALA‐pretreated Kupffer cells (particularly 100 μM) enhanced glucose uptake and improved
Ko C, Lo Y, Nguyen T, Kao S, Wu C, Huang W, Shen S.   +6 more
europepmc   +2 more sources

Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. [PDF]

, 2019
Thermogenesis in brown adipose tissue (BAT) declines with age; however, what regulates this process remains poorly understood. Here, we identify mitochondria lipoylation as a previously unappreciated molecular hallmark of aged BAT in mice.
Chang, Chih-Hsiang, Chang, Hsin-Yi, Ikeda, Kenji, Ishihama, Yasushi, Jun, Heejin, Kajimura, Shingo, Oguri, Yasuo, Tajima, Kazuki, Wu, Jun, Yoneshiro, Takeshi   +9 more
core  

Single Solid‐State Ion Channels as Potentiometric Nanosensors

Advanced Functional Materials, EarlyView.
Single gold nanopores functionalized with mixed self‐assembled monolayers act as solid‐state ion channels for direct, selective potentiometric sensing of inorganic ions (Ag⁺). The design overcomes key miniaturization barriers of conventional ion‐selective electrodes by combining low resistivity with suppressed loss of active components, enabling robust
Gergely T. Solymosi, Gyula Jágerszki, Levente Illés, Péter Fürjes, Róbert E. Gyurcsányi   +4 more
wiley   +1 more source

BACE1 activity impairs neuronal glucose oxidation:rescue by beta-hydroxybutyrate and lipoic acid [PDF]

, 2015
Glucose hypometabolism and impaired mitochondrial function in neurons have been suggested to play early and perhaps causative roles in Alzheimer's disease (AD) pathogenesis. Activity of the aspartic acid protease, beta-site amyloid precursor protein (APP)
Arsenian, Bateman, Beal, Bielarczyk, Blass, Bogaert, Bosetti, Bouzier-Sore, Bubber, Butterworth, Casley, Casley, Caspersen, Coleman, Costantini, Danial, David L. Hamilton, DeKosky, DeKosky, Devi, Du, Fang, Forero, Fukumoto, Geula, Gibson, Giménez-Cassina, Guglielmotto, Gómez-Isla, Hager, Hamilton, Harada, Henderson, Henderson, Hirai, Holsinger, Huang, Hussain, Itoh, Jack, Jack, Jack, Jha, John A. Findlay, Johnson, Kankotia, Kawaja, Kim, Knopman, Ko, Korolainen, Lei, Li, Lustbader, Magistretti, Manczak, Martiskainen, Masdeu, Mastrogiacoma, Maurer, McKenna, Meakin, Michael L. J. Ashford, Mirshamsi, Mosconi, Mosconi, Mowrer, Mucke, Mullen, Nelson, Nilsen, Nunomura, O'Connor, Packer, Parker, Patel, Pereira, Perry, Phypers, Puglielli, Reger, Reiman, Sancheti, Shankar, Shearman, Sinha, Small, Sokoloff, Sorbi, Sowell, Swerdlow, Tyler, Vaishnavi, Vassar, Vassar, Velliquette, Vlassenko, von Kienlin, Wilkins, Wischmeyer, Wise, Xun, Yang, Yao, Yao, Zaidan, Zhang, Zhang, Zhao   +108 more
core   +6 more sources

Novel Functional Materials via 3D Printing by Vat Photopolymerization

Advanced Functional Materials, EarlyView.
This Perspective systematically analyzes strategies for incorporating functionalities into 3D‐printed materials via Vat Photopolymerization (VP). It explores the spectrum of achievable functionalities in recently reported novel materials—such as conductive, energy‐storing, biodegradable, stimuli‐responsive, self‐healing, shape‐memory, biomaterials, and
Sergey S. Nechausov, Patrick Fesser, Boris A. Bulgakov, Ulrich S. Schubert   +3 more
wiley   +1 more source

Efficiency of Alpha Lipoic Acid Therapy at Diabetic Foot Syndrome

Mìžnarodnij Endokrinologìčnij Žurnal, 2014
The article deals with increasing the effectiveness of treatment of patients with diabetes mellitus with diabetic foot syndrome (DFS) by applying the integrated treatment with α-lipoic acid.
I.V. Pankiv
doaj   +1 more source

Alpha-Lipoic Acid for the Prevention of Diabetic Macular Edema [PDF]

, 2011
Introduction: To evaluate the effect of alpha-lipoic acid (ALA) on the occurrence of diabetic macular edema. Methods: Randomized, double-blind, placebo-controlled, multicenter, multinational study. Patients were randomized to the treatment group with 600
Anselm Kampik, Christos Haritoglou, Hans P. Hammes, Joachim Gerss, Michael W. Ulbig, null null   +5 more
core   +1 more source

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

Advanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He, Haixia Zhu, Peipei Kang, Lili Feng, Chenghao Yu, Yanlin Zhu, Bin Liu, Zhengxiao Guo, Piaoping Yang   +8 more
wiley   +1 more source

Evidence of a metabolic memory to early-life dietary restriction in male C57BL/6 mice [PDF]

, 2012
<p>Background: Dietary restriction (DR) extends lifespan and induces beneficial metabolic effects in many animals. What is far less clear is whether animals retain a metabolic memory to previous DR exposure, that is, can early-life DR preserve ...
A Ceriello, A Dubey, A Nakamura, A Taguchi, BJ Merry, BJ Merry, BP Yu, BS Hass, C Hambly, C Messier, C Selman, C Selman, CK Lee, CK Lee, DP Argentino, EP Weiss, F Capstick, H Maeda, J Cantley, J Jacobson, JD Mulligan, JF Clinthorne, JM Dhahbi, JM Dhahbi, JR Mitchell, JR Speakman, L Fontana, LK Heilbronn, LM Redman, MJ Forster, MJ Forster, R Weindruch, R Weindruch, RJ Colman, RM Anson, S Goto, S Hempenstall, S Keipert, S Park, S Rezzi, SK Barnes, SL Johnston, SS Jessani, SX Cao, TM Wallace, W Mair, X Li   +46 more
core   +1 more source