Results 191 to 200 of about 89,481 (251)

Tankyrase‐2 regulates adipocyte differentiation through AMPK/mTOR signaling

The FEBS Journal, EarlyView.
Tankyrase 2 (TNKS2), a PARP family member, underpins adipocyte differentiation. TNKS2 controls LKB1 protein level, and consequently, the activity of the mTOR/AMPK system and adipocyte differentiation through a layered process. Pharmacological inhibition of TNKS2 leaves other PARPs and DNA repair active and therefore represents a novel target in ...
Boglarka Rauch, Gyula Ujlaki, Szilard Poliska, Nakayi Murahwa, Patrik Kovacs, Aladar Pettko‐Szandtner, Karen Uray, Peter Bai   +7 more
wiley   +1 more source

Defining Weight‐Loss‐Independent Hepatic Effects of Incretin‐Based Therapies

Diabetes, Obesity and Metabolism, EarlyView.
Mingyuan Zhang, Hanyang Liu, Yawen Hao, Lanlan Chen   +3 more
wiley   +1 more source

Plasma amylin levels in migraine and after erenumab treatment: A REFORM study

Headache: The Journal of Head and Face Pain, EarlyView.
Plain Language Summary Researchers are searching for blood tests that can show what is happening in migraine and help predict who will benefit from preventive treatment, and blood amylin (a signaling molecule known to trigger migraine) has been shown to be elevated in people with chronic migraine.
Rogelio Domínguez‐Moreno, Tyla I. Alexander, William K. Karlsson, Haidar M. Al‐Khazali, Michael L. Garelja, Rune H. Christensen, Messoud Ashina, Debbie L. Hay, Håkan Ashina   +8 more
wiley   +1 more source

ATP Release and Purinergic Signaling Potentiate β-Adrenergic Effects on Brown Adipocytes. [PDF]

Acta Physiol (Oxf)
Tozzi M, Berggreen EB, Zhang R, Gudiksen A, Li W, Matz MB, Pilegaard H, Hansen JB, Novak I.   +8 more
europepmc   +1 more source

Longitudinal effects of CGRP‐targeting migraine therapies on blood pressure and body mass index: A 12‐month retrospective analysis

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To compare blood pressure (BP) and body mass index (BMI) trajectories associated with individual calcitonin gene‐related peptide (CGRP)‐targeting migraine therapies versus matched CGRP‐unexposed controls. Background CGRP is a potent vasodilator with established roles in vascular homeostasis and metabolic regulation.
Phillip Phan, Scott Keith, Michael Li, Richard Hass, Wan‐Jen Hsieh, Michael Marmura, Hsiangkuo Yuan   +6 more
wiley   +1 more source

Pancreatic-liver crosstalk, novel molecular mediators, and 2025 therapeutic breakthroughs. [PDF]

World J Methodol
Pan HY, Chen WW, Liang JX, Sheng YY, Zhang WJ, Zhu XW, Wang SY, Yang GH, Liu Y, Xu TC.   +9 more
europepmc   +1 more source

Adrenal hormones in the maintenance of glucose homeostasis during prolonged fasting in male glucagon‐deficient mice [PDF]

J Diabetes Investig
Compensatory corticosterone‐mediated lipolysis and hepatic gluconeogenesis (via amino acids and glycerol) prevent hypoglycemia in GCGKO mice during prolonged fasting. ABSTRACT Aims/Introduction Glucagon is a key regulator of fasting glucose homeostasis, but the contribution of adrenal hormones during prolonged fasting remains unclear.
Kanie S, Nishida K, Seino Y, Hidaka S, Ueno S, Sumioki H, Tomatsu E, Haraguchi T, Murao N, Fujisawa H, Takayanagi T, Sugimura Y, Hayashi Y, Suzuki A.   +13 more
europepmc   +2 more sources

Role of glucagon in metabolic diseases

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Currently, diabetes is defined as “a chronic hyperglycemic state resulting from the absolute or relative insufficiency of insulin action,” emphasizing its characterization as an insulin‐related disease. However, glucagon dysregulation should also play a critical role in the pathophysiology of type 2 diabetes.
Tadahiro Kitamura, Yoko Tabei, Masaki Kobayashi   +2 more
wiley   +1 more source

Adipose tissue ceramides: emerging lipid components of extracellular vesicles and their influence on metabolic dysregulation. [PDF]

Front Endocrinol (Lausanne)
Angelini S, Sanz Molina JM, Castaldo F, Naumovski N, Passaro A, Sergi D.   +5 more
europepmc   +1 more source

Type 1 diabetes in the era of obesity: Pathophysiology and therapeutic implications

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Type 1 diabetes is defined by immune‐mediated beta‐cell failure and dependence on exogenous insulin. That definition is correct, but it may not fully describe many people seen in current clinical practice. Overweight and obesity are now common in type 1 diabetes, leading to variable combinations of high insulin requirement, hypertension ...
Zachary Bloomgarden
wiley   +1 more source