The Journal of Physiology, EarlyView.Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney +4 more
wiley +1 more source
Metabolic hubs in reproduction: The regulatory network of lipid droplets in gamete and embryo physiology (Review). [PDF]
Int J Mol MedPan L, Wen Z, Jin Y.
europepmc +1 more source
Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation
The Journal of Physiology, EarlyView.Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson +7 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Gestational Diabetes Mellitus (GDM) impacts on succinate metabolism and angiogenesis in the umbilical cord endothelium. (Left Panel) Succinate levels increase in both maternal and fetal circulation at delivery, with higher concentrations observed in GDM pregnancies compared to controls during late gestation.
Sergiy Klid +13 more
wiley +1 more source
Chronic Psychological Stress Activates TRP/TAM/CXCL1 Signaling to Promote Breast Cancer Adipocyte Lipolysis via KEAP1 m<sup>6</sup>A Demethylation. [PDF]
Research (Wash D C)Zhan D +8 more
europepmc +1 more source
Potential health benefits of cold‐water immersion: the central role of PGC‐1α
The Journal of Physiology, EarlyView.Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer +2 more
wiley +1 more source
The effect of daily aerobic cycling exercise on cannabis withdrawal: An inpatient randomised controlled trial. [PDF]
Sci RepMills L +10 more
europepmc +1 more source
Systemic Consequences of Chronic Ethanol Intake: From Microbiome Shifts to Metabolic Impairment
Comprehensive Physiology, Volume 16, Issue 2, April 2026.Chronic ethanol intake disrupts whole‐body homeostasis by reducing energy intake and body mass, impairing physical function, and reshaping the gut microbiome. Microbiota shifts and depletion of short‐chain fatty acids increase gut permeability and drive hepatic inflammation, dyslipidemia, and glucose intolerance.
Muni Swamy Ganjayi +9 more
wiley +1 more source
Looking behind the Solubilization Curtain: Microdialysis Provides Near-Real-Time Noncolloidal Drug Concentrations during In Vitro Lipolysis. [PDF]
Mol PharmTønning MH +4 more
europepmc +1 more source
Impaired Adipose Anabolism in Pancreatic Cancer Cachexia Is Reversed by HuR Inhibition
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.ABSTRACT Background Cachexia is defined by chronic loss of fat and muscle, is a frequent complication of pancreatic ductal adenocarcinoma (PDAC) and negatively impacts patient outcomes. Nutritional supplementation cannot fully reverse tissue wasting, and the mechanisms underlying this phenotype are unclear.
Paige C. Arneson‐Wissink +10 more
wiley +1 more source