Results 271 to 280 of about 123,419 (342)

Clinical features and outcomes of diabetic ketoacidosis in patients using SGLT2 inhibitors: A systematic review and meta‐analysis

open access: yesDiabetes, Obesity and Metabolism, Volume 27, Issue 10, Page 5805-5811, October 2025.
Abstract Aims Sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) are effective antihyperglycaemic agents; however, they also increase the risk of diabetic ketoacidosis (DKA). As the clinical evidence comparing DKA features between SGLT2i users and non‐users remains limited due to the low incidence of DKA, this study aimed to compare the clinical ...
Dahyeon Lee   +4 more
wiley   +1 more source

Decreases in circulating ANGPTL3/8 concentrations following retatrutide treatment parallel reductions in serum lipids

open access: yesDiabetes, Obesity and Metabolism, Volume 27, Issue 10, Page 5985-5995, October 2025.
Abstract Aims The aim of this study was to determine if retatrutide, a triple agonist of glucose‐dependent insulinotropic polypeptide (GIP) receptor, glucagon‐like peptide 1 (GLP‐1) receptor and glucagon (GCG) receptor, may lower serum triglyceride (TG) and low‐density lipoprotein cholesterol (LDL‐C) levels in part by decreasing circulating ...
Yi Wen   +12 more
wiley   +1 more source

Lipedema: Progress, Challenges, and the Road Ahead

open access: yesObesity Reviews, Volume 26, Issue 10, October 2025.
ABSTRACT Introduction Lipedema is a chronic and progressive disease that predominantly affects women, characterized by a disproportionate increase in subcutaneous adipose tissue (AT), particularly in the lower limbs. It is associated with significant physical disability, chronic pain, thromboembolism, and psychosocial distress.
Vincenza Cifarelli
wiley   +1 more source

Chronic Waterborne Exposure to Polystyrene Microplastics Induces Kupffer Cell Polarization Imbalance and Hepatic Lipid Accumulation

open access: yesThe FASEB Journal, Volume 39, Issue 17, 15 September 2025.
Chronic Polystyrene Microplastic (PS‐MP) Exposure Drives Hepatic Steatosis via Dual Inflammatory and Metabolic Pathways. Chronic PS‐MP exposure in C57BL/6N mice induces hepatic lipid deposition and elevated body fat through M1‐polarized Kupffer cells, IL‐17A/NF‐κB activation, and impaired lipid homeostasis.
Ting Li   +6 more
wiley   +1 more source

Depletion of WWP1 Increases Adrb3 Expression and Lipolysis in White Adipose Tissue of Obese Mice. [PDF]

open access: yesInt J Mol Sci
Nozaki Y   +6 more
europepmc   +1 more source

Gut Microbiota‐Derived Metabolites Orchestrate Metabolic Reprogramming in Diabetic Cardiomyopathy: Mechanisms and Therapeutic Frontiers

open access: yesThe FASEB Journal, Volume 39, Issue 17, 15 September 2025.
Schematic representation of how gut microbiota‐derived metabolites—such as SCFAs, TMAO, and tryptophan derivatives—modulate cardiac energy metabolism, inflammation, and epigenetic regulation, contributing to the pathogenesis of diabetic cardiomyopathy. Therapeutic strategies targeting the gut–heart axis hold translational promise for metabolic cardiac ...
Jing‐yu Jin   +12 more
wiley   +1 more source

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