Results 121 to 130 of about 24,646 (237)

Synthetic and Mechanistic Studies with Lipopeptide Antibiotics

, 2018
The cyclic lipopeptides comprise a number of clinically relevant classes of antibiotics that date back from the discovery of the polymyxins in 1947 to the recent introduction of the lipoglycopeptides.
Afd Chemical Biology and Drug Discovery, Kleijn, L.H.J., Chemical Biology and Drug Discovery   +2 more
core  

Supramolecular Complexes of Ultrashort Cationic Lipopeptides with Cyclodextrins: Improved Selectivity and Therapeutic Potential

Aggregate
In the last decade, the rise of antibiotic resistance has heightened interest in antimicrobial peptides and lipopeptides as promising alternatives to conventional antibiotics because of their lower propensity to develop resistance.
Chiara Bellini, Unai Atxabal, Szilvia Bősze, Orsolya Dobay, Andrea Horváth, Imola Cs. Szigyártó, Tamás Beke‐Somfai, Jesús Jiménez‐Barbero, István Puskás, Kata Horváti   +9 more
doaj   +1 more source

Potential Use of Microbial Surfactant in Microemulsion Drug Delivery System: A Systematic Review

Drug Design, Development and Therapy, 2020
Mandana Ohadi,1 Arash Shahravan,2 Negar Dehghannoudeh,3 Touba Eslaminejad,1 Ibrahim M Banat,4 Gholamreza Dehghannoudeh1,5 1Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran; 2Endodontology ...
Ohadi M, Shahravan A, Dehghannoudeh N, Eslaminejad T, Banat IM, Dehghannoudeh G   +5 more
doaj  

Development of potent pan‐coronavirus fusion inhibitors with a new design strategy

MedComm
Development of potent and broad‐spectrum drugs against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) remains one of the top priorities, especially in the cases of the emergence of mutant viruses and inability of current vaccines to prevent
Yuanmei Zhu, Zhongcai Gao, Xiaoli Feng, Lin Cheng, Nian Liu, Chao Liu, Shaowei Han, Qiaojiang Yang, Qingcui Zou, Huihui Chong, Zheng Zhang, Minghua Li, Gengshen Song, Yuxian He   +13 more
doaj   +1 more source

Lipopeptide release profile from biodegradable polymer.

, 2016
A representative release profile of C16-KGGK lipopeptide from P(SA:RA) and PLACO polymers evaluated at 1, 8, 24, 48, 72, 96 and 168 hrs. C16-KGGK release from PLACO peaked after about 72 hrs, whereas the release from P(SA:RA) was continuous throughout ...
Yechiel Shai (137126), Gilad Bachrach (116639), Lea H. Eckhard (639207), Yael Houri-Haddad (480479), Nurit Beyth (480476), Asaf Sol (116633), Rotem Zeharia (3109839), Shaul Beyth (3109842), Abraham J. Domb (639209)   +8 more
core   +1 more source

Recent advances in design and synthesis of self-adjuvanting lipopeptide vaccines

, 2008
Synthetic lipopeptide vaccines are being increasingly investigated mainly because of the advantages they offer over traditional vaccines, including safety of use in humans, high specificity in eliciting immune responses, greater purity and large scale ...
Fujita, Y., Pavla Simerska, Fujita, Yoshio, Simerska, P., Istvan Toth, Toth, Istvan, Yoshio Fujita, Toth, I., Simerska, Pavla   +8 more
core   +1 more source

Engineered Nanostructured Facial Lipopeptide as Highly Efficient Molecular Transporter

, 2015
Designing an effective peptide based molecular transporter for the intracellular delivery of hydrophilic therapeutic biomacromolecules remains a considerable challenge. Highly basic oligoarginine and lipidated arginine rich cell penetrating peptides have
Kasturee Chakraborty (1542859), Rituparna Sinha Roy (1542853), Chiranjit Dutta (1542856)   +2 more
core   +1 more source

Structure-activity relationship of lipopeptide Group A streptococcus (GAS) vaccine candidates on toll-like receptor 2

, 2010
To develop an oral nanovaccine delivery system for lipopeptide-based vaccine candidate against group A ...
Toth, I, Abdel-Aal, AM, Phillipps, KSM, S.M. Phillipps, Karen, Fujita, Yoshio, Good, M., Zaman, M, Zaman, Mehfuz, Fujita, Y, M. Abdel-Aal, Abu-Baker, Good, MF, Toth, Istvan   +11 more
core   +1 more source

Structural properties and binding stabilities of diverse lipopeptide fusion inhibitors^a.

, 2019
Structural properties and binding stabilities of diverse lipopeptide fusion inhibitorsa.
Ting Chen (15205), Jing Xue (170229), Qiang Wei (187077), Chuan Qin (235858), Zhe Cong (452962), Yuanmei Zhu (4497892), Huihui Chong (330720), Yuxian He (277042)   +7 more
core   +1 more source

Formation and characterization of lipopeptide layers at interfaces for the molecular recognition of antibodies

A lipopeptide, carrying the antigenic peptide segment 135-154 of VP1, one of the capsid proteins of the picornavirus which causes foot-and-mouth disease in cattle, was investigated in lipid monolayers on the water surface and on hydrophobic solid ...
Duschl, Claus, Boncheva, Mila, Vogel, Horst, Beck, Werner, Jung, Guenter   +4 more
core   +1 more source