Results 11 to 20 of about 24,712 (234)

Self-Adjuvanting Lipopeptide Vaccines [PDF]

Current Medicinal Chemistry, 2008
Despite the important role of adjuvants for vaccine development, relatively few adjuvants have been successfully incorporated into vaccines intended for human administration. This is in part due to the high toxicity associated with many experimental adjuvants. This lack of choice effectively hinders the ability to produce vaccines against many diseases,
Moyle, P.M., Toth, I.
openaire   +6 more sources

Influence of nutrient medium and time on lipopeptide synthesis in Bacillus subtilis GM5 [PDF]

BIO Web of Conferences
The level of expression of srfAD gene, a subunit AD of surfactin synthetase, and the yield of the total lipopeptide fraction were studied in relation to the composition of nutrient medium and the growth stage of the probiotic strain Bacillus subtilis ...
Lutfullina Guzel, Abubakirova Adela, Lutfullin Marat, Mardanova Ayslu   +3 more
doaj   +3 more sources

Synthesis of MUC1–lipopeptide chimeras [PDF]

Chemical Communications, 2010
An efficient method for the convergent assembly of MUC1-lipopeptide vaccine candidates is described. Chimeras consisting of MUC1 glycopeptides (bearing multiple copies of the T(N) and T tumour-associated carbohydrate antigens) tethered to the lipopeptide immunoadjuvant Pam(3)CysSer were synthesised in high yields using a fragment-based condensation ...
Brendan L, Wilkinson, Lara R, Malins, Candy K Y, Chun, Richard J, Payne   +3 more
openaire   +3 more sources

Production of Lipopeptide Biosurfactant by a Marine Nesterenkonia sp. and Its Application in Food Industry [PDF]

Frontiers in Microbiology, 2017
Biosurfactants are smart biomolecules which have wide spread application in medicines, processed foods, cosmetics as well as in bioremediation. In food industry, biosurfactants are used as emulsion stabilizing agents, antiadhesives, and antimicrobial ...
George S. Kiran, Sethu Priyadharsini, Arya Sajayan, Gopal B. Priyadharsini, Navya Poulose, Joseph Selvin   +5 more
doaj   +3 more sources

Molecular Mechanism of Lipopeptide Presentation by CD1a [PDF]

Immunity, 2005
CD1a is expressed on Langerhans cells (LCs) and dendritic cells (DCs), where it mediates T cell recognition of glycolipid and lipopeptide antigens that contain either one or two alkyl chains. We demonstrate here that CD1a-restricted T cells can discriminate the peptide component of didehydroxymycobactin lipopeptides.
Zajonc, Dirk M., Crispin, Max, Bowden, Thomas A., Young, David C., Cheng, Tan Yun, Hu, Jingdan, Costello, Catherine E., Rudd, Pauline M., Dwek, Raymond A., Miller, Marvin J., Brenner, Michael B., Moody, D. Branch, Wilson, Ian A.   +12 more
core   +7 more sources

Isolation, Identification, Screening and Fermentation Process Optimization of Bacillus Producing High Antimicrobial Lipopeptide [PDF]

Shipin gongye ke-ji
In order to screen out Bacillus sp. with high production of antimicrobial lipopeptide and determine its optimal fermentation conditions, the study isolated and identified antimicrobial lipopeptide-producing Bacillus sp. strains from traditional fermented
Shuaiqi JI, Rina WU, Taowei ZHANG, Mengxue LOU, Kairu HE, Yan ZHANG, Junrui WU   +6 more
doaj   +3 more sources

Lipopeptides for Vaccine Development [PDF]

Bioconjugate Chemistry, 2021
The development of lipopeptides (lipidated peptides) for vaccines is discussed, including their role as antigens and/or adjuvants. Distinct classes of lipopeptide architectures are covered including simple linear and ligated constructs and lipid core peptides.
openaire   +3 more sources

Nanostructure and Collagen-Stimulating Activity of Cationic Pentapeptide Lipopeptides. [PDF]

J Pept Sci
The self‐assembly in aqueous solutions, cytocompatibility and collagen production of lipopeptide C16–KTTKS (C16: hexadecyl) and a variant with arginine substitution for lysine, C16–RTTRS, are compared. ABSTRACT The self‐assembly in aqueous solutions, cytocompatibility, and collagen production of lipopeptide C16–KTTKS and a variant with arginine ...
de Mello LR, Castelletto V, Seitsonen J, Hamley IW.   +3 more
europepmc   +2 more sources

Lipopeptides in cosmetics [PDF]

International Journal of Cosmetic Science, 2010
SynopsisLipopeptides are biosurfactants extensively used in cosmetics. The consumption of cosmetics containing lipopeptides is increasing as a result of the exceptional surface properties and diverse biological activities of lipopeptides which facilitate a vast number of applications not only in the pharmaceutics industry which includes cosmetics but ...
M, Kanlayavattanakul, N, Lourith
openaire   +2 more sources

De novo design of lipopeptide-based fusion inhibitor as potential broad-spectrum antiviral agent [PDF]

, 2023
The recent surge in emerging viral infections warrants the need to design broad-spectrum antivirals. We aimed to develop a lead molecule that targets the membrane to block fusion, an obligate step of enveloped virus infection.
Amirul Islam, Mallick, Pradip Kumar, Tarafdar, Bibhas , Hazra, Mithila , Kamble, Avijit, Sardar, Nikesh , Dewangan, Sucharita , Bhowmick   +6 more
core   +1 more source