Results 221 to 230 of about 38,790 (251)

Lipopeptide preparation and analysis

2000
Lipophilic peptides and proteins present specific problems during preparation and analysis which require the use of modified methodology. This chapter discusses some of the methods that have been employed in the isolation and structural studies of the pulmonary surfactant-associated proteins B and C (SP-B and SP-C), other proteins with lipid-like ...
J, Johansson, M, Stark, M, Gustafsson, Y, Wang, S, Zaltash   +4 more
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Biocompatible Lipopeptide-Based Antibacterial Hydrogel

Biomacromolecules, 2019
A biocompatible hydrogel containing a hexapeptide as a key unit has been designed and fabricated. Our design construct comprises a β-sheet-rich short hexapeptide in the center with a hydrophobic long chain and hydrophilic triple lysine unit attached at the N- and C-terminals, respectively.
Anindyasundar Adak, Subhajit Ghosh, Varsha Gupta, Surajit Ghosh   +3 more
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Biosynthesis of isonitrile lipopeptides

Current Opinion in Chemical Biology
Isonitrile lipopeptides discovered from Actinobacteria have attracted wide attention due to their fascinating biosynthetic pathways and relevance to the virulence of many human pathogens including Mycobacterium tuberculosis. Specifically, the identification of the new class of isonitrile-forming enzymes that belong to non-heme iron (II) and α ...
Kaimin Jia, Helen Sun, Yiyan Zhou, Wenjun Zhang   +3 more
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Synthetic lipopeptides as novel adjuvants

Research in Immunology, 1992
Lipopeptides constitute potent novel immunoadjuvants in mice, rabbits and other species, enhancing markedly the immune response when given in mixture with antigens. Lipopeptides are non-toxic, non-pyrogenic and do not induce tissue damage when injected.
W G, Bessler, G, Jung
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Synthesis of MUC1–lipopeptide chimeras

Chemical Communications, 2010
An efficient method for the convergent assembly of MUC1-lipopeptide vaccine candidates is described. Chimeras consisting of MUC1 glycopeptides (bearing multiple copies of the T(N) and T tumour-associated carbohydrate antigens) tethered to the lipopeptide immunoadjuvant Pam(3)CysSer were synthesised in high yields using a fragment-based condensation ...
Brendan L, Wilkinson, Lara R, Malins, Candy K Y, Chun, Richard J, Payne   +3 more
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Cyclopeptamine lipopeptide antifungal agents

Expert Opinion on Therapeutic Patents, 1999
A solid phase mediated automated process was developed and used by researchers at Abbott laboratories to synthesise structurally diverse amino-lipopeptides as antifungal compounds. The cyclopeptamine analogues produced by this method possess an amino or substituted amino functionality in the proline ring (A) (Figure 2).
Debashis Ganguly, Michael J Rodriguez
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Synthesis of Lipopeptides by CLipPA Chemistry

2021
Lipidation of polypeptides with a fatty acid to form N-linked lipopeptides can be a time consuming process due to the need to mask other reactive function groups present on the side chains of amino acids. Cysteine Lipidation on a Peptide or Amino acid (CLipPA) technology enables the direct lipidation of unprotected peptides containing a free thiol ...
Victor, Yim, Yann O, Hermant, Paul W R, Harris, Margaret A, Brimble   +3 more
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Structure elucidation of bacterial nonribosomal lipopeptides

Organic & Biomolecular Chemistry, 2020
We provide a summary of the tools, which allow elucidate the structures of nonribosomal lipopetides.
Sebastian Götze, Pierre Stallforth
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Structure–Activity Relationships of Daptomycin Lipopeptides

Journal of Medicinal Chemistry, 2020
Daptomycin is a calcium-dependent cyclic lipodepsipeptide derived from the soil saprotroph Streptomyces roseosporus, and its antibiotic properties make it a key agent for treatment of drug-resistant Gram-positive infections. It is most commonly used clinically for the treatment of Gram-positive skin and skin structure infections (SSSI), Staphylococcus ...
John A. Karas, Glen P. Carter, Benjamin P. Howden, Adrianna M. Turner, Olivia K. A. Paulin, James D. Swarbrick, Mark. A. Baker, Jian Li, Tony Velkov   +8 more
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Novel dendrimeric lipopeptides with antifungal activity

Bioorganic & Medicinal Chemistry Letters, 2012
A series of new cationic lipopeptides containing branched, amphiphilic polar head derived from (Lys)Lys(Lys) dendron and C(8) or C(12) chain at C-end were designed, synthesized and characterized. Antimicrobial in vitro activity expressed as minimal inhibitory concentration (MIC) was evaluated against Gram-positive and Gram-negative bacteria and yeasts ...
Jolanta, Janiszewska, Marta, Sowińska, Aleksandra, Rajnisz, Jolanta, Solecka, Izabela, Łącka, Sławomir, Milewski, Zofia, Urbańczyk-Lipkowska   +6 more
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