Results 211 to 220 of about 23,990 (259)
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Self-Adjuvanting Lipopeptide Vaccines
Current Medicinal Chemistry, 2008Despite the important role of adjuvants for vaccine development, relatively few adjuvants have been successfully incorporated into vaccines intended for human administration. This is in part due to the high toxicity associated with many experimental adjuvants. This lack of choice effectively hinders the ability to produce vaccines against many diseases,
Moyle, P.M., Toth, I.
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Lipopeptide Pepducins as Therapeutic Agents
2021Pepducins are lipidated peptides that target the intracellular loops of G protein-coupled receptors (GPCRs) in order to modulate transmembrane signaling to internally located effectors. With a wide array of potential activities ranging from partial, biased, or full agonism to antagonism, pepducins represent a versatile class of compounds that can be ...
Emily, Michael +2 more
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International Journal of Pest Management, 2020
Plants are often subject to attack by fungi, nematodes and insects, which generate immense yield losses. Hence, the quest for crop protection solutions is ongoing, concurrent with greater awareness towards the use of synthetic chemicals in agricultural ...
K. Basaid +7 more
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Plants are often subject to attack by fungi, nematodes and insects, which generate immense yield losses. Hence, the quest for crop protection solutions is ongoing, concurrent with greater awareness towards the use of synthetic chemicals in agricultural ...
K. Basaid +7 more
semanticscholar +1 more source
Lipopeptide adjuvants in combination treatment
International Immunopharmacology, 2003Synthetic lipopeptides derived from the N-terminus of bacterial lipoprotein constitute potent immunoadjuvants for parenteral and mucosal immunization. When combined with tetanus toxoid (TT) or gliadin as antigens, the lipopeptide N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-(R)-cysteinyl-seryl-(lysyl)(3)-lysine (P(3)CSK(4)) markedly enhanced the ...
Bessler, Wolfgang G. +3 more
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ACS Infectious Diseases, 2021
Identifying the immunogenic moieties and their precise structure of carbohydrates plays an important role for developing effective carbohydrate-based subunit vaccines. This study assessed the structure-immunogenicity relationship of carbohydrate moieties
F. Khatun +7 more
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Identifying the immunogenic moieties and their precise structure of carbohydrates plays an important role for developing effective carbohydrate-based subunit vaccines. This study assessed the structure-immunogenicity relationship of carbohydrate moieties
F. Khatun +7 more
semanticscholar +1 more source
Lipopeptide preparation and analysis
2000Lipophilic peptides and proteins present specific problems during preparation and analysis which require the use of modified methodology. This chapter discusses some of the methods that have been employed in the isolation and structural studies of the pulmonary surfactant-associated proteins B and C (SP-B and SP-C), other proteins with lipid-like ...
J, Johansson +4 more
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Biocompatible Lipopeptide-Based Antibacterial Hydrogel
Biomacromolecules, 2019A biocompatible hydrogel containing a hexapeptide as a key unit has been designed and fabricated. Our design construct comprises a β-sheet-rich short hexapeptide in the center with a hydrophobic long chain and hydrophilic triple lysine unit attached at the N- and C-terminals, respectively.
Anindyasundar Adak +3 more
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Biosynthesis of isonitrile lipopeptides
Current Opinion in Chemical BiologyIsonitrile lipopeptides discovered from Actinobacteria have attracted wide attention due to their fascinating biosynthetic pathways and relevance to the virulence of many human pathogens including Mycobacterium tuberculosis. Specifically, the identification of the new class of isonitrile-forming enzymes that belong to non-heme iron (II) and α ...
Kaimin Jia +3 more
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Synthetic lipopeptides as novel adjuvants
Research in Immunology, 1992Lipopeptides constitute potent novel immunoadjuvants in mice, rabbits and other species, enhancing markedly the immune response when given in mixture with antigens. Lipopeptides are non-toxic, non-pyrogenic and do not induce tissue damage when injected.
W G, Bessler, G, Jung
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Synthesis of MUC1–lipopeptide chimeras
Chemical Communications, 2010An efficient method for the convergent assembly of MUC1-lipopeptide vaccine candidates is described. Chimeras consisting of MUC1 glycopeptides (bearing multiple copies of the T(N) and T tumour-associated carbohydrate antigens) tethered to the lipopeptide immunoadjuvant Pam(3)CysSer were synthesised in high yields using a fragment-based condensation ...
Brendan L, Wilkinson +3 more
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