Results 191 to 200 of about 15,558 (228)

Therapeutic Update on Glycopeptide and Lipopeptide Antibiotics

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1988
Glycopeptide antibiotics in the form of vancomycin have been available for almost 30 years. In the past, vancomycin usually was reserved as an alternative agent to treat staphylococcal and streptococcal infection in patients with a penicillin allergy or hemodialysis shunt infection. With the increasing frequency of both methicillin‐
J C, Rotschafer, M W, Garrison, K A, Rodvold   +2 more
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Synthetische Lipopeptide

2009
Lipoproteine mit der N-terminalen Struktur des Trispalmitoyl-Cysteins (Pam3Cys) finden sich in den Membranen einer Vielzahl von Bakterien. Strukturanaloge synthetische Lipopeptide sind zudem Gegenstand intensiver Forschungen bezüglich einer therapeutischen Anwendung als Adjuvantien.
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Novel dendrimeric lipopeptides with antifungal activity

Bioorganic & Medicinal Chemistry Letters, 2012
A series of new cationic lipopeptides containing branched, amphiphilic polar head derived from (Lys)Lys(Lys) dendron and C(8) or C(12) chain at C-end were designed, synthesized and characterized. Antimicrobial in vitro activity expressed as minimal inhibitory concentration (MIC) was evaluated against Gram-positive and Gram-negative bacteria and yeasts ...
Jolanta, Janiszewska, Marta, Sowińska, Aleksandra, Rajnisz, Jolanta, Solecka, Izabela, Łącka, Sławomir, Milewski, Zofia, Urbańczyk-Lipkowska   +6 more
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The Cyclic Lipopeptide Antibiotics

2017
The cyclic lipopeptides comprise a number of clinically relevant classes of antibiotics that date back from the discovery of the polymyxins in 1947 to the recent introduction of the semi-synthetic lipoglycopeptides. These natural products and natural product derivatives most often originate from soil-inhabiting and/or plant-derived producing organisms.
Laurens H. J. Kleijn, Nathaniel I. Martin   +1 more
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Biocompatible Lipopeptide-Based Antibacterial Hydrogel

Biomacromolecules, 2019
A biocompatible hydrogel containing a hexapeptide as a key unit has been designed and fabricated. Our design construct comprises a β-sheet-rich short hexapeptide in the center with a hydrophobic long chain and hydrophilic triple lysine unit attached at the N- and C-terminals, respectively.
Anindyasundar Adak, Subhajit Ghosh, Varsha Gupta, Surajit Ghosh   +3 more
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Biophysical studies of lipopeptide‐membrane interactions

Biopolymers, 1997
There are a number of naturally occurring motifs for lipidation of peptides and proteins. In cases in which this involves adding a single hydrocarbon chain to the peptide, it is either a fatty acid or an isoprenyl group. Lipopeptides will partition between membrane and aqueous phases.
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Glycopeptides, Lipopeptides, and Lipoglycopeptides

2011
Due to increasing resistance in Gram-positive organisms, use of glycopeptides, lipopeptides, and lipoglycopeptides will steadily increase. These three classes of drugs are primarily renally eliminated; therefore, CYP 450 interactions are not of concern.
Mary A. Ullman, John C. Rotschafer
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Other Lipopeptides

Science, 1995
Jon Y. Takemoto, Alessandro Ballio, Akira Isogai   +2 more
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Cyclic Lipopeptide Antibiotics

2008
Abstract Numerous natural products have been discovered, mainly from microorganisms, algae and plants, that often exhibit interesting and useful biological activities. Of these, cyclic lipopeptide antibiotics form the biggest group and provide several clinically important drugs.
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Lipopeptides development in cosmetics and pharmaceutical applications: A comprehensive review

Biotechnology Advances, 2023
Philipp Cavelius, Dania Awad, Thomas Bruck   +2 more
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