Novel Cyclic Lipopeptides Fusaricidin Analogs for Treating Wound Infections [PDF]
Frontiers in Microbiology, 2021 Both acute and chronic cutaneous wounds are often difficult to treat due to the high-risk for bacterial contamination. Once hospitalized, open wounds are at a high-risk for developing hospital-associated infections caused by multi drug-resistant bacteria
Joel Gil +13 more
doaj +7 more sources
Molecular Docking and Dynamics Simulation of Protein β-Tubulin and Antifungal Cyclic Lipopeptides [PDF]
Molecules, 2019 To elucidate interactions between the antifungal cyclic lipopeptides iturin A, fengycin, and surfactin produced by Bacillus bacteria and the microtubular protein β-tubulin in plant pathogenic fungi (Fusarium oxysporum, Colletrotrichum ...
Nubia Noemi Cob-Calan +6 more
doaj +4 more sources
Bacterial Aggregation Assay in the Presence of Cyclic Lipopeptides [PDF]
Bio-Protocol, 2018 Lipopeptides is an important class of biosurfactants having antimicrobial and anti-adhesive activity against pathogenic bacteria. These include surfactin, fengycin, iturin, bacillomycin, mycosubtilin, lichenysin, and pumilacidin (Arima et al., 1968 ...
Pengyuan Xiu +3 more
doaj +5 more sources
Application of HPCCC Combined with Polymeric Resins and HPLC for the Separation of Cyclic Lipopeptides Muscotoxins A–C and Their Antimicrobial Activity [PDF]
Molecules, 2018 Muscotoxins are cyanobacterial cyclic lipopeptides with potential applications in biomedicine and biotechnology. In this study, Desmonostoc muscorum CCALA125 strain extracts were enriched by polymeric resin treatment, and subjected to HPCCC affording ...
José Cheel +10 more
doaj +4 more sources
Integrated Omics Strategy Reveals Cyclic Lipopeptides Empedopeptins from Massilia sp. YMA4 and Their Biosynthetic Pathway [PDF]
Marine Drugs, 2021 Empedopeptins—eight amino acid cyclic lipopeptides—are calcium-dependent antibiotics that act against Gram-positive bacteria such as Staphylococcus aureus by inhibiting cell wall biosynthesis.
Shang-Tse Ho +7 more
doaj +2 more sources
Versatile role of Pseudomonas fuscovaginae cyclic lipopeptides in plant and microbial interactions [PDF]
Frontiers in Plant Science, 2022 Pseudomonas fuscovaginae is the most prominent bacterial sheath rot pathogen, causing sheath brown rot disease in rice. This disease occurs worldwide and it is characterized by typical necrotic lesions on the sheath, as well as a reduction in the number ...
Enrico Ferrarini +9 more
doaj +2 more sources
Genome mining for drug discovery: cyclic lipopeptides related to daptomycin. [PDF]
J Ind Microbiol Biotechnol, 2021 Abstract The cyclic lipopeptide antibiotics structurally related to daptomycin were first reported in the 1950s. Several have common lipopeptide initiation, elongation, and termination mechanisms. Initiation requires the use of a fatty acyl-AMP ligase (FAAL), a free-standing acyl carrier protein (ACP), and a specialized condensation ...
Baltz RH.
europepmc +4 more sources
Complex electrostatic effects on the selectivity of membrane-permeabilizing cyclic lipopeptides. [PDF]
Biophys J, 2023 Cyclic lipopeptides (CLiPs) have many biological functions, including the selective permeabilization of target membranes, and technical and medical applications. We studied the anionic CLiP viscosin from Pseudomonas along with a neutral analog, pseudodesmin A, and the cationic viscosin-E2K to better understand electrostatic effects on target ...
Steigenberger J +5 more
europepmc +5 more sources
Genomics-guided discovery and structure identification of cyclic lipopeptides from the Bacillus siamensis JFL15. [PDF]
PLoS ONE, 2018 In this research, a strain with broad-spectrum antimicrobial activities was isolated from the gastrointestinal tract of hairtail (Trichiurus haumela) and identified as Bacillus siamensis JFL15 through morphological, 16S rRNA, and average nucleotide ...
Ben-Hong Xu +6 more
doaj +2 more sources
Higher‐Level Structural Classification of Pseudomonas Cyclic Lipopeptides through Their Bioactive Conformation [PDF]
Advanced ScienceCyclic lipodepsipeptides (CLiPs) from Pseudomonas are membrane‐targeting specialized metabolites with diverse ecological roles and antimicrobial activities.
Benjámin Kovács +9 more
doaj +2 more sources