Results 31 to 40 of about 4,338 (170)

A Wagner–Meerwein‐Like Rearrangement Generates a Vinyl Group in the Biosynthesis of the Polychlorinated Lipopeptides Fischerazoles

Angewandte Chemie, EarlyView.
The fischerazoles, unusual cyanobacterial chlorinated lipopeptides are reported. During their biosynthesis, a linear fatty acyl‐acyl carrier protein (ACP) precursor is rearranged through the action of the S‐adenosyl‐methionine (SAM)‐dependent methyltransferase FshF, to generate a pendant vinyl group.
Sandra A. C. Figueiredo, Kathleen Abt, Konrad Viehrig, Peter J. Jervis, Teresa P. Martins, Iñaki Lacomba, Chuhan Li, Daniele Castagnolo, Pedro N. Leão   +8 more
wiley   +2 more sources

Iturinic Lipopeptide Diversity in the Bacillus subtilis Species Group – Important Antifungals for Plant Disease Biocontrol Applications

Frontiers in Microbiology, 2019
Iturins and closely related lipopeptides constitute a family of antifungal compounds known as iturinic lipopeptides that are produced by species in the Bacillus subtilis group.
Christopher A. Dunlap, Michael J. Bowman, Alejandro P. Rooney   +2 more
doaj   +1 more source

The Hydrophobicity and Antifungal Potentiation of Burkholdine Analogues

Molecules, 2022
The burkholdines are a family of cyclic lipopeptides reported to exhibit antifungal activity. We synthesized a series of 18 burkholdine analogues in good yield by conventional Fmoc-SPPS followed by cyclization with DIPCI/HOBt in the solution phase ...
Hiroyuki Konno, Mio Sasaki, Hinata Sano, Keima Osawa, Kazuto Nosaka, Shigekazu Yano   +5 more
doaj   +1 more source

Treatment of staphylococcal infections with cyclic lipopeptides [PDF]

Clinical Microbiology and Infection, 2008
Daptomycin is the first of a new class of antibiotics, the cyclic lipopeptides, for which a novel mechanism of action is hypothesised. Owing to its mode of action, daptomycin is rapidly bactericidal without being bacteriolytic, is active against static- and growing-phase bacteria, and has a low resistance rate in vitro.
openaire   +2 more sources

Atypical Condensation Domains Guide Discovery and Illuminate Biosynthesis of Myxoglucamides Featuring Vinyl‐Substituted, α‐Oxidized γ‐Amino Acids

Angewandte Chemie, EarlyView.
Genome mining of atypical condensation (C) domains leads to the discovery of myxoglucamides, glycolipopeptides featuring an unprecedented vinyl‐substituted, α‐oxidized γ‐amino acid. Biosynthetic studies reveal a discrete C‐domain‐like O‐acyltransferase, a β‐hydroxylation‐dependent chain‐extension checkpoint, and an unusual pathway for γ‐amino acid ...
Tingting Wang, Alexander Popoff, Maja Hunter, Guangzhi Dai, Ronald Garcia, Huixin Xu, Haowen Zhao, Asfandyar Sikandar, Liujie Huo, Rolf Müller, Chengzhang Fu   +10 more
wiley   +2 more sources

Formation and structural features of micelles formed by surfactin homologues

Frontiers in Bioengineering and Biotechnology, 2023
Surfactin, a group of cyclic lipopeptides produced by Bacillus subtilis, possesses surfactant properties and is a promising natural and biologically active compound.
Michał Bochynek, Michał Bochynek, Agnieszka Lewińska, Agnieszka Lewińska, Maciej Witwicki, Agnieszka Dębczak, Marcin Łukaszewicz, Marcin Łukaszewicz   +7 more
doaj   +1 more source

Daptomycin: A cyclic lipopeptide antimicrobial agent

Clinical Therapeutics, 2004
The aims of this article were: to summarize the pharmacology, pharmacokinetics, and efficacy of daptomycin; to explore its safety profile; and to discuss its current and potential roles as an antimicrobial therapy.A literature search was conducted using the MEDLINE (1966-August 2004) and International Pharmaceutical Abstracts (1970-August 2004 ...
Jeu, LilyAnn, Fung, Horatio B.
openaire   +2 more sources

Insights into the Defense-Related Events Occurring in Plant Cells Following Perception of Surfactin-Type Lipopeptide from Bacillus subtilis

Molecular Plant-Microbe Interactions, 2009
Multiple strains of Bacillus subtilis were demonstrated to stimulate plant defense responses, and cyclic lipopeptides may be involved in the elicitation of this induced systemic resistance phenomenon.
E. Jourdan, G. Henry, F. Duby, J. Dommes, J. P. Barthélemy, P. Thonart, M. Ongena   +6 more
doaj   +1 more source

Thiol-ene Enabled Chemical Synthesis of Truncated S-Lipidated Teixobactin Analogs

Frontiers in Chemistry, 2020
Herein is described the introduction of lipid moieties onto a simplified teixobactin pharmacophore using a modified Cysteine Lipidation on a Peptide or Amino acid (CLipPA) technique, whereby cysteine was substituted for 3-mercaptopropionic acid (3-MPA ...
Victor V. Yim, Victor V. Yim, Alan J. Cameron, Alan J. Cameron, Alan J. Cameron, Iman Kavianinia, Iman Kavianinia, Iman Kavianinia, Paul W. R. Harris, Paul W. R. Harris, Paul W. R. Harris, Margaret A. Brimble, Margaret A. Brimble, Margaret A. Brimble   +13 more
doaj   +1 more source

Inhibition of Lipopolysaccharide Activity by a Bacterial Cyclic Lipopeptide Surfactin [PDF]

The Journal of Antibiotics, 2006
Compounds that inactivate lipopolysaccharide (LPS) activity have the potential of being new anti-inflammatory agents. Therefore, we searched among microbial secondary metabolites for compounds that inhibited LPS-stimulated adhesion between human umbilical vein endothelial cells (HUVEC) and HL-60 cells.
Taichi, Takahashi, Osamu, Ohno, Yoko, Ikeda, Ryuichi, Sawa, Yoshiko, Homma, Masayuki, Igarashi, Kazuo, Umezawa   +6 more
openaire   +2 more sources