Results 181 to 190 of about 15,558 (228)

Self-Adjuvanting Lipopeptide Vaccines

Current Medicinal Chemistry, 2008
Despite the important role of adjuvants for vaccine development, relatively few adjuvants have been successfully incorporated into vaccines intended for human administration. This is in part due to the high toxicity associated with many experimental adjuvants. This lack of choice effectively hinders the ability to produce vaccines against many diseases,
Moyle, P.M., Toth, I.
openaire   +5 more sources

Lipopeptide preparation and analysis

2000
Lipophilic peptides and proteins present specific problems during preparation and analysis which require the use of modified methodology. This chapter discusses some of the methods that have been employed in the isolation and structural studies of the pulmonary surfactant-associated proteins B and C (SP-B and SP-C), other proteins with lipid-like ...
J, Johansson, M, Stark, M, Gustafsson, Y, Wang, S, Zaltash   +4 more
openaire   +2 more sources

Structure–Activity Relationships of Daptomycin Lipopeptides

Journal of Medicinal Chemistry, 2020
Daptomycin is a calcium-dependent cyclic lipodepsipeptide derived from the soil saprotroph Streptomyces roseosporus, and its antibiotic properties make it a key agent for treatment of drug-resistant Gram-positive infections. It is most commonly used clinically for the treatment of Gram-positive skin and skin structure infections (SSSI), Staphylococcus ...
John A. Karas, Glen P. Carter, Benjamin P. Howden, Adrianna M. Turner, Olivia K. A. Paulin, James D. Swarbrick, Mark. A. Baker, Jian Li, Tony Velkov   +8 more
openaire   +3 more sources

Biosynthesis of isonitrile lipopeptides

Current Opinion in Chemical Biology
Isonitrile lipopeptides discovered from Actinobacteria have attracted wide attention due to their fascinating biosynthetic pathways and relevance to the virulence of many human pathogens including Mycobacterium tuberculosis. Specifically, the identification of the new class of isonitrile-forming enzymes that belong to non-heme iron (II) and α ...
Kaimin Jia, Helen Sun, Yiyan Zhou, Wenjun Zhang   +3 more
openaire   +2 more sources

Synthetic lipopeptides as novel adjuvants

Research in Immunology, 1992
Lipopeptides constitute potent novel immunoadjuvants in mice, rabbits and other species, enhancing markedly the immune response when given in mixture with antigens. Lipopeptides are non-toxic, non-pyrogenic and do not induce tissue damage when injected.
W G, Bessler, G, Jung
openaire   +2 more sources

Synthesis of MUC1–lipopeptide chimeras

Chemical Communications, 2010
An efficient method for the convergent assembly of MUC1-lipopeptide vaccine candidates is described. Chimeras consisting of MUC1 glycopeptides (bearing multiple copies of the T(N) and T tumour-associated carbohydrate antigens) tethered to the lipopeptide immunoadjuvant Pam(3)CysSer were synthesised in high yields using a fragment-based condensation ...
Brendan L, Wilkinson, Lara R, Malins, Candy K Y, Chun, Richard J, Payne   +3 more
openaire   +2 more sources

Lipopeptide adjuvants in combination treatment

International Immunopharmacology, 2003
Synthetic lipopeptides derived from the N-terminus of bacterial lipoprotein constitute potent immunoadjuvants for parenteral and mucosal immunization. When combined with tetanus toxoid (TT) or gliadin as antigens, the lipopeptide N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-(R)-cysteinyl-seryl-(lysyl)(3)-lysine (P(3)CSK(4)) markedly enhanced the ...
Bessler, Wolfgang G., Mittenbühler, Klaus, Esche, Ulrich vor dem, Huber, Maria   +3 more
openaire   +3 more sources

Enrichment and Purification of Lipopeptide Biosurfactants

2010
A great many methods are available for the concentration of biosurfactants from microbiological media. The strongest known biosurfactant, surfactin, serves as a model in many studies, so is used here to illustrate the diversity in approaches to product enrichment.
Simon C, Baker, Chien-Yen, Chen
openaire   +2 more sources

Structure elucidation of bacterial nonribosomal lipopeptides

Organic & Biomolecular Chemistry, 2020
We provide a summary of the tools, which allow elucidate the structures of nonribosomal lipopetides.
Sebastian Götze, Pierre Stallforth
openaire   +2 more sources

Solid-Phase Synthesis of Octapeptin Lipopeptides

2019
Octapeptins are naturally derived cyclic lipopeptide antibiotics with activity against a range of Gram-negative pathogens, including highly resistant strains. Octapeptin C4, an exemplar of the class, was synthesized using a combination of Fmoc solid-phase peptide synthesis (SPPS) and solution-phase cyclization.
Hansford, Karl A., Ziora, Zyta M., Cooper, Matthew A., Blaskovich, Mark A. T.   +3 more
openaire   +5 more sources