Results 211 to 220 of about 50,842 (252)
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Lipophilicity of Aminopyridazinone Regioisomers
Journal of Agricultural and Food Chemistry, 2003Ten pairs of pyridazinone regioisomers were prepared, and their lipophilicity was described by the logarithm of the octanol/water partition coefficient (log P) determined experimentally and calculated with prediction methods. The 4- and 5-(substituted amino)-3(2H)-pyridazinone regioisomers were synthesized by nucleophilic substitution of one of the ...
Massud A S, Anwair +9 more
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Lipophilicity in drug discovery
Expert Opinion on Drug Discovery, 2010The role of lipophilicity in determining the overall quality of candidate drug molecules is of paramount importance. Recent developments suggest that, as well as determining pre-clinical ADMET (absorption, distribution, metabolism, elimination and toxicology) properties, compounds of optimal lipophilicity might have increased chances of success in ...
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Phenolic Acids Enzymatic Lipophilization
Journal of Agricultural and Food Chemistry, 2005Lipophilization is the esterification of a lipophilic moiety (fatty acid or fatty alcohol) on different substrates (phenolic acid, sugar, protein, ...), resulting in new molecules with modified hydrophilic/lipophilic balance. This reaction can be obtained chemically or enzymatically using different enzymes. Phenolic acids possess interesting biological
Figueroa-Espinoza, Maria-Cruz +1 more
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Lipases in lipophilization reactions
Biotechnology Advances, 2007Lipases are used in various sectors, as pharmaceutical, food or detergency industry. Their advantage versus classical chemical catalysts is that they exhibit a better selectivity and operate in milder reaction conditions. Theses enzymes can also be used in lipophilization reactions corresponding to the grafting of a lipophilic moiety to a hydrophilic ...
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Mechanism of Ocular Penetration of Lipophilic Drugs from Lipophilic Vehicles
Journal of Pharmaceutical SciencesSince eyedrops have conventionally been formulated in aqueous vehicles, ocular pharmacokinetic studies are generally performed using aqueous buffers to identify physicochemical properties of the drug and the vehicles that influence drug absorption. In recent years, biocompatible lipophilic vehicles are increasingly finding application in ocular drug ...
Carmen Liu +3 more
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Lipophilicity and drug activity
1979The understanding of drug potency in biological systems requires an understanding of chemical structures in terms of physical and chemical properties: transport and distribution of a drug in a biological multicompartment system, the affinity of the drug to a complementary — structurally unknown — receptor, and the interaction of the drug with its ...
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Lipophilicity and ADMET Analysis of Quinoline-1,4-quinone Hybrids
Pharmaceutics, 2023Ewa Bębenek +2 more
exaly
Transport of biological lipophiles: effect of lipophile structure
Journal of the American Chemical Society, 1983Henry J. Pownall +2 more
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