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Lipophilized Antioxidants [PDF]
, 2019 Lipophilized antioxidants are amphiphilic molecules constituted of a lipid moiety covalently linked to a polar group possessing antioxidant properties. They are multifunctional molecules possessing interesting physicochemical (antioxidant, surface active) and biological (antimicrobial, antiviral, antiinflammatory, anticarcinogenic, etc.) properties ...
Figueroa-Espinoza, Maria Cruz +4 more
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Lipophilicity of the Nitrophenols
The Journal of Organic Chemistry, 2000The lipophilicity of the nitrophenols, expressed as a water-solvent partition coefficient, P, has been investigated using the solvation equation, log P = c + eE + sS + aA + bB + vV. It is shown that this equation accounts quantitatively for lipophilicity in a selection of water-solvent systems, viz: octanol, 1,2-dichloroethane, and cyclohexane.
, Abraham, , Du, , Platts
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Lipophilicity Determination of Highly Lipophilic Compounds by Liquid Chromatography
Chemistry & Biodiversity, 2009AbstractDifferent experimental strategies using short columns in both conventional liquid chromatography (HPLC) and ultra‐high pressure liquid chromatography (UHPLC) were evaluated to allow, for the first time with these techniques, the lipophilicity determination of compounds with log P>5.
Guillot, Amandine +6 more
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Amino Acids, 1994
The lipophilicity (or hydrophobicity) of amino acids is an important property relevant for protein folding and therefore of great interest in protein engineering. For peptides or peptidomimetics of potential therapeutic interest, lipophilicity is related to absorption and distribution, and thus indirectly relates to their bioactivity. A rationalization
H van de Waterbeemd, N El Tayar
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The lipophilicity (or hydrophobicity) of amino acids is an important property relevant for protein folding and therefore of great interest in protein engineering. For peptides or peptidomimetics of potential therapeutic interest, lipophilicity is related to absorption and distribution, and thus indirectly relates to their bioactivity. A rationalization
H van de Waterbeemd, N El Tayar
exaly +4 more sources
Lipophilicity in Molecular Modeling
Pharmaceutical Research, 1996The molecular lipophilicity potential (MLP) offers a three-dimensional representation of lipophilicity, a molecular property encoding intermolecular recognition and intramolecular interactions.The interest and applications of the MLP in molecular modeling are varied, as illustrated here.The MLP is a major tool to assess the dependence of lipophilicity ...
Testa, Bernard +4 more
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Lipophilic Microconstituents of Milk
2007Milk has long been recognized as a source of macro- and micronutrients, immunological components, and biologically active substances, which not only allow growth but also promote health in mammalian newborns. Many milk lipids, lipid-soluble substances, and their digested products are bioactive, including vitamins and vitamin-like substances. Vitamins A,
A. Baldi, L. Pinotti
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Lipophilicity and Solvation of Anionic Drugs
Chemistry - A European Journal, 2002This paper first gives a brief review of the main techniques used to measure the lipophilicity of neutral and ionic drugs, namely the shake-flask method, potentiometry, and cyclic voltammetry at liquid-liquid interfaces. The lipophilicity of 28 acidic compounds with various functional groups was studied by potentiometry and cyclic voltammetry in the n ...
Hubert Girault +2 more
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