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Mechanism of Ocular Penetration of Lipophilic Drugs from Lipophilic Vehicles

Journal of Pharmaceutical Sciences
Since eyedrops have conventionally been formulated in aqueous vehicles, ocular pharmacokinetic studies are generally performed using aqueous buffers to identify physicochemical properties of the drug and the vehicles that influence drug absorption. In recent years, biocompatible lipophilic vehicles are increasingly finding application in ocular drug ...
Carmen Liu +3 more
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Lipophilicity

2008
Li Di, Edward H. Kerns
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Lipophilicity and drug activity

1979
The understanding of drug potency in biological systems requires an understanding of chemical structures in terms of physical and chemical properties: transport and distribution of a drug in a biological multicompartment system, the affinity of the drug to a complementary — structurally unknown — receptor, and the interaction of the drug with its ...
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