Results 281 to 290 of about 130,911 (332)
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Journal of Organic Chemistry, 2018
A practical synthesis of 2,4-methanopyrrolidines was elaborated. The key synthetic step was an intramolecular photochemical [2 + 2]-cycloaddition of an acrylic acid derivative in flow.
Vadym V. Levterov +6 more
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A practical synthesis of 2,4-methanopyrrolidines was elaborated. The key synthetic step was an intramolecular photochemical [2 + 2]-cycloaddition of an acrylic acid derivative in flow.
Vadym V. Levterov +6 more
semanticscholar +1 more source
Lipophilicity of Aminopyridazinone Regioisomers
Journal of Agricultural and Food Chemistry, 2003Ten pairs of pyridazinone regioisomers were prepared, and their lipophilicity was described by the logarithm of the octanol/water partition coefficient (log P) determined experimentally and calculated with prediction methods. The 4- and 5-(substituted amino)-3(2H)-pyridazinone regioisomers were synthesized by nucleophilic substitution of one of the ...
Massud A S, Anwair +9 more
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Effects of intramolecular hydrogen bonds on lipophilicity
European Journal of Pharmaceutical Sciences, 2019Intramolecular hydrogen bonds (IMHBs) affect the lipophilicity and physicochemical properties of small organic molecules and drug candidates. Considering IMHBs in drug design is an important strategy for improving the lipophilicity and physicochemical ...
Deliang Chen +6 more
semanticscholar +1 more source
Lipophilicity in drug discovery
Expert Opinion on Drug Discovery, 2010The role of lipophilicity in determining the overall quality of candidate drug molecules is of paramount importance. Recent developments suggest that, as well as determining pre-clinical ADMET (absorption, distribution, metabolism, elimination and toxicology) properties, compounds of optimal lipophilicity might have increased chances of success in ...
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GLYCOSYLTRANSFERASES OF LIPOPHILIC SMALL MOLECULES
Annual Review of Plant Biology, 2006Glycosyltransferases of small molecules transfer sugars to a wide range of acceptors, from hormones and secondary metabolites to biotic and abiotic chemicals and toxins in the environment. The enzymes are encoded by large multigene families and can be identified by a signature motif in their primary sequence, which classifies them as a subset of ...
Bowles, Dianna J +3 more
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Phenolic Acids Enzymatic Lipophilization
Journal of Agricultural and Food Chemistry, 2005Lipophilization is the esterification of a lipophilic moiety (fatty acid or fatty alcohol) on different substrates (phenolic acid, sugar, protein, ...), resulting in new molecules with modified hydrophilic/lipophilic balance. This reaction can be obtained chemically or enzymatically using different enzymes. Phenolic acids possess interesting biological
Figueroa-Espinoza, Maria-Cruz +1 more
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Drug Development and Industrial Pharmacy, 2016
The aim of the present paper was to investigate the promoting activity of borneol on the transdermal permeation of drugs with differing lipophilicity, and probe its alterations in molecular organization of stratum corneum (SC) lipids.
Q. Yi +4 more
semanticscholar +1 more source
The aim of the present paper was to investigate the promoting activity of borneol on the transdermal permeation of drugs with differing lipophilicity, and probe its alterations in molecular organization of stratum corneum (SC) lipids.
Q. Yi +4 more
semanticscholar +1 more source
Lipases in lipophilization reactions
Biotechnology Advances, 2007Lipases are used in various sectors, as pharmaceutical, food or detergency industry. Their advantage versus classical chemical catalysts is that they exhibit a better selectivity and operate in milder reaction conditions. Theses enzymes can also be used in lipophilization reactions corresponding to the grafting of a lipophilic moiety to a hydrophilic ...
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Mechanism of Ocular Penetration of Lipophilic Drugs from Lipophilic Vehicles
Journal of Pharmaceutical SciencesSince eyedrops have conventionally been formulated in aqueous vehicles, ocular pharmacokinetic studies are generally performed using aqueous buffers to identify physicochemical properties of the drug and the vehicles that influence drug absorption. In recent years, biocompatible lipophilic vehicles are increasingly finding application in ocular drug ...
Carmen Liu +3 more
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Lipophilicity and drug activity
1979The understanding of drug potency in biological systems requires an understanding of chemical structures in terms of physical and chemical properties: transport and distribution of a drug in a biological multicompartment system, the affinity of the drug to a complementary — structurally unknown — receptor, and the interaction of the drug with its ...
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