Results 261 to 270 of about 130,911 (332)

Recent Developments in Ferulic Acid- and Caffeic Acid-Based Hybrids with Potential Anticancer Properties. [PDF]

Molecules
Peter S, Sibali LL, Khwaza V, Paca AM.
europepmc   +1 more source

Palladium(II) Complexes with Chloro-Substituted Salicyl Schiff Bases: Exploring Multimodal Anticancer Mechanisms and Catalase Inhibition. [PDF]

Molecules
Dragojević JS, Milanović Ž, Milisavljević K, Milutinović M, Herenda S, Hasković E, Vanis N, Divac VM, Kostić MD.   +8 more
europepmc   +1 more source

Interspecies scaling of suprachoroidal drug delivery using ocular geometry and drug physicochemical properties. [PDF]

Sci Rep
Patil MA, Matter BA, Santana C, Kompella UB.   +3 more
europepmc   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs. [PDF]

Adv Healthc Mater
Lindner S, Keim S, Haddadzadegan S, Fernandez Romero O, Zöller K, Stern G, Cesi I, Kafedjiiski K, Bernkop-Schnürch A.   +8 more
europepmc   +1 more source

Hit-Identification to Novel Antileishmanial Agents from a β‑Pinene Scaffold: from Synthesis to <i>In Vitro</i> Evaluation and <i>In Silico</i> SAR/ADMET Profiling. [PDF]

ACS Omega
Martins GDS, M da S Santos B, Emiliano YSS, Santos JPA, Machado GM, de Carvalho MS, Sette KM, Rodrigues IA, T de Souza AM, Torres-Santos EC, G Finelli F, Leal ICR.   +11 more
europepmc   +1 more source

Lipophilic antioxidants

, 2015
openaire   +1 more source

Lipophilized Antioxidants [PDF]

, 2019
Lipophilized antioxidants are amphiphilic molecules constituted of a lipid moiety covalently linked to a polar group possessing antioxidant properties. They are multifunctional molecules possessing interesting physicochemical (antioxidant, surface active) and biological (antimicrobial, antiviral, antiinflammatory, anticarcinogenic, etc.) properties ...
Figueroa-Espinoza, Maria Cruz, Bourlieu, Claire, Durand, Erwann, Lecomte, Jérôme, Villeneuve, Pierre   +4 more
openaire   +2 more sources

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Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization.

Journal of Medicinal Chemistry, 2020
Lipophilicity has a dominant effect on many parameters that determine unbound drug exposure as well as drug potency. Despite this, analysis of a large body of drug data indicates lipophilicity has no consistent directional impact on dose.
Randy R Miller, Maria Madeira, H. Wood, W. Geissler, C. Raab, Iain J Martin   +5 more
semanticscholar   +1 more source

Lipophilicity Determination of Highly Lipophilic Compounds by Liquid Chromatography

Chemistry & Biodiversity, 2009
AbstractDifferent experimental strategies using short columns in both conventional liquid chromatography (HPLC) and ultra‐high pressure liquid chromatography (UHPLC) were evaluated to allow, for the first time with these techniques, the lipophilicity determination of compounds with log P>5.
Guillot, Amandine, Henchoz, Yveline, Moccand, Cyril, Guillarme, Davy, Veuthey, Jean-Luc, Carrupt, Pierre-Alain, Martel, Sophie   +6 more
openaire   +2 more sources

Lipophilicity of amino acids

Amino Acids, 1994
The lipophilicity (or hydrophobicity) of amino acids is an important property relevant for protein folding and therefore of great interest in protein engineering. For peptides or peptidomimetics of potential therapeutic interest, lipophilicity is related to absorption and distribution, and thus indirectly relates to their bioactivity. A rationalization
Nabil El Tayar
exaly   +4 more sources