Results 271 to 280 of about 130,911 (332)

The impact of lipophilicity on environmental processes, drug delivery and bioavailability of food components

Microchemical journal (Print), 2019
Lipophilic properties of the compound allow to predict its fate in living organisms and to propose the models of chemicals transport and accumulation in the ecosystem.
Tomasz Chmiel, A. Mieszkowska, Dagmara Kempińska-Kupczyk, Á. Kot-Wasik, J. Namieśnik, Z. Mazerska   +5 more
semanticscholar   +1 more source

Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility.

Journal of Medicinal Chemistry, 2018
As drug discovery moves increasingly toward previously "undruggable" targets such as protein-protein interactions, lead compounds are becoming larger and more lipophilic.
Matthew R. Naylor, Andrew M Ly, Mason J Handford, D. P. Ramos, C. Pye, A. Furukawa, Victoria G Klein, Ryan P. Noland, Quinn Edmondson, Alexandra C. Turmon, W. M. Hewitt, Joshua A. Schwochert, Chad E. Townsend, Colin N. Kelly, M. Blanco, R. Lokey   +15 more
semanticscholar   +1 more source

Lipophilic Microconstituents of Milk

2007
Milk has long been recognized as a source of macro- and micronutrients, immunological components, and biologically active substances, which not only allow growth but also promote health in mammalian newborns. Many milk lipids, lipid-soluble substances, and their digested products are bioactive, including vitamins and vitamin-like substances. Vitamins A,
A. Baldi, L. Pinotti
openaire   +2 more sources

Lipophilicity and Solvation of Anionic Drugs

Chemistry - A European Journal, 2002
This paper first gives a brief review of the main techniques used to measure the lipophilicity of neutral and ionic drugs, namely the shake-flask method, potentiometry, and cyclic voltammetry at liquid-liquid interfaces. The lipophilicity of 28 acidic compounds with various functional groups was studied by potentiometry and cyclic voltammetry in the n ...
Geraldine Bouchard, Pierre-Alain Carrupt, Bernard Testa   +2 more
exaly   +5 more sources

State of the art and prospects of methods for determination of lipophilicity of chemical compounds

Trends in Analytical Chemistry (TrAC), 2019
Lipophilicity of the compounds is useful to (i) explain their distribution in biological systems, which is different in plant and in animal organisms, (ii) predict the possible pathways of pollutant transport in the environment, and (iii) support drug ...
Dagmara Kempińska, Tomasz Chmiel, Á. Kot-Wasik, A. Mroz, Z. Mazerska, J. Namieśnik   +5 more
semanticscholar   +1 more source

Chalcone derivatives targeting mitosis: synthesis, evaluation of antitumor activity and lipophilicity.

European journal of medicinal chemistry, 2019
This study describes the synthesis of a series of chalcones, including pyrazole and α,β-epoxide derivatives, and evaluation of their cell growth inhibitory activity in three human tumor cell lines, as well as their lipophilicity using liposomes as a ...
P. Pinto, C. Machado, J. Moreira, José P. A. Almeida, Patrícia M. A. Silva, Ana C. Henriques, José X. Soares, J. Salvador, C. Afonso, M. Pinto, H. Bousbaa, H. Cidade   +11 more
semanticscholar   +1 more source

Chemical modulation of siRNA lipophilicity for efficient delivery.

Journal of Controlled Release, 2019
siRNA holds tremendous promise to knockdown the disease-promoting gene in any cell type that it can be delivered. The biggest challenge facing the clinical translation of siRNA is to overcome the barriers that impede the in vivo delivery.
Wanyi Tai
semanticscholar   +1 more source

Bioavailability of microplastic-bound pollutants in vitro: The role of adsorbate lipophilicity and surfactants.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2019
The potential role of microplastic particles (MPs) as vectors for lipophilic organic pollutants enhancing their uptake by organisms has repeatedly been discussed in the scientific community.
Patrick Heinrich, T. Braunbeck
semanticscholar   +1 more source

An application of QSRR approach and multiple linear regression method for lipophilicity assessment of flavonoids

Journal of Pharmaceutical and Biomedical Analysis, 2019
Graphical abstract Figure. No Caption available. HighlightsQSRR approach for lipophilicity assessment of structurally diverse flavonoids.Chromatographic column selection suitable for lipophilicity assessment of flavonoids.Evaluation of relationships ...
Mariusz Zapadka, Mateusz Kaczmarek, B. Kupcewicz, Przemysław Dekowski, Agata Walkowiak, A. Kokotkiewicz, M. Łuczkiewicz, A. Buciński   +7 more
semanticscholar   +1 more source

Lowering Lipophilicity by Adding Carbon: One-Carbon Bridges of Morpholines and Piperazines.

Journal of Medicinal Chemistry, 2018
In this article, we report our investigation of a phenomenon by which bridging morpholines across the ring with one-carbon tethers leads to a counterintuitive reduction in lipophilicity.
S. Degorce, M. Bodnarchuk, I. Cumming, James S. Scott   +3 more
semanticscholar   +1 more source