Results 1 to 10 of about 256,444 (143)

Lipopolysaccharide Endotoxins [PDF]

Annual Review of Biochemistry, 2002
▪ Abstract  Bacterial lipopolysaccharides (LPS) typically consist of a hydrophobic domain known as lipid A (or endotoxin), a nonrepeating “core” oligosaccharide, and a distal polysaccharide (or O-antigen). Recent genomic data have facilitated study of LPS assembly in diverse Gram-negative bacteria, many of which are human or plant pathogens, and have ...
Christian R H, Raetz, Chris, Whitfield
openaire   +2 more sources

Nonmuscle Myosin Heavy Chain ⅡA-Mediated Exosome Release via Regulation of the Rho-Associated Kinase 1/Myosin Light Chains/Actin Pathway

Frontiers in Pharmacology, 2020
Nonmuscle myosin ⅡA, a kind of ATP-dependent molecular motor, binds actin to form the molecular motors of the cell. We found that interfering with nonmuscle myosin heavy chain (NMMHC) ⅡA could affect the exosome release from microglial cells stimulated ...
Yanni Lv, Jin Chen, Jinfang Hu, Yisong Qian, Ying Kong, Longsheng Fu   +5 more
doaj   +1 more source

LPS inhibits arginase-1 expression in macrophages by up-regulating activity of cytochrome P450 1A1 epoxidase

陆军军医大学学报, 2023
Objective To explore the regulative effect and mechanism of cytochrome P450 1A1 (CYP1A1) on regulating lipopolysaccharide (LPS)-induced arginase-1 (Arg-1) expression in macrophages. Methods After mouse macrophage-like cell line RAW264.7 (RAW) was treated
TIAN Lixing, ZHU Junyu, WAN Linghui, LIANG Huaping   +3 more
doaj   +1 more source

Effects of Dietary Ferulic Acid Supplementation on Hepatic Injuries in Tianfu Broilers Challenged with Lipopolysaccharide

Toxins, 2022
Lipopolysaccharide (LPS) is an endotoxin that can cause an imbalance between the oxidation and antioxidant defense systems and then induces hepatic damages.
Gang Shu, Ziting Tang, Hong Du, Yilei Zheng, Lijen Chang, Haohuan Li, Funeng Xu, Hualin Fu, Wei Zhang, Juchun Lin   +9 more
doaj   +1 more source

Aripiprazole Attenuates Cognitive Impairments Induced by Lipopolysaccharide in Rats through the Regulation of Neuronal Inflammation, Oxidative Stress, and Apoptosis

Medicina, 2023
Background and Objectives: Aripiprazole (APZ), an atypical antipsychotic, is mainly prescribed for conditions such as schizophrenia and bipolar disorder, while ongoing research indicates promising neuroprotective qualities.
Vasudevan Mani, Bander Shehail Alshammeri   +1 more
doaj   +1 more source

Effects of Dietary Ferulic Acid on Intestinal Health and Ileal Microbiota of Tianfu Broilers Challenged with Lipopolysaccharide

Molecules, 2023
Lipopolysaccharide (LPS) has been considered the primary agent to establish animal models of inflammation, immunological stress, and organ injury. Previous studies have demonstrated that LPS impaired gastrointestinal development and disrupted intestinal ...
Ziting Tang, Gang Shu, Hong Du, Yilei Zheng, Hualin Fu, Wei Zhang, Cheng Lv, Funeng Xu, Haohuan Li, Ping Ouyang, Juchun Lin, Li-Jen Chang, Felix Kwame Amevor, Xiaoling Zhao   +13 more
doaj   +1 more source

Pathological and Therapeutic Approach to Endotoxin-Secreting Bacteria Involved in Periodontal Disease

Toxins, 2021
It is widely recognized that periodontal disease is an inflammatory entity of infectious origin, in which the immune activation of the host leads to the destruction of the supporting tissues of the tooth.
Rosalia Marcano, M. Ángeles Rojo, Damián Cordoba-Diaz, Manuel Garrosa   +3 more
doaj   +1 more source

Lipopolysaccharide antagonists

Immunology Today, 1992
Bacterial lipopolysaccharide (LPS) is a potent and pleiotropic stimulus of immune cells. LPS has important clinical relevance because it has a direct role in the pathogenesis of Gram-negative bacterial infection. The lipid A moiety of LPS is responsible for the toxic effects of LPS.
W A, Lynn, D T, Golenbock
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Phosphodiesterase 4B is essential for lipopolysaccharide-induced CC chemokine ligand 3 production in mouse macrophages

Journal of Medical Sciences, 2015
Background: Phosphodiesterase 4 (PDE4) inhibitors negatively modulate many inflammatory responses, and some of these pharmacological effects are mediated by inhibition of PDE4B in inflammatory cells.
Ciou-Rong Lai, Huan-Chu Lo, Yi-Ling Chen, Jing-Xing Yang, Shiau-Li Ding, Hsian-He Hsu, Marco Conti, Chin-Pyng Wu, S L Catherine Jin   +8 more
doaj   +1 more source

Nanocurcumine Ameliorates Lipopolysaccharide-induced Depressive-like Behavior in Mice [PDF]

Nanomedicine Research Journal, 2018
Objective(s): Curcumin, a plant alkaloid from Curcuma longa, possess antioxidant and anti-inflammatory properties. Recently, the antidepressant activities of curcumin were reported. Nevertheless, bioavailability of curcumin limits its therapeutic utility.
Nahid Fakhraei, Seyyedeh Elaheh Mousavi, Seyed Pouyan Pishva, Seyed Mahdi Rezayat, Fatemeh Mohammadi   +4 more
doaj   +1 more source