Results 1 to 10 of about 279,832 (297)
Frontiers in Immunology, 2022 A RhoA-specific guanine nucleotide exchange factor, p190RhoGEF, was first cloned and identified in neuronal cells. In immune cells, we first reported the role of p190RhoGEF in B cells: expression of p190RhoGEF increased after CD40 stimulation and was ...
So-Yeon Choi +4 more
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Gut-Derived Sterile Inflammation and Parkinson's Disease
Frontiers in Neurology, 2022 The etiology of Parkinson's disease (PD) is unknown, but evidence is increasing that there is a prominent inflammatory component to the illness. Epidemiological, genetic, and preclinical evidence support a role for gut-derived sterile inflammation.
Kathleen M. Shannon
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MYC Participates In Lipopolysaccharide-Induced Sepsis Via Promoting Cell Proliferation And Inhibiting Apoptosis [PDF]
Cell Journal, 2020 Objective This study aimed to explore the potential mechanism of MYC proto-oncogene, BHLH Transcription Factor (MYC) gene, on sepsis. Materials And Methods In this experimental study, rat-derived H9C2 cardiomyocyte cells were cultured in vitro ...
Yin Li +5 more
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Microglial Ultrastructure in the Hippocampus of a Lipopolysaccharide-Induced Sickness Mouse Model
Frontiers in Neuroscience, 2019 Sickness behavior is a set of behavioral changes induced by infections and mediated by pro-inflammatory cytokines. It is characterized by fatigue, decreased appetite and weight loss, changes in sleep patterns, cognitive functions, and lost interest in ...
Julie C. Savage +7 more
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Identification of Shiga toxin in patients with acute intestinal infections in the presence of mono- and mixed-O-antigens of pathogens [PDF]
Терапевтический архив, 2017 Aim. To investigate the time course of changes in the detection rates and levels of Shiga toxin antigen (STA) in their stool and middle-molecule circulating immune complexes (CICs) containing IgG (IgG CIC) in patients with acute intestinal infections ...
O F Belaia +6 more
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Remodeling of O Antigen in Mucoid
mBio, 2019 Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic lung infections in people with cystic fibrosis (CF). Chronic P. aeruginosa isolates generally do not express O antigen and often have a mucoid phenotype, which is characterized by ...
Ashley R. Cross, Joanna B. Goldberg
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Peptidoglycan Remodeling Enables
mBio, 2019 Gram-negative bacteria have a tripartite cell envelope with the cytoplasmic membrane (CM), a stress-bearing peptidoglycan (PG) layer, and the asymmetric outer membrane (OM) containing lipopolysaccharide (LPS) in the outer leaflet.
Niccolò Morè +12 more
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Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling
mSystems, 2017 Cohabitation of microbial communities with the host enables the formation of a symbiotic relationship that maintains homeostasis in the gut and beyond. One prevailing model suggests that this relationship relies on the capacity of host cells and tissues ...
Eva d’Hennezel +3 more
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Frontiers in Nutrition, 2020 Objective: To investigate the effect of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on lipopolysaccharide (LPS)-induced inflammatory response and oxidative stress in neonatal rat brain.Methods: Ninety-six 3-day-old Sprague Dawley rats were divided ...
Jipeng Shi +7 more
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Frontiers in Pharmacology, 2020 Intestinal barrier dysfunction contributes to the development of intestinal diseases. Propionic acid (PA), a metabolite generated by anaerobic fermentation of dietary fiber in the intestinal cavity, has been proved to exert anti-inflammatory effects in a
Randong Yang +6 more
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