Results 41 to 50 of about 351,832 (297)

The Lipopolysaccharide from Capnocytophaga canimorsus Reveals an Unexpected Role of the Core-Oligosaccharide in MD-2 Binding [PDF]

, 2012
Capnocytophaga canimorsus is a usual member of dog's mouths flora that causes rare but dramatic human infections after dog bites. We determined the structure of C. canimorsus lipid A.
Marco Stenta (167214), Dal Peraro, Matteo, Zähringer, Ulrich, Stenta Marco, Buko Lindner, Pablo Manfredi, Ittig Simon, Lindner, Buko, Zdorovenko, Evelina, Zähringer Ulrich, Knirel Yuriy A., Stenta, Marco, Knirel, Yuriy A., Simon Ittig, Cornelis Guy R., Buko Lindner (167210), Matteo dal Peraro (167235), Yuriy A Knirel, Knirel, Yuriy A, Zdorovenko Evelina, Lindner Buko, Manfredi, Pablo, Evelina Zdorovenko (167221), Simon Ittig (167206), Ulrich Zähringer, Yuriy A. Knirel (167229), Pablo Manfredi (158219), Cornelis, Guy R., Evelina Zdorovenko, Marco Stenta, Manfredi Pablo, Ittig, Simon, Cornelis, Guy R, Guy R. Cornelis (158232), Guy R Cornelis, Ulrich Zähringer (37778), Matteo dal Peraro, dal Peraro Matteo   +37 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Role of p52 (NF-κB2) in LPS tolerance in a human B cell line [PDF]

, 1999
Cells of the weakly CD14 positive human B cell line RPMI 8226, clone 1, will mobilize NF-κB (p50/p65 and p50/p50) proteins and produce TNF mRNA when stimulated with lipopolysaccharide (LPS), When such cells are precultured with a low amount of LPS (50 ...
Wedel, Angela, Sulski, Gabi, Kuprash, Dmitry, H.W. Loems Ziegler-Heitbrock, Angela Wedel, Marion Frankenberger, Irmhild Petersmann, Nedospasov, Sergei, Frankenberger, Marion, Petersmann, Irmhild, Ziegler-Heitbrock, H. W. Loems, Dmitry Kuprash, Sergei Nedospasov, Gabi Sulski   +13 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Identification of Potential Sepsis Therapeutic Drugs Using a Zebrafish Rapid Screening Approach

Life
In the military, combat wound infections can progress rapidly to life-threatening sepsis. The discovery of effective small-molecule drugs to prevent and/or treat sepsis is a priority.
Mark Widder, Chance Carbaugh, William van der Schalie, Ronald Miller, Linda Brennan, Ashley Moore, Robert Campbell, Kevin Akers, Roseanne Ressner, Monica Martin, Michael Madejczyk, Blair Dancy, Patricia Lee, Charlotte Lanteri   +13 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

The Bacterial Cell Wall Components Lipopolysaccharide and Peptidoglycan Initiate Divergent Local Tissue and Systemic Inflammatory Response Profiles in the Chicken Model

Animals
The innate immune system plays an important role in the defense against pathogens, whereby the ability to rapidly mount an effective inflammatory response is critical in the elimination/containment of the infection. To better understand the nature of the
Kristen A. Byrne, Gisela F. Erf
doaj   +1 more source

Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state [PDF]

, 2001
Background: Macrophages sense microorganisms through activation of members of the Toll-like receptor family, which initiate signals linked to transcription of many inflammation associated genes.
Aderem, A, Underhill David M, Ozinsky, A O, Underhill, D. M., Ozinsky, A.O., Sweet Matthew J, Hume, D A, Liew Foo Y, Sweet, M J, Underhill, D M, Liew, F Y, Liew, F.Y., Aderem, A., Sweet, M. J., Hume, D. A., Hume David A, Ozinsky Adrian O, Aderem Alan   +17 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source