Results 61 to 70 of about 519,050 (337)

Inhibition of specific signaling pathways rather than epigenetic silencing of effector genes is the leading mechanism of innate tolerance

Frontiers in Immunology, 2023
IntroductionMacrophages activated through a pattern-recognition receptor (PRR) enter a transient state of tolerance characterized by diminished responsiveness to restimulation of the same receptor. Signaling-based and epigenetic mechanisms are invoked to
Anna M. Masyutina, Anna M. Masyutina, Polina V. Maximchik, Georgy Z. Chkadua, Mikhail V. Pashenkov   +4 more
doaj   +1 more source

Porphyromonas gingivalis lipopolysaccharide alters atherosclerotic-related gene expression in oxidized low-density-lipoprotein-induced macrophages and foam cells [PDF]

, 2011
The molecular mechanism between atherosclerosis formation and periodontal pathogens is not clear although positive correlation between periodontal infections and cardiovascular diseases has been reported.
de Winther, Demmer, Diya, Fischer, Gamble, Ghosh, Giacona, Gibson, Gitlin, Groeneweg, Janabi, Kleemann, Lalla, Li, Lu, Ma, Majdalawieh, Martin, Mikita, Oram, Qi, Robbesyn, Ross, Zhou   +23 more
core   +2 more sources

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

Evaluating peripheral blood lymphocyte subset composition and lipopolysaccharide-induced cytokine secretory activity in mononuclear leukocyte cultures from patients with febrile and meningeal forms of tick-borne encephalitis

Инфекция и иммунитет
Introduction.Multiple studies on immune response in patients with various clinical forms of tick-borne encephalitis (TBE) have shown conflicting results.
Ekaterina N. Ilyinskikh, O. V. Voronkova, A. V. Reshetova, R. R. Hasanova, I. E. Esimova, N. A. Chernyshov, O. V. Yampolskaya, A. V. Yampolskaya, E. M. Polomoshnova, E. V. Minakova   +9 more
doaj   +1 more source

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, EarlyView.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source

Prenatal Immune Challenge Differentiates the Effect of Aripiprazole and Risperidone on CD200–CD200R and CX3CL1–CX3CR1 Dyads and Microglial Polarization: A Study in Organotypic Cortical Cultures

Life
Microglia are the primary innate immune cells of the central nervous system and extensively contribute to brain homeostasis. Dysfunctional or excessive activity of microglia may be associated with several neuropsychiatric disorders, including ...
Katarzyna Chamera, Katarzyna Curzytek, Kinga Kamińska, Monika Leśkiewicz, Agnieszka Basta-Kaim   +4 more
doaj   +1 more source

Lipopolysaccharide structure modulates cationic biocide susceptibility and crystalline biofilm formation in Proteus mirabilis

Frontiers in Microbiology, 2023
Chlorhexidine (CHD) is a cationic biocide used ubiquitously in healthcare settings. Proteus mirabilis, an important pathogen of the catheterized urinary tract, and isolates of this species are often described as “resistant” to CHD-containing products ...
O. E. Clarke, H. Pelling, V. Bennett, T. Matsumoto, G. E. Gregory, J. Nzakizwanayo, A. J. Slate, A. Preston, M. Laabei, L. J. Bock, M. E. Wand, K. Ikebukuro, S. Gebhard, J. M. Sutton, B. V. Jones   +14 more
doaj   +1 more source

Downregulation of Tumor Necrosis Factor Expression in the Human Mono-Mac-6 Cell Line [PDF]

, 1989
Mono-Mac-6 cells, but not U937 cells, can be Induced to rapidly express tumor necrosis factor (TNF) mRNA and protein when triggered with Ilpopolysaccharlde (LPS) at 1 pg/mI. Preincubatlon of the cells for 3 d with low amounts of LPS (10 ng/mI) results In
Blömer, Kathi, Haas, Jürgen G., Riethmüller, Gert, Thiel, Corinna, Weiss, Elisabeth H., Ziegler-Heitbrock, H. W. Löms   +5 more
core   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Diesel Exhaust Activates & Primes Microglia: Air Pollution, Neuroinflammation, & Regulation of Dopaminergic Neurotoxicity [PDF]

, 2011
BACKGROUND: Air pollution is linked to central nervous system disease, but the mechanisms responsible are poorly understood. OBJECTIVES: Here, we sought to address the brain-region-specific effects of diesel exhaust (DE) and key cellular mechanisms ...
Block, Michelle L, Duke, Laura, Johnson, Jo Anne, Kodavanti, Prasada, Kodavanti, Urmila, Levesque, Shannon, Lull, Melinda E., Stadler, Krisztian, Surace, Michael J., Taetzsch, Thomas, Wagner, Alison   +10 more
core   +1 more source