Results 81 to 90 of about 264,633 (217)

Cordyceps militaris extract and cordycepin ameliorate LPS-challenged colonic damage in piglets by modulating the microbiota and metabolite profiles

Frontiers in Immunology
IntroductionCordyceps militaris extract (CME) and cordycepin (CPN) are biomolecules with a wide range of biological activities, including anti-inflammatory, antioxidant and anti-tumour effects.
Shijie Xiong, Shijie Xiong, Fan Wan, Fan Wan, Jiajia Jiang, Yanfang Liu, Yiqiong Hang, Huiqin Xue, Yang Lu, Yang Lu, Yong Su   +10 more
doaj   +1 more source

Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform

Advanced Science, EarlyView.
We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng, Jiahao Lin, Qiushuang Zhang, Xiangdong Zhang, Yicong Dai, Jinghong Li   +5 more
wiley   +1 more source

Modulating effects of Phellinus linteus polysaccharides on antioxidant capacity, immune function, intestinal function and microbiota in lipopolysaccharide-challenged broilers

Frontiers in Microbiology
Phellinus linteus polysaccharides (PLP) have been shown to have beneficial effects on gut function and gut microbiota in animals. The intention of this study was to examine the effects of PLP on growth performance, immune function, intestinal barrier ...
Yang Li, Shuai Wang, Xuran Zhu, Nana Gao, Jungang Kang, Tianxiong Wang, Xiaodan Wang   +6 more
doaj   +1 more source

Dual‐Network Protein Hydrogels Promote Rapid Hemostasis and Immune‐Regulated Scarless Tissue Regeneration

Advanced Science, EarlyView.
A dual‐network protein hydrogel substantially improves hemostasis and scar‐free healing.The adaptive network maintains intimate tissue contact while providing strong wet adhesion, tunable mechanics, and controlled degradation. Concurrent ROS scavenging and M2 polarization suppress fibrotic pathways, preventing scar formation.
Xiaomei Li, Guorui Zhang, Xinyue Wang, Zhongyu Liu, Ling Yang, Yuhan Bao, Min Wei, Yonglin Chen, Yanfei Ma, Wenbo Sheng, Bo Yu, Bin Li   +11 more
wiley   +1 more source

Recognition of Porphyromonas gingivalis lipopolysaccharide by human caspase−4 depends on lipopolysaccharide purity and guanylate-binding protein 1

Journal of Oral Microbiology
Background Porphyromonas gingivalis, a key pathogen in chronic periodontitis, produces heterogeneous lipopolysaccharides (LPS) that are weakly recognized by Toll-like receptor 4 (TLR4).
Eisuke Domae, Taiki Mori, Mariko Hanaoka, Takeshi Into   +3 more
doaj   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

The Porphyromonas gingivalis lipid A 1-phosphatase LpxE requires a functional type IX secretion system for its activity

Journal of Oral Microbiology
Background: Porphyromonas gingivalis is a Gram-negative bacterium that plays a central role in the development of periodontal disease. It uses a type IX secretion system (T9SS) to export virulence factors to the bacterial surface where they are attached ...
Sunjun Wang, Yichao Liu, Beichang Zhang, Joseph Aduse-Opoku, Roberto Buccafusca, Oscar Ayrton, Giulia Mastroianni, Pedro Machado, Mark A. J. Roberts, Michael A. Curtis, James A. Garnett   +10 more
doaj   +1 more source

Dual Physiological Barriers Bypassed by a Silk‐Based Supramolecular Protein Delivery Platform for Neuroinflammation Mitigation in Alzheimer's Disease

Advanced Science, EarlyView.
A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu, Tiandong Li, Jian He, Yujian Jiang, Yeyuan Wang, Jingchen Sun   +5 more
wiley   +1 more source

Effects of Dietary Gallic Acid on Growth Performance, Meat Quality, Antioxidant Capacity, and Muscle Fiber Type-Related Gene Expression in Broiler Chickens Challenged with Lipopolysaccharide

Animals
In this study, broilers were selected as the research object to investigate the effects and mechanisms of dietary gallic acid (GA) supplementation on growth performance, meat quality, antioxidant capacity, and muscle fiber-related gene expression.
Taidi Xiong, Zhilong Chen, Mubashar Hassan, Cui Zhu, Junyan Wang, Shujun Tan, Fayuan Ding, Zhonggang Cheng, Jinling Ye, Qiuli Fan, Danlei Xu, Shouqun Jiang, Dong Ruan   +12 more
doaj   +1 more source

Interface Wettability Transition‐Driven Drug Release and Dual‐Phase Functionalization in Implant Abutment

Advanced Science, EarlyView.
A temporally controlled drug release coating is developed for abutments using a superhydrophobic coating self‐assembled on mesoporous silica. This surface provides sequential functionality: initial contamination resistance through non‐wetting, followed by controlled drug release via wettability transition.
Zhongchao Wang, Liang Shi, MingXia Li, Xiao Han, Jinghan Wang, Guangping Wang, Dan Zou, Bingyang Lu, Liyuan Fan   +8 more
wiley   +1 more source