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Lipoprotein(a) [PDF]

MMW - Fortschritte der Medizin, 2021
AbstractLipoprotein(a) [Lp(a)] is an atherogenic lipoprotein with a strong genetic regulation. Up to 90% of the concentrations are explained by a single gene, theLPAgene. The concentrations show a several-hundred-fold interindividual variability ranging from less than 0.1 mg/dL to more than 300 mg/dL. Lp(a) plasma concentrations above 30 mg/dL and even
openaire   +4 more sources

Effects of deletion of the Streptococcus pneumoniae lipoprotein diacylglyceryl transferase gene lgt on ABC transporter function and on growth in vivo [PDF]

, 2012
Lipoproteins are an important class of surface associated proteins that have diverse roles and frequently are involved in the virulence of bacterial pathogens.
A Bidossi, A Cockayne, A Dintilhac, A Hamilton, A Hiron, A Kadioglu, A Marra, A Polissi, A Yoshimura, AJ Link, AJ Standish, Alain Charbit, AM van Rossum, AW Segal, BA Bray, C Bordier, C Hyams, C Marion, CJ Orihuela, Claire Durmort, CM Petit, D Burnette-Curley, D Ware, DC Desrosiers, DL Hava, E Loisel, E Loisel, EM Eriksson, Emilie Camberlein, FE Jacobsen, GW Lau, H Echchannaoui, H Stoll, H Tettelin, H Tjalsma, H Yamagata, HD Brightbill, HJ Tseng, HM Marriott, IC Sutcliffe, IM Jonsson, J Bubeck Wardenburg, J McCluskey, J Sambrook, Jeremy S. Brown, JM Cohen, Jonathan M. Cohen, JS Brown, JS Brown, JS Brown, JS Brown, K Gan, K Overweg, K Sankaran, KR Gee, L Bayle, L Richards, LJ McAllister, LS Havarstein, M Baumgartner, M Jomaa, M Schmaler, M Tokunaga, N Banaiee, Nathanael MacDonald, P Henneke, P Petrarca, Peter W. M. Hermans, PJ Wichgers Schreur, PW Hermans, R Gabbianelli, R Janulczyk, R Malley, RJ Pezza, S Basavanna, S Bergmann, S Chimalapati, S Das, S Dawid, S Inouye, S Khandavilli, S Knapp, S Leskela, S Machata, SA Lacks, Suneeta Chimalapati, T Arimoto, TE Molzen, Thierry Vernet, Timothy Mitchell, U Koedel, U Samen   +91 more
core   +12 more sources

Acute and chronic effects on cholesterol biosynthesis of LDL-apheresis with or without concomitant HMG-CoA reductase inhibitor therapy.

Journal of Lipid Research, 1994
To determine the acute and long-term effects of low density lipoprotein (LDL) reduction on cholesterol biosynthesis, we studied changes in the cholesterol precursors mevalonic acid (MVA) and lathosterol in patients with heterozygous familial ...
M Pfohl, R P Naoumova, C Klass, W Knisel, B Jakober, T Risler, G R Thompson   +6 more
doaj   +1 more source

Alterations of intestinal lipoprotein metabolism in diabetes mellitus and metabolic syndrome [PDF]

, 2015
Diabetes and metabolic syndrome are associated with abnormal postprandial lipoprotein metabolism, with a significant delay in the clearance of many lipid parameters, including triglycerides and chylomicrons.
ARCA, Marcello
core   +1 more source

Characterization of two new point mutations in the low density lipoprotein receptor genes of an English patient with homozygous familial hypercholesterolemia.

Journal of Lipid Research, 1992
Two new point mutations have been detected in the low density lipoprotein (LDL) receptor gene of a patient with a clinical diagnosis of homozygous familial hypercholesterolemia (FH).
JC Webb, XM Sun, DD Patel, SN McCarthy, BL Knight, AK Soutar   +5 more
doaj   +1 more source

An integrated mathematical model of cellular cholesterol biosynthesis and lipoprotein metabolism [PDF]

, 2018
Cholesterol regulation is an important aspect of human health. In this work we bring together and extend two recent mathematical models describing cholesterol biosynthesis and lipoprotein endocytosis to create an integrated model of lipoprotein ...
Pool, Frances, Sweby, Peter K., Tindall, Marcus J.   +2 more
core   +2 more sources

Cholesteryl ester transfer protein and high density lipoprotein responses to cholesterol feeding in men: relationship to apolipoprotein E genotype.

Journal of Lipid Research, 1993
The apolipoprotein (apo) E isoform is an important determinant of the plasma lipoprotein distribution of apoE and of the metabolism of apoE-containing lipoproteins.
LJ Martin, PW Connelly, D Nancoo, N Wood, ZJ Zhang, G Maguire, E Quinet, AR Tall, YL Marcel, R McPherson   +9 more
doaj   +1 more source

Coronary artery endothelial dysfunction is positively correlated with low density lipoprotein and inversely correlated with high density lipoprotein subclass particles measured by nuclear magnetic resonance spectroscopy. [PDF]

, 2009
OBJECTIVE: The association between cholesterol and endothelial dysfunction remains controversial. We tested the hypothesis that lipoprotein subclasses are associated with coronary endothelial dysfunction.
Abhiram Prasad, Amir Lerman, Anderson, Barter, Blake, Bonetti, Cannon, Chait, Charanjit S. Rihal, Colhoun, Cromwell, Deanfield, El Harchaoui, Ford, Forrest, Gurpreet S. Sandhu, Hartman, Hermann, Jeyarajah, Johansson, Joseph P. McConnell, Kathiresan, Kuller, Kuller, Lavi, Lavi, Lerman, Lilach O. Lerman, Mackey, Mackey, Monique A. Ford, Mora, Mora, Otvos, Rosenson, Shahar Lavi, Sirtori, Stacy J. Hartman, Suwaidi, Vakkilainen, van der Steeg, Vergeer, Woodman   +42 more
core   +1 more source

Behavior of human apolipoprotein A-I: phospholipid and apoHDL:phospholipid complexes in vitro and after injection into rabbits

Journal of Lipid Research, 1988
Apolipoprotein A-I was purified from human high density lipoprotein and complexed with polyunsaturated phosphatidylcholine (PC) in deoxycholate (Lipostabil); the bile salt was removed subsequently by dialysis.
J Koizumi, M Kano, K Okabayashi, A Jadhav, G R Thompson   +4 more
doaj   +1 more source

Influence of different fat emulsions with 10 or 20% MCT/LCT or LCT on lipoproteins in plasma of patients after abdominal surgery [PDF]

, 1998
In patients after elective abdominal surgery, different fat emulsions were used to compare their efficacy in total parenteral nutrition and in normalizing plasma lipoprotein levels.
Hailer, Susanne, Jauch, Karl-Walter, Wolfram, Günther   +2 more
core   +1 more source