Results 1 to 10 of about 999,472 (383)

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis

PLoS Medicine, 2020
Background Circulating lipoprotein lipids cause coronary heart disease (CHD). However, the precise way in which one or more lipoprotein lipid-related entities account for this relationship remains unclear.
Tom G Richardson, Eleanor Sanderson, Tom Palmer   +2 more
exaly   +2 more sources

Immunochemical studies on human plasma lipoproteins [PDF]

, 1957
Some years ago, a series of human serum lipoproteins, distinguishable by their hydrated densities and lipid-protein ratios were recognized and isolated by ultracentrifugal techniques (1).
Aladjem, Frederick, Gofman, W., Lieberman, Miriam   +2 more
core   +3 more sources

Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease.

New England Journal of Medicine, 2022
BACKGROUND Lipoprotein(a) is a presumed risk factor for atherosclerotic cardiovascular disease. Olpasiran is a small interfering RNA that reduces lipoprotein(a) synthesis in the liver. METHODS We conducted a randomized, double-blind, placebo-controlled,
M. O’Donoghue, R. Rosenson, B. Gencer, J. A. López, N. Lepor, S. Baum, Elmer Stout, D. Gaudet, B. Knusel, J. Kuder, Xinhui Ran, S. Murphy, Hong Wang, You Wu, H. Kassahun, M. Sabatine   +15 more
semanticscholar   +1 more source

Small Dense Low‐Density Lipoprotein Cholesterol Is the Most Atherogenic Lipoprotein Parameter in the Prospective Framingham Offspring Study

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2021
Background Elevated plasma levels of direct low‐density lipoprotein cholesterol (LDL‐C), small dense LDL‐C (sdLDL‐C), low‐density lipoprotein (LDL) triglycerides, triglycerides, triglyceride‐rich lipoprotein cholesterol, remnant lipoprotein particle ...
H. Ikezaki, E. Lim, L. Cupples, Ching‐Ti Liu, B. Asztalos, E. Schaefer   +5 more
semanticscholar   +1 more source

Lipoprotein(a) Reduction in Persons with Cardiovascular Disease.

New England Journal of Medicine, 2020
BACKGROUND Lipoprotein(a) levels are genetically determined and, when elevated, are a risk factor for cardiovascular disease and aortic stenosis. There are no approved pharmacologic therapies to lower lipoprotein(a) levels.
S. Tsimikas, E. Karwatowska-Prokopczuk, I. Gouni-Berthold, J. Tardif, S. Baum, E. Steinhagen-Thiessen, M. Shapiro, E. Stroes, P. Moriarty, B. Nordestgaard, S. Xia, J. Guerriero, N. Viney, L. O’Dea, J. Witztum   +14 more
semanticscholar   +1 more source

Statin therapy increases lipoprotein(a) levels.

European Heart Journal, 2020
AIMS Lipoprotein(a) [Lp(a)] is elevated in 20-30% of people. This study aimed to assess the effect of statins on Lp(a) levels. METHODS AND RESULTS This subject-level meta-analysis includes 5256 patients (1371 on placebo and 3885 on statin) from six ...
S. Tsimikas, P. Gordts, Chelsea L. Nora, C. Yeang, J. Witztum   +4 more
semanticscholar   +1 more source

Lp(a) (Lipoprotein[a]) Concentrations and Incident Atherosclerotic Cardiovascular Disease

Arteriosclerosis, Thrombosis and Vascular Biology, 2020
Supplemental Digital Content is available in the text. Objective: Lp(a) (lipoprotein[a]) concentrations are associated with atherosclerotic cardiovascular disease (ASCVD), and new therapies that enable potent and specific reduction are in development. In
A. Patel, Minxian Wang, J. Pirruccello, P. Ellinor, Kenney Ng, S. Kathiresan, A. Khera   +6 more
semanticscholar   +1 more source

Alterations of intestinal lipoprotein metabolism in diabetes mellitus and metabolic syndrome [PDF]

, 2015
Diabetes and metabolic syndrome are associated with abnormal postprandial lipoprotein metabolism, with a significant delay in the clearance of many lipid parameters, including triglycerides and chylomicrons.
ARCA, Marcello
core   +1 more source

Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.

Clinical Chemistry, 1972
A method for estimating the cholesterol content of the serum low-density lipoprotein fraction (Sf0-20) is presented. The method involves measurements of fasting plasma total cholesterol, triglyceride, and high-density lipoprotein cholesterol ...
W. T. Friedewald, R. Levy, D. Fredrickson   +2 more
semanticscholar   +1 more source

An integrated mathematical model of cellular cholesterol biosynthesis and lipoprotein metabolism [PDF]

, 2018
Cholesterol regulation is an important aspect of human health. In this work we bring together and extend two recent mathematical models describing cholesterol biosynthesis and lipoprotein endocytosis to create an integrated model of lipoprotein ...
Pool, Frances, Sweby, Peter K., Tindall, Marcus J.   +2 more
core   +2 more sources