Results 61 to 70 of about 864,255 (364)

Roles of reconstituted high-density lipoprotein nanoparticles in cardiovascular disease: A new paradigm for drug discovery [PDF]

, 2020
Epidemiological results revealed that there is an inverse correlation between high-density lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease (ASCVD).
Huang, Hui, Huang, Jiansheng, Huang, Li-Hao, Wang, Dongdong   +3 more
core   +2 more sources

Structure, function, and genetics of lipoprotein (a)

Journal of Lipid Research, 2016
Lipoprotein (a) [Lp(a)] has attracted the interest of researchers and physicians due to its intriguing properties, including an intragenic multiallelic copy number variation in the LPA gene and the strong association with coronary heart disease (CHD ...
K. Schmidt, A. Noureen, F. Kronenberg, G. Utermann   +3 more
semanticscholar   +1 more source

Tryptophan‐sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin‐producing cells

FEBS Open Bio, EarlyView.
GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda, Hiroshi Iwakura, Takuya Ensho, Mika Bando‐Shimizu, Asako Doi, Norihiko Matsutani, Shuhei Morita, Hidefumi Inaba, Hiroyuki Ariyasu, Naoki Fukuda, Keiji Hayata, Toshiyasu Ojima, Masahiro Nishi, Taka‐aki Matsuoka, Hiroki Yamaue, Takashi Akamizu   +15 more
wiley   +1 more source

Acute and chronic effects on cholesterol biosynthesis of LDL-apheresis with or without concomitant HMG-CoA reductase inhibitor therapy.

Journal of Lipid Research, 1994
To determine the acute and long-term effects of low density lipoprotein (LDL) reduction on cholesterol biosynthesis, we studied changes in the cholesterol precursors mevalonic acid (MVA) and lathosterol in patients with heterozygous familial ...
M Pfohl, R P Naoumova, C Klass, W Knisel, B Jakober, T Risler, G R Thompson   +6 more
doaj  

Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection

Scientific Reports, 2016
Circulating extracellular vesicles have emerged as potential new biomarkers in a wide variety of diseases. Despite the increasing interest, their isolation and purification from body fluids remains challenging.
Barbara W. Sódar, Á. Kittel, K. Pálóczi, Krisztina V. Vukman, X. Osteikoetxea, K. Szabó-Taylor, A. Németh, B. Sperlágh, T. Baranyai, Z. Giricz, Z. Wiener, Lilla Turiák, L. Drahos, É. Pállinger, K. Vékey, P. Ferdinandy, A. Falus, E. Buzás   +17 more
semanticscholar   +1 more source

Mapping Hsp104 interactions using cross‐linking mass spectrometry

FEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal, Karolina Michalska, Andrzej Joachimiak, Lukasz A. Joachimiak   +3 more
wiley   +1 more source

Characterization of two new point mutations in the low density lipoprotein receptor genes of an English patient with homozygous familial hypercholesterolemia.

Journal of Lipid Research, 1992
Two new point mutations have been detected in the low density lipoprotein (LDL) receptor gene of a patient with a clinical diagnosis of homozygous familial hypercholesterolemia (FH).
JC Webb, XM Sun, DD Patel, SN McCarthy, BL Knight, AK Soutar   +5 more
doaj  

Quantitative Lipoprotein Subclass and Low Molecular Weight Metabolite Analysis in Human Serum and Plasma by 1H NMR Spectroscopy in a Multilaboratory Trial.

Analytical Chemistry, 2018
We report an extensive 600 MHz NMR trial of quantitative lipoprotein and small-molecule measurements in human blood serum and plasma. Five centers with eleven 600 MHz NMR spectrometers were used to analyze 98 samples including 20 quality controls (QCs ...
B. Jiménez, E. Holmes, C. Heude, Rose F Tolson, Nikita Harvey, S. Lodge, Andrew J Chetwynd, C. Cannet, Fang Fang, Jake T. M. Pearce, M. Lewis, M. Viant, J. Lindon, M. Spraul, H. Schäfer, J. Nicholson   +15 more
semanticscholar   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Cholesteryl ester transfer protein and high density lipoprotein responses to cholesterol feeding in men: relationship to apolipoprotein E genotype.

Journal of Lipid Research, 1993
The apolipoprotein (apo) E isoform is an important determinant of the plasma lipoprotein distribution of apoE and of the metabolism of apoE-containing lipoproteins.
LJ Martin, PW Connelly, D Nancoo, N Wood, ZJ Zhang, G Maguire, E Quinet, AR Tall, YL Marcel, R McPherson   +9 more
doaj