Results 211 to 220 of about 24,826 (263)
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Lipoprotein Lp(a) and Atherothrombotic Disease
Archives of Medical Research, 2000High plasma concentrations of lipoprotein (a) [Lp(a)] are now considered a major risk factor for atherosclerosis and cardiovascular disease. This effect of Lp(a) may be related to its composite structure, a plasminogen-like inactive serine-proteinase, apoprotein (a) [apo(a)], which is disulfide-linked to the apoprotein B100 of an atherogenic low ...
A, de la Peña-Díaz +2 more
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Studies on the Lp(a)-lipoprotein of human serum
Humangenetik, 1972Lp(a)-lipoprotein of human serum, when isolated by ultracentrifugation and gelfiltration on Sepharose 4 B, may disaggregate into several components either spontaneously or by mild treatment with detergents:
G, Utermann, K, Lipp, H, Wiegandt
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Lp(a) lipoprotein: An overview
Chemistry and Physics of Lipids, 1990The Lp(a) lipoprotein, a distinct class of serum lipoproteins, was detected in 1962. It consists of an LDL particle to which a long polypeptide chain is attached by a disulfide bridge. The level of Lp(a) lipoprotein is genetically determined. Single locus control was suggested already in the very first report, and this has been conclusively confirmed ...
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Oxidation of lipoprotein Lp(a). A comparison with low-density lipoproteins
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1991Aimed at identifying possible mechanisms of the suggested high atherogenicity of Lp(a), its susceptibility for Cu(II)-induced oxidation was studied and compared with that of LDL. Since the content of antioxidants as well as the fatty acid pattern of a lipoprotein greatly affects its oxidizability, Lp(a) and LDL were characterized first with respect to ...
W, Sattler +3 more
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Genetics of the quantitative Lp(a) lipoprotein trait
Human Genetics, 1988The Lp(a) lipoprotein is a complex particle composed of a low density lipoprotein (LDL)-like lipoprotein and the disulfide bonded Lp(a) glycoprotein. The complex represents a quantitative genetic trait. SDS gel electrophoresis under reducing conditions of sera followed by immunoblotting with affinity-purified polyclonal anti-Lp(a) demonstrated inter ...
G, Utermann +4 more
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Uptake of Lp(a) lipoprotein by cultured fibroblasts
Biochemical and Biophysical Research Communications, 1981Summary Lp(a) lipoprotein is bound and taken up by cultured human fibroblasts and increases cell cholesterol content and cholesterol esterification. The increase in cell cholesterol content and cholesterol esterification in low density lipoprotein receptor negative cells was minimal, which suggests that Lp(a) lipoprotein was taken up by the low ...
C H, Floren, J J, Albers, E L, Bierman
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Lp(a) Lipoprotein in Cerebrovascular Disease and Dementia
Psychiatry and Clinical Neurosciences, 1987Abstract: Lp(a) lipoprotein has been considered an independent risk factor in the development of coronary heart disease (CHD). We examined the role of Lp(a) in patients with cerebrovascular disease (CVD) and those with dementia.The Lp(a) concentration in patients with CHD, those with cerebral infarction due to a large artery occlusion and those with ...
K, Urakami, T, Mura, K, Takahashi
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Lp(a) Lipoprotein — Coping with Heterogeneity
New England Journal of Medicine, 2003In persons who are fasting, lipids circulate in the plasma as constituents of lipoprotein particles that are defined on the basis of their density as very-low-, intermediate-, low-, and high-densit...
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Lipoprotein Lp(a) and the risk for myocardial infarction
Atherosclerosis, 1981Abstract The serum lipoprotein Lp(a) concentration was measured in 76 male post-myocardial infarction (MI) patients aged between 40 and 60 years, and in 107 control subjects of the same age and sex. Quantitation was performed by the Laurell technique. It was sensitive in the range 1–60 mg/dl with a day to day C. V. of less than 4%.
G M, Kostner +5 more
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Lp(a) lipoprotein in cardiovascular disease
Atherosclerosis, 1994The article summarizes the increased knowledge about the enigmatic Lp(a) lipoprotein and its clinical importance over the past 20 years. The mode of inheritance, the unique features of Lp(a) composition and structure and the unusual distribution of the mainly genetically determined plasma Lp(a) levels are discussed.
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