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Studies on the metabolism of the lipoprotein Lp(a) in man
Atherosclerosis, 1978Lp(a) was isolated and labeled by reductive alkylation. Radioactivity only entered the protein moiety of the lipoprotein. No change in the immunological or physicochemical properties of Lp(a) was noted after the radiomethylation. After incubation of labeled Lp(a) with whole serum for 24 h in vitro, more than 99% of the radioactivity of the incubated ...
F, Krempler +3 more
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CHARACTERIZATION OF THE Lp(a) LIPOPROTEIN IN HUMAN PLASMA
Acta Pathologica Microbiologica Scandinavica Section B Microbiology and Immunology, 1970The Lp(a) lipoprotein from human plasma of Lp(a+) phenotype was isolated by preparative ultracentrifugation and Sepharose 2B gel filtration. The lipoprotein was found in the plasma fraction with a density of 1,05–1.12 g/ml, and had pre‐beta mobility in agarose clectrophoresis.
K, Simons +3 more
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Genetics of the Lp lipoprotein in Japanese‐Americans
Genetic Epidemiology, 1985AbstractSegregation analysis of four Lp assays on 557 children in 227 families reveals a dominant major gene and a residual heritable component that may reflect one or more alleles of weaker effect. Close or moderate linkage to esterase‐D (ESD) is excluded.
Newton E. Morton +5 more
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On the metabolism of lipoprotein-X (LP-X)
Clinica Chimica Acta, 1976The characteristic low-density lipoprotein of cholestasis (LP-X) earlier described for humans is found with identical properties in dogs and rats after experimental cholestasis. After ligation of the common bile duct, LP-X may be detected in the plasma within the first 20 hours.
D, Seidel +3 more
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Triglyceride-rich lipoprotein interactions with Lp(a)
Chemistry and Physics of Lipids, 1994We found a significantly reduced incidence of increased lipoprotein(a) (Lp(a)) levels in subjects with triglycerides (TG) greater than 150 mg/dl compared with those with TG levels lower than 150 mg/dl. This was the case in patients with angiographically documented coronary artery disease (CAD) and in subjects with no CAD. We explored the potential role
W J, McConathy +4 more
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Lipoprotein [Lp(a)] and peripheral vascular disease
Journal of Internal Medicine, 1992Lipoprotein(a) [Lp(a)], which combines structural elements of the lipid and fibrinolytic systems, is a major independent risk factor for the development of coronary heart disease. Eighty‐four consecutive patients with peripheral vascular disease (of whom 42 had concomitant ischaemic heart disease) and 43 healthy controls were enrolled in a case‐control
J, Tyrrell +7 more
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Linkage between the loci for the Lp(a) lipoprotein (LP) and plasminogen (PLG)
Human Genetics, 1988A locus, LP, that determines quantitative variation of Lp(a) lipoprotein phenotypes is linked to the plasminogen (PLG) locus (peak lod score = 12.73). This linkage relationship assigns a locus with alleles that have an affect on risk for coronary artery disease to the long arm of chromosome 6.
L R, Weitkamp +2 more
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Lp(a) lipoprotein links to diabetic mortality
Nursing Standard, 1991Increased concentrations of Lp(a) lipoprotein might partly explain the increased morbidity and mortality from cardiovascular disease in patients with diabetic nephropathy.
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Hyperlipoproteinemia of lipoprotein Lp(a)
1990Lp(a) is a lipoprotein with unknown physiological role. All we know for sure is that individuals with high Lp(a) levels are at an increased atherosclerosis risk. The Lp(a) plasma concentration correlates inversly with the molecular weight of the apo-a isoform; this is valid, however, only in healthy persons belonging to one ethnic group. Diseases, e.g.
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