Results 131 to 140 of about 93,526 (325)

Mechanism of triglyceride accumulation in rat preadipocyte cultures exposed to very low density lipoprotein.

Journal of Lipid Research, 1981
Cultured preadipocytes derived from the stromal-vascular fraction of adipose tissue have been shown to accumulate sufficient triglycerides to assume adipocyte morphology when exposed to high concentrations of very low density lipoprotein.
M de la Llera, J M Glick, G Rothblat
doaj   +1 more source

Using Ontology Fingerprints to evaluate genome-wide association study results [PDF]

, 2009
We describe an approach to characterize genes or phenotypes via ontology fingerprints which are composed of Gene Ontology (GO) terms overrepresented among those PubMed abstracts linked to the genes or phenotypes. We then quantify the biological relevance
Lam C. Tsoi, Michael Boehnke, Richard L. Klein, W. Jim Zheng   +3 more
core   +1 more source

Efficacy and safety of CT‐868, a novel, fully biased, dual glucagon‐like peptide‐1/glucose‐dependent insulinotropic polypeptide receptor agonist, in type 2 diabetes: A double‐blind, randomized placebo controlled phase 2 trial

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims To assess the glycaemic efficacy and safety of CT‐868, a cAMP signal‐biased, dual glucagon‐like peptide‐1/glucose‐dependent insulinotropic polypeptide receptor agonist, in participants with type 2 diabetes (T2D). Materials and Methods This 26‐week (W), phase 2, randomized, double‐blind placebo‐controlled trial enrolled adults with T2D ...
Manu V. Chakravarthy, Michael A. Elliott, Luis Acosta, Gabriele E. Sonnenberg, Damian Bialonczyk, Jingtao Wu, Federico A. Argüelles‐Tello, Raymundo Garcia‐Reza, José Gerardo González‐González, Stig K. Hansen, Juan P. Frias   +10 more
wiley   +1 more source

Lipid Metabolism and Comparative Genomics [PDF]

, 2006
Unilever asked the Study Group to focus on two problems. The first concerned dysregulated lipid metabolism which is a feature of many diseases including metabolic syndrome, obesity and coronary heart disease.
Jones, Janette, Melrose, John, O’Malley, Brendan, Pickersgill, Laura, Rougier, Jonathan, Tindall, Marcus   +5 more
core  

Efficacy and safety in tirzepatide‐treated Korean adults with type 2 diabetes—A post hoc analysis of SURPASS‐AP‐combo and SURPASS‐3

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims This post hoc analysis assessed the efficacy and safety data in tirzepatide‐treated Korean patients with type 2 diabetes (T2D). Materials and Methods Data specifically from Korean patients treated with tirzepatide 5, 10, or 15 mg in the multicentre, randomised, open‐label, parallel‐group, phase 3 trials SURPASS‐AP‐Combo and SURPASS‐3 were
Byung Wan Lee, Chang Beom Lee, Soo Lim, Sin Gon Kim, Nan Hee Kim, Jong Chul Won, Woo Je Lee, Min Ju Kang, Ju Young Yuh, Li Ying Du, Hyojin Lim, Kyu Jeung Ahn   +11 more
wiley   +1 more source

Adipose Tissue Lipoprotein Lipase Activity in Rats of Two Different Ages [PDF]

, 1962
C. Chlouverakis
openalex   +1 more source

Repurposing colchicine for reduction of residual inflammatory risk in type 1 diabetes: Design and rationale of the REC1TE trial

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Compared to people without diabetes, individuals with type 1 diabetes have a several‐fold increased risk of cardiovascular (CV) morbidity and mortality despite guideline‐recommended management of traditional risk factors; so‐called residual CV risk.
David S. Mathiesen, Josefine V. Hansen, Aske Høck, Casper K. Nielsen, Miriam G. Pedersen, Peter L. Kristensen, Henrik U. Andersen, Marie Louise Aarestrup, Julie L. Forman, Jonatan I. Bagger, Thomas F. Dejgaard, Filip K. Knop, Nicklas J. Johansen, Asger B. Lund   +13 more
wiley   +1 more source

Cellular responses to thermal stress and moderate oxygen limitation in juvenile lake trout

Journal of Fish Biology, EarlyView.
Abstract Lake trout (Salvelinus namaycush) is an important food fish in northern communities, inhabiting cool, well‐oxygenated water, but climate change is reducing available habitat, with extended summer stratification of lakes creating an upper thermal barrier (~15°C) and lower dissolved oxygen (DO) boundary (4–7 mg L−1).
Alyssa M. Weinrauch, Analisa Lazaro‐Côté, Travis C. Durhack, Eva C. Enders, Ken M. Jeffries   +4 more
wiley   +1 more source

CHANGES IN BLOOD COAGULATION DURING THE CLEARING OF LIPID EMULSIONS BY LIPOPROTEIN LIPASE [PDF]

, 1960
Robert L. Hirsch, Aaron Kellner, Rosemary Ireland   +2 more
openalex   +1 more source

Is Adipose Tissue Inflammation the Culprit of Obesity‐Associated Comorbidities?

Obesity Reviews, EarlyView.
ABSTRACT In individuals with obesity, the onset of chronic comorbidities coincides with the excessive accumulation of adipose tissue in various tissue beds. As obesity progresses, adipose tissue becomes increasingly dysfunctional causing chronic low‐grade inflammation.
Laurent Turner, Anjalee I. Wanasinghe, Pamela Brunori, Sylvia Santosa   +3 more
wiley   +1 more source