The role of fibroblast growth factors in cell and cancer metabolism
FEBS Letters, Volume 600, Issue 2, Page 140-163, January 2026.Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley +1 more source
Tirzepatide Therapy in a Patient with Type 2 Diabetes Mellitus, Chylomicronemia, and Heterozygosity for Lipoprotein Lipase Deficiency [PDF]
, 2023 Stephan P. Babirak
openalex +1 more source
FEBS Open Bio, Volume 16, Issue 1, Page 145-160, January 2026.Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao +7 more
wiley +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
CIDEC Restricts Liver Regeneration by Disturbing Lipid Droplet Triglyceride Turnover
Advanced Science, Volume 13, Issue 3, 14 January 2026.This study identifies CIDEC, an lipid droplet (LD)‐fusion associated protein upregulated by CREBH during early regeneration, as a negative regulator of liver regeneration through its unexpected role in sequestering triglyceride (TG) within LDs. CIDEC depletion reduces LD size, mobilizes LD‐stored TG, enhances TG catabolism and free fatty acid (FFA ...
Feng Ouyang +16 more
wiley +1 more source
Kidney triglyceride accumulation in the fasted mouse is dependent upon serum free fatty acids [PDF]
, 2017 Abumrad, Nada A. +2 more
core +2 more sources
A Robust Serum Proteomic Signature of the E2 Allele of Apolipoprotein E
Advanced Science, Volume 13, Issue 4, 19 January 2026.This study expands a serum protein signature of the e2 allele of APOE using multiple proteomic platforms and UK Biobank replication. The signature supports the role of APOE in lipid regulation through apolipoproteins and inflammation and includes, among others, neutrophil secreted granule proteins CAMP, CTSG, DEFA3, and MPO that point to inhibition of ...
Paola Sebastiani +20 more
wiley +1 more source
Short Communication: Identification of Two Polymorphisms in the Goat Lipoprotein Lipase Gene and Their Association with Milk Production Traits [PDF]
, 2007 Bouabid Badaoui +8 more
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Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels
Advanced Science, Volume 13, Issue 1, 5 January 2026.A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Xiaohan Liu +10 more
wiley +1 more source