Results 171 to 180 of about 80,622 (214)
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Lipoprotein lipase in diabetes
Diabetes/Metabolism Reviews, 1987Lipoprotein lipase has a central role in the metabolism of both triglyceride-rich particles and high density lipoproteins, and it is one determinant of both serum triglyceride and HDL concentrations. In man the enzyme activity in both adipose tissue and skeletal muscle is insulin dependent, and therefore it varies in diabetes according to ambient ...
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Lipaemia in lipoprotein lipase deficiency
Journal of Paediatrics and Child Health, 2016See ...
Anthony Liu +2 more
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Assay of an activator for lipoprotein lipase
Clinica Chimica Acta, 1976A method is described which enables the ability of human serum to activate guinea pig lipoprotein lipase to be measured in terms of an arbitrary standard. Evidence is offered which strongly suggests that the substance measured is also the activator of human lipoprotein lipase and observations on the relative levels of activator in human sera are given.
Peter Chu, A.L. Miller, G.L. Mills
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Atherosclerosis, 1975
Rat heart lipoprotein lipase was highly purified by affinity chromatography using heparin-Sepharose 4B. When extracts of acetone powder were applied to columns, lipase activity was firmly bound to the gel matrix and was later eluted with 1.5 M NaCl. At this stage the eluted enzyme was purified 1500-fold.
Jer-Shung Twu +5 more
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Rat heart lipoprotein lipase was highly purified by affinity chromatography using heparin-Sepharose 4B. When extracts of acetone powder were applied to columns, lipase activity was firmly bound to the gel matrix and was later eluted with 1.5 M NaCl. At this stage the eluted enzyme was purified 1500-fold.
Jer-Shung Twu +5 more
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Postheparin Lipoprotein Lipases
New England Journal of Medicine, 1975A heterogeneous group of enzymes, including hepatic and extrahepatic lipases, monoglyceride hydrolase, and phospholipase, are released into plasma after heparin injection, and may function in clear...
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Interaction of Lipoprotein Lipase with Heparina
Annals of the New York Academy of Sciences, 1989The hydrolysis of triglyceride-rich plasma lipoproteins is initiated by lipoprotein lipase (LPL) located at the luminal surface of endothelial cells. We previously reported that LPL binds to cultured endothelial cells with a Km of 2.7 x 10(-7) M and that this binding is inhibited by heparinase, heparin, or heparan sulfate.
Kazuhiro Oka +3 more
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Physiological regulation of lipoprotein lipase
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2014The enzyme lipoprotein lipase (LPL), originally identified as the clearing factor lipase, hydrolyzes triglycerides present in the triglyceride-rich lipoproteins VLDL and chylomicrons. LPL is primarily expressed in tissues that oxidize or store fatty acids in large quantities such as the heart, skeletal muscle, brown adipose tissue and white adipose ...
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Lipoprotein lipase in the physiological system
Biochemical Society Transactions, 1985Lipoprotein lipase (EC 3.1.1.34) cataly:%es the hydrolysis of plasma triacylglycerols and thereby enables the transfer of triacylglycerol fatty acids from the circulation to various extrahepatic tissues. The enzyme is synthesized in the parenchymal cells of a number of tissues including adipose tissue, heart and mammary gland, and is then secreted and ...
Donald S. Robinson +2 more
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A further characterization of lipoprotein lipase
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1968Abstract The isolation of hydrolysis products from glyceryl [1- 14 C]trioleate provided a sensitive and reproducible assay system to measure plasma post-heparin lipolytic activity and adipose tissue lipoprotein lipase (glycerol-ester hydrolase, EC 3.1.1.3). Essentially no lipolytic activity was detected in pre-heparin plasma.
Heiner Greten +2 more
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1993
Lipoprotein lipase (LPL) activity in cultured mesenchymal cells derived from new-born rat heart, increases during the final week after plating and then plateaus [1, 2]. Expression of LPL requires the presence of 20% serum and activity decreases markedly in serum-poor medium [3,4], Basic fibroblast growth factor (bFGF) plays an important role in cell ...
Gideon Friedman +2 more
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Lipoprotein lipase (LPL) activity in cultured mesenchymal cells derived from new-born rat heart, increases during the final week after plating and then plateaus [1, 2]. Expression of LPL requires the presence of 20% serum and activity decreases markedly in serum-poor medium [3,4], Basic fibroblast growth factor (bFGF) plays an important role in cell ...
Gideon Friedman +2 more
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