Results 1 to 10 of about 364,779 (302)
Lipoprotein metabolism in familial hypercholesterolemia [PDF]
Journal of Lipid Research, 2021 Familial hypercholesterolemia (FH) is one of the most common genetic disorders in humans. It is an extremely atherogenic metabolic disorder characterized by lifelong elevations of circulating LDL-C levels often leading to premature cardiovascular events.
Kévin Chemello +5 more
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Causal associations between disorders of lipoprotein metabolism and ten cardiovascular diseases [PDF]
Frontiers in Cell and Developmental Biology, 2022 Disorders of lipoprotein metabolism have been linked with an increased risk of cardiovascular diseases (CVDs) but the causal association is unclear. In this study, we investigated the causal association between disorders of lipoprotein metabolism and ...
Qiannan Gao +5 more
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A simplified procedure to trace triglyceride‐rich lipoprotein metabolism in vivo [PDF]
Physiological Reports, 2021 Glycerol tri[3H]oleate and [14C]cholesteryl oleate double‐labeled triglyceride‐rich lipoprotein (TRL)‐like particles are a well‐established tool to trace the effect of lipid‐modulating interventions on TRL metabolism.
Zhixiong Ying +4 more
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A Simple Fluorescent Cholesterol Labeling Method to Cryoprotect and Detect Plasma Lipoprotein-X
Biology, 2022 Lipoprotein-X (LpX) are abnormal nephrotoxic lipoprotein particles enriched in free cholesterol and phospholipids. LpX with distinctive lipid compositions are formed in patients afflicted with either familial LCAT deficiency (FLD) or biliary cholestasis.
Edward B. Neufeld +6 more
doaj +1 more source
Apolipoprotein Mimetic Peptides: Potential New Therapies for Cardiovascular Diseases
Cells, 2021 Since the seminal breakthrough of treating diabetic patients with insulin in the 1920s, there has been great interest in developing other proteins and their peptide mimetics as therapies for a wide variety of other medical disorders. Currently, there are
Anna Wolska +4 more
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Frontiers in Cardiovascular Medicine, 2023 IntroductionDefects in lipolysis can lead to hypertriglyceridemia, which can trigger acute pancreatitis and is also associated with cardiovascular disease.
Denis Sviridov +8 more
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A new phenotypic classification system for dyslipidemias based on the standard lipid panel
Lipids in Health and Disease, 2021 Highlights A new algorithm is described for categorizing dyslipidemic patients into Fredrickson-like lipoprotein phenotypes except for Type III. The new lipoprotein phenotypes were validated by NMR-lipoprotein analysis and by agarose gel electrophoresis ...
Maureen Sampson +15 more
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Transgelin: a new gene involved in LDL endocytosis identified by a genome-wide CRISPR-Cas9 screen
Journal of Lipid Research, 2022 A significant proportion of patients with elevated LDL and a clinical presentation of familial hypercholesterolemia do not carry known genetic mutations associated with hypercholesterolemia, such as defects in the LDL receptor.
Diego Lucero +14 more
doaj +1 more source
Journal of Lipid Research, 1988 The heterogeneity of serum lipoproteins (excluding very low density (VLDL) and intermediate density (IDL) lipoproteins) and that of lipoproteins secreted by HepG2 cells has been studied by immunoblot analysis of the apolipoprotein composition of the ...
C A Vézina +3 more
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Alterations of intestinal lipoprotein metabolism in diabetes mellitus and metabolic syndrome [PDF]
, 2015 Diabetes and metabolic syndrome are associated with abnormal postprandial lipoprotein metabolism, with a significant delay in the clearance of many lipid parameters, including triglycerides and chylomicrons.
ARCA, Marcello
core +1 more source