Interdependent Impact of Lipoprotein Receptors and Lipid-Lowering Drugs on HCV Infectivity [PDF]
Cells, 2021 The HCV replication cycle is tightly associated with host lipid metabolism: Lipoprotein receptors SR-B1 and LDLr promote entry of HCV, replication is associated with the formation of lipid-rich membranous organelles and infectious particle assembly ...
Francisco J. Zapatero-Belinchón +10 more
doaj +2 more sources
Lipoprotein Receptors Redundantly Participate in Entry of Hepatitis C Virus. [PDF]
PLoS Pathogens, 2016 Scavenger receptor class B type 1 (SR-B1) and low-density lipoprotein receptor (LDLR) are known to be involved in entry of hepatitis C virus (HCV), but their precise roles and their interplay are not fully understood. In this study, deficiency of both SR-
Satomi Yamamoto +14 more
doaj +2 more sources
Expanding functions of lipoprotein receptors
Journal of Lipid Research, 2009 Lipoprotein receptors are evolutionarily ancient proteins that are expressed on the surface of many cell types. Beginning with the appearance of the first primitive multicellular organisms, several structurally and functionally distinct families of ...
Joachim Herz +3 more
doaj +3 more sources
Characterization of the low-density lipoprotein receptors family and identification of vitellogenin receptors in Mugil cephalus [PDF]
Scientific ReportsVitellogenin receptors (VtgRs) are pivotal to the successful reproductive event in oviparous species by mediating the uptake of vitellogenin (Vtg) into developing oocytes, ensuring proper yolk formation and embryonic development.
Andrea Miccoli, Basilio Randazzo
doaj +2 more sources
New horizons for lipoprotein receptors: communication by β-propellers [PDF]
Journal of Lipid Research, 2013 The lipoprotein receptor (LR) family constitutes a large group of structurally closely related receptors with broad ligand-binding specificity. Traditionally, ligand binding to LRs has been anticipated to involve merely the complement type repeat (CR ...
Olav M. Andersen +2 more
doaj +2 more sources
Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival [PDF]
, 2017 LDL receptor-related proteins (LRPs) are transmembrane receptors involved in endocytosis, cell-signaling, and trafficking of other cellular proteins. Considerable work has focused on LRPs in the fields of vascular biology and neurobiology.
Gilder, Andrew S. +4 more
core +18 more sources
PCSK9 Functions in Atherosclerosis Are Not Limited to Plasmatic LDL-Cholesterol Regulation
Frontiers in Cardiovascular Medicine, 2021 The relevance of PCSK9 in atherosclerosis progression is demonstrated by the benefits observed in patients that have followed PCSK9-targeted therapies.
Aureli Luquero +5 more
doaj +1 more source
LRP1 loss in airway epithelium exacerbates smoke-induced oxidative damage and airway remodeling
Journal of Lipid Research, 2022 The LDL receptor-related protein 1 (LRP1) partakes in metabolic and signaling events regulated in a tissue-specific manner. The function of LRP1 in airways has not been studied. We aimed to study the function of LRP1 in smoke-induced disease.
Itsaso Garcia-Arcos +13 more
doaj +1 more source
Hepatitis C Virus Uses Host Lipids to Its Own Advantage
Metabolites, 2021 Lipids and lipoproteins constitute indispensable components for living not only for humans. In the case of hepatitis C virus (HCV), the option of using the products of our lipid metabolism is “to be, or not to be”. On the other hand, HCV infection, which
Malgorzata Sidorkiewicz
doaj +1 more source
Liver Transplantation to Provide Low-Density-Lipoprotein Receptors and Lower Plasma Cholesterol in a Child with Homozygous Familial Hypercholesterolemia [PDF]
, 1984 A six-year-old girl with severe hypercholesterolemia and atherosclerosis had two defective genes at the low-density-lipoprotein (LDL) receptor locus, as determined by biochemical studies of cultured fibroblasts.
Cummings +9 more
core +1 more source