The Current Status of Research on High-Density Lipoproteins (HDL): A Paradigm Shift from HDL Quantity to HDL Quality and HDL Functionality. [PDF]
Int J Mol Sci, 2022 The quantity of high-density lipoproteins (HDL) is represented as the serum HDL-C concentration (mg/dL), while the HDL quality manifests as the diverse features of protein and lipid content, extent of oxidation, and extent of glycation. The HDL functionality represents several performance metrics of HDL, such as antioxidant, anti-inflammatory, and ...
Cho KH.
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The pleiotropic vasoprotective functions of high density lipoproteins (HDL). [PDF]
J Biomed Res, 2017 The pleiotropic functions of circulating high density lipoprotein (HDL) on peripheral vascular health are well established. HDL plays a pivotal role in reverse cholesterol transport and is also known to suppress inflammation, endothelial activation and apoptosis in peripheral vessels.
Boyce G, Button E, Soo S, Wellington C.
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Microencapsulated Pomegranate Modifies the Composition and Function of High-Density Lipoproteins (HDL) in New Zealand Rabbits [PDF]
Molecules, 2020 Previous studies demonstrated that pomegranate, which is a source of several bioactive molecules, induces modifications of high-density lipoproteins (HDL) lipid composition and functionality.
Alan Dorantes-Morales +9 more
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Suppression of Endothelial Cell Apoptosis by High Density Lipoproteins (HDL) and HDL-associated Lysosphingolipids [PDF]
Journal of Biological Chemistry, 2001 Apoptotic cell death following injury of vascular endothelium is assumed to play an important role in the pathogenesis of atherosclerosis. In this report, we demonstrate that high density lipoproteins (HDL), a major anti-atherogenic lipoprotein fraction, protect endothelial cells against growth factor deprivation-induced apoptosis.
J R, Nofer +7 more
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Adsorption of High Density Lipoproteins (HDL) on Solid Surfaces [PDF]
Journal of Colloid and Interface Science, 1996 The adsorption of high density lipoproteins (HDL) on polyethylene (PE), poly(2-hydroxyethyl methacrylate) (poly(HEMA)), polyesterurethane (PU), Biomer, and mica surfaces was studied. The adsorption of HDL from a single protein solution and a plasma solution on the surfaces showed that the amount of adsorbed HDL was not related to the hydrophobicity (or
Feng, Minhua +7 more
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Native High-Density Lipoproteins (HDL) with Higher Paraoxonase Exerts a Potent Antiviral Effect against SARS-CoV-2 (COVID-19), While Glycated HDL Lost the Antiviral Activity. [PDF]
Antioxidants (Basel), 2021 Human high-density lipoproteins (HDL) show a broad spectrum of antiviral activity in terms of anti-infection. Although many reports have pointed out a correlation between a lower serum HDL-C and a higher risk of COVID-19 infection and progression, the in
Cho KH, Kim JR, Lee IC, Kwon HJ.
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Associations between lipoproteins and risk of ischemic stroke: a systematic review and meta-analysis of Mendelian randomization studies [PDF]
Frontiers in NeurologyObjectiveTo systematically evaluate the causal effects of lipoproteins on ischemic stroke (IS) through a systematic review and meta-analysis of Mendelian randomization (MR) studies.MethodsA comprehensive literature search was conducted in PubMed, Embase,
Yanwei Guo +9 more
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Loss of sphingosine 1-phosphate (S1P) in septic shock is predominantly caused by decreased levels of high-density lipoproteins (HDL). [PDF]
J Intensive Care, 2019 BackgroundSphingosine 1-phosphate (S1P) is a signaling lipid essential in regulating processes involved in sepsis pathophysiology, including endothelial permeability and vascular tone. Serum S1P is progressively reduced in sepsis patients with increasing
Winkler MS +6 more
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High-Density Lipoprotein (HDL) Triglyceride and Oxidized HDL: New Lipid Biomarkers of Lipoprotein-Related Atherosclerotic Cardiovascular Disease [PDF]
Antioxidants, 2020 Lipid markers are well-established predictors of vascular disease. The most frequently measured lipid markers are total cholesterol, high-density lipoprotein (HDL)-cholesterol (HDL-C), LDL cholesterol (LDL-C), and triglyceride. HDL reduces atherosclerosis by multiple mechanisms, leading to a reduced risk of cardiovascular disease, and HDL-C, as a ...
Fumiaki Ito, Tomoyuki Ito
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Nonlinear dynamics of early atherosclerotic plaque formation may determine the efficacy of high density lipoproteins (HDL) in plaque regression. [PDF]
PLoS One, 2017 We use a computational model to explore the effect of foam cell accumulation on plaque regression following an increase in high density lipoprotein (HDL) influx into the plaque.
Chalmers AD, Bursill CA, Myerscough MR.
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