Results 61 to 70 of about 87,754 (241)

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

Relationship Between Physical Conditioning and Plasma High Density Lipoprotein-Cholesterol Concentration [PDF]

, 1983
Five subjects (three females and two males) took part in an exercise regimen in order to determine if aerobic exercise results in an increase in high-density lipoprotein-cholesterol levels (HDL-C) in the plasma.
Baeyens, Dennis A., Morgans, Leland F., Morris, Manford D.   +2 more
core   +2 more sources

Apolipoprotein E and Atherosclerosis: From Lipoprotein Metabolism to MicroRNA Control of Inflammation. [PDF]

, 2018
Apolipoprotein (apo) E stands out among plasma apolipoproteins through its unprecedented ability to protect against atherosclerosis. Although best recognized for its ability to mediate plasma lipoprotein clearance in the liver and protect against ...
Hasty, Hui, Hussain, Lin, Mahley, Pepe, Roselaar   +6 more
core   +2 more sources

Adverse Cardiovascular Risk Profile and Increased Diurnal Salivary Cortisol in Girls With Turner Syndrome: An Exploratory Study

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Patients with Turner Syndrome (TS) and those exposed to high concentrations of glucocorticoids have a number of characteristics in common, including an increased risk of cardiovascular disease. Pediatric TS patients underwent studies of salivary cortisol (SC) and cortisone (SCn), body composition, continuous glucose monitoring, vascular ...
Lily Jones, Julie Park, Silothabo Dliso, Daniel B. Hawcutt, Alena Shantsila, Gregory Y. H. Lip, Joanne Blair   +6 more
wiley   +1 more source

Urinary cholesterol: its association with a macromolecular protein- lipid complex [PDF]

, 1984
The cholesterol-containing complexes in the urine of normal subjects and patients with diseases accompanied by hyperexcretion of urinary cholesterol were characterized. In normal subjects, the major portion of the recovered urinary cholesterol was eluted
Jüngst, Dieter, Karl, Hans Josef, Siess, E., Weiser, H.   +3 more
core  

Primary hepatocytes as targets for hepatitis C virus replication [PDF]

, 2008
Much of our current understanding of hepatitis C virus (HCV) replication has hailed from the use of a small number of cloned viral genomes and transformed hepatoma cell lines.
Agnello, Andre, Andreo, Bartenschlager, Bartosch, Bartosch, Bartosch, Basu, Bertaux, Castet, Catanese, Chang, Cocquerel, Codran, Decaens, Diaz, Dreux, Evans, Flint, Fournier, Furuse, Gastaminza, Grove, Harder, Harris, Hsu, Huang, Kanda, Kapadia, Krieger, Lazaro, Levy, Lindenbach, Lindenbach, Maillard, Martin, McCaughan, Mee, Meertens, Mercer, Meuleman, Meunier, Moghe, Molina, Molina, Morikawa, Nielsen, Nielsen, Olenina, Pileri, Prince, Reynolds, Scarselli, Silver, Thomssen, Timpe, Vinken, Voisset, Wakita, Wang, Wunschmann, Yang, Zeisel, Zhang, Zheng, Zhong   +65 more
core   +2 more sources

A hepatoprotective experiment on taro vegetable (Colocasia esculenta (L.) Schott) flower employing animal models by mitigating oxidative stress

Animal Models and Experimental Medicine, EarlyView.
The antioxidant efficacy of Colocasia esculenta flower’s methanolic extract was assessed using 2,2′‐azino‐bis‐(3‐ethylbenzothiazoline‐6‐sulfonic) (ABTS) and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) scavenging assay. The hepatoprotective effect was investigated by assessing liver injury indicators (amino transferase [ALT], aspartate amino transferase [AST],
Mahathir Mohammad, Fahmida Tasnim Richi, Rabiul Hossain, Md. Arafat, Pair Ahmed Jiko, Nazim Uddin Emon, Sayed Al Hossain Rabbi, Tirtha Khastagir, Md. Hemayet Hossain, Safaet Alam   +9 more
wiley   +1 more source

Genetic obesity increases pancreatic expression of mitochondrial proteins which regulate cholesterol efflux in BRIN-BD11 insulinoma cells [PDF]

, 2019
Pancreatic β-cells are sensitive to fluctuations in cholesterol content, which can damage the insulin secretion pathway, contributing to the aetiology of type 2 diabetes mellitus.
Caridis, Anna Maria, Dolan, Sharron, Graham, Annette, Lightbody, Richard J., Tarlton, Jamie M.R.   +4 more
core   +1 more source

Metabolomic analysis reveals the molecular mechanism related to leg abnormality in broilers

Animal Research and One Health, EarlyView.
The graphical abstract shows the principal results of this study. Compared to the leg normal broilers, the serum calcium to phosphorus ratio was extremely decreased in the group with deformed leg bones. Additionally, a total of nine differential metabolites significantly associated with leg abnormalities and serum calcium and phosphorus levels were ...
Jumei Zheng, Qi Zhang, Xinxin Tang, Fan Ying, Dawei Liu, Sen Li, Ranran Liu, Jie Wen, QingHe Li, Guiping Zhao   +9 more
wiley   +1 more source

The regulation of miRNAs by reconstituted high-density lipoproteins in diabetes-impaired angiogenesis [PDF]

, 2018
Diabetic vascular complications are associated with impaired ischaemia-driven angiogenesis. We recently found that reconstituted high-density lipoproteins (rHDL) rescue diabetes-impaired angiogenesis.
Bursill, Christina A., Clayton, Zoe E., Henriquez, Rodney, Hourigan, Samuel T., Nankivell, Victoria A., Ng, Martin K.C., Nicholls, Stephen J., Ridiandries, Anisyah, Robertson, Stacy, Solly, Emma L., Tan, Joanne T.M., Tepper, Edward R., Tsatralis, Tania, Vanags, Laura Z., Weimann, Benjamin M., Zhang, Jennifer Q.J.   +15 more
core   +2 more sources