Results 41 to 50 of about 4,241 (120)

Pharmacological properties of a novel ACAT inhibitor (CP-113,818) in cholesterol-fed rats, hamsters, rabbits, and monkeys

Journal of Lipid Research, 1994
The novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor CP-113,818 has been characterized in vitro against ACAT isolated from liver and intestine from a variety of species including human subjects, and in vivo in cholesterol-fed rats, hamsters ...
C A Marzetta, Y E Savoy, A M Freeman, C A Long, J L Pettini, R E Hagar, P B Inskeep, K Davis, A F Stucchi, R J Nicolosi   +9 more
doaj   +1 more source

The role of different albumin preparations on production of human plasma lipoprotein-like particles in vitro

Journal of Lipid Research, 1980
Because we found apoprotein contamination of some high-grade commercial albumins, we studied this effect on formation of lipoprotein-like particles during lipolysis of human very low density lipoprotein (VLDL) in vitro.
R J Deckelbaum, T Olivecrona, M Fainaru
doaj   +1 more source

Effects of insulin on plasma lipoproteins in diabetic ketoacidosis: evidence for a change in high density lipoprotein composition during treatment.

Journal of Lipid Research, 1982
To determine the acute effects of insulin on lipoprotein metabolism, we have followed the plasma lipoprotein lipid and apolipoprotein levels during insulin therapy for the first 24 hr in 13 patients with diabetic ketoacidosis.
S W Weidman, J B Ragland, J N Fisher, Jr, A E Kitabchi, S M Sabesin   +4 more
doaj   +1 more source

Conversion of plasma VLDL and IDL precursors into various LDL subpopulations using density gradient ultracentrifugation.

Journal of Lipid Research, 1990
The contribution of very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) to various low density lipoprotein (LDL) subfractions was examined in three normal subjects and two with familial combined hyperlipidemia.
CA Marzetta, DM Foster, JD Brunzell
doaj   +1 more source

Metabolsim of apoB and apoC lipoproteins in man: kinetic studies in normal and hyperlipoproteininemic subjects

Journal of Lipid Research, 1978
The kinetics of apolipoproteins B and C were studied in 14 normal and hyperlipoproteinemic subjects after injection of exogenously 125I-labeled very low density lipoprotein (VLDL) particles.
M Berman, Ph.D., M Hall, III, R I Levy, S Eisenberg, D W Bilheimer, R D Phair, R H Goebel   +6 more
doaj   +1 more source

Metabolic pathways of apolipoprotein B in heterozygous familial hypercholesterolemia: studies with a [3H]leucine tracer.

Journal of Lipid Research, 1991
The kinetics of apolipoprotein B (apoB) were measured in seven studies in heterozygous, familial hypercholesterolemic subjects (FH) and in five studies in normal subjects, using in vivo tracer kinetic methodology with a [3H]leucine tracer.
WR Fisher, LA Zech, LL Kilgore, PW Stacpoole   +3 more
doaj   +1 more source

Studies on the metabolism of apolipoprotein B in hypertriglyceridemic subjects using simultaneous administration of tritiated leucine and radioiodinated very low density lipoprotein.

Journal of Lipid Research, 1990
To study the metabolic pathways of apolipoprotein B (apoB), a series of studies were carried out in which both radioiodinated very low density lipoproteins (VLDL) and tritiated leucine were simultaneously injected into three hypertriglyceridemic subjects.
WF Beltz, YA Kesäniemi, NH Miller, WR Fisher, SM Grundy, LA Zech   +5 more
doaj   +1 more source

Apolipoprotein B metabolism in homozygous familial hypercholesterolemia.

Journal of Lipid Research, 1989
This report describes the metabolism of apolipoprotein B-containing lipoproteins in seven familial hypercholesterolemic (FH) homozygotes and compares the results to the values obtained from five healthy control subjects.
R W James, B Martin, D Pometta, J C Fruchart, P Duriez, P Puchois, J P Farriaux, A Tacquet, T Demant, R J Clegg   +9 more
doaj   +1 more source

Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopy[S]

Journal of Lipid Research, 2011
Plasma lipoprotein levels are predictors of risk for coronary artery disease. Lipoprotein structure-function relationships provide important clues that help identify the role of lipoproteins in cardiovascular disease. The compositional and conformational
Lei Zhang, James Song, Giorgio Cavigiolio, Brian Y. Ishida, Shengli Zhang, John P. Kane, Karl H. Weisgraber, Michael N. Oda, Kerry-Anne Rye, Henry J. Pownall, Gang Ren   +10 more
doaj   +1 more source

Distinct patterns of lipoproteins with apoB defined by presence of apoE or apoC-III in hypercholesterolemia and hypertriglyceridemia

Journal of Lipid Research, 2001
Apolipoprotein (apo) E and apoC-III concentrations in VLDL and LDL are associated with coronary heart disease. We studied the relationship between apoE and apoC-III and the abnormal concentrations and distribution of apoB lipoproteins in 10 ...
Hannia Campos, Dan Perlov, Christina Khoo, Frank M. Sacks   +3 more
doaj   +1 more source