Results 1 to 10 of about 503,423 (233)

Fluid-structure interactions (FSI) based study of low-density lipoproteins (LDL) uptake in the left coronary artery. [PDF]

Sci Rep, 2021
The purpose of this study is to compare the effect of the different physical factors on low-density lipoproteins (LDL) accumulation from flowing blood to the arterial wall of the left coronary arteries.
Chen X, Zhuang J, Huang H, Wu Y.
europepmc   +2 more sources

Approaches to Visualising Endocytosis of LDL-Related Lipoproteins [PDF]

Biomolecules, 2022
Endocytosis is the process by which molecules are actively transported into cells. It can take on a variety of forms depending on the cellular machinery involved ranging from specific receptor-mediated endocytosis to the less selective and actin-driven macropinocytosis.
Halima Siddiqui, Nikita Yevstigneyev, Golnoush Madani, Sally McCormick   +3 more
openaire   +3 more sources

Native and oxidised lipoproteins negatively regulate the serum amyloid A‐induced NLRP3 inflammasome activation in human macrophages

Clinical & Translational Immunology, 2021
Objectives The NLRP3 inflammasome plays a key role in arterial wall inflammation. In this study, we elucidated the role of serum lipoproteins in the regulation of NLRP3 inflammasome activation by serum amyloid A (SAA) and other inflammasome activators ...
Katariina Nurmi, Katri Niemi, Ilona Kareinen, Kristiina Silventoinen, Martina B Lorey, Yan Chen, Vesa‐Petteri Kouri, Jukka Parantainen, Timo Juutilainen, Katariina Öörni, Petri T Kovanen, Dan Nordström, Sampsa Matikainen, Kari K Eklund   +13 more
doaj   +1 more source

Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia

Molecular Neurodegeneration, 2023
This narrative review focuses on the role of cholesteryl ester transfer protein (CETP) and peripheral lipoproteins in the vascular contributions to cognitive impairment and dementia (VCID).
Tetiana Poliakova, Cheryl L. Wellington
doaj   +1 more source

Protein S on the surface of plasma lipoproteins: a potential mechanism for protein S delivery to the atherosclerotic plaques?

Bleeding, Thrombosis and Vascular Biology, 2022
The anticoagulant protein S (PS) binds phospholipids with very high affinity, but PS interaction with lipoproteins and lipidrich atherosclerotic plaques remains still poorly defined.
Marcello Baroni, Paolo Ferraresi, Nicole Ziliotto, Daria Bortolotti, Pierfilippo Acciarri, Nicola Martinelli, Giovanna Marchetti, Matteo Coen, Francesco Bernardi   +8 more
doaj   +1 more source

Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies—a consensus statement from the European Atherosclerosis Society

European Heart Journal, 2021
Recent advances in human genetics, together with a large body of epidemiologic, preclinical, and clinical trial results, provide strong support for a causal association between triglycerides (TG), TG-rich lipoproteins (TRL), and TRL remnants, and ...
H. Ginsberg, C. Packard, M. Chapman, J. Borén, C. Aguilar-Salinas, M. Averna, B. Ference, D. Gaudet, R. Hegele, S. Kersten, G. Lewis, A. Lichtenstein, P. Moulin, B. Nordestgaard, A. Remaley, B. Staels, E. Stroes, M. Taskinen, L. Tokgözoğlu, A. Tybjaerg-hansen, Jane K. Stock, A. Catapano   +21 more
semanticscholar   +1 more source

Molecular and Cellular Mechanisms of Electronegative Lipoproteins in Cardiovascular Diseases

Biomedicines, 2020
Dysregulation of glucose and lipid metabolism increases plasma levels of lipoproteins and triglycerides, resulting in vascular endothelial damage. Remarkably, the oxidation of lipid and lipoprotein particles generates electronegative lipoproteins that ...
Liang-Yin Ke, Shi Hui Law, Vineet Kumar Mishra, Farzana Parveen, Hua-Chen Chan, Ye-Hsu Lu, Chih-Sheng Chu   +6 more
doaj   +1 more source

Atherosclerosis Calcification: Focus on Lipoproteins

Metabolites, 2023
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids in the vessel wall, leading to the formation of an atheroma and eventually to the development of vascular calcification (VC).
Jaap G. Neels, Georges Leftheriotis, Giulia Chinetti   +2 more
doaj   +1 more source

Association of Apolipoprotein B-Containing Lipoproteins and Risk of Myocardial Infarction in Individuals With and Without Atherosclerosis: Distinguishing Between Particle Concentration, Type, and Content.

JAMA cardiology, 2021
Importance Lipid management typically focuses on levels of low-density lipoprotein cholesterol (LDL-C) and, to a lesser extent, triglycerides (TG). However, animal models and genetic studies suggest that the atherogenic particle subpopulations (LDL and ...
N. Marston, R. Giugliano, G. Melloni, Jeong-Gun Park, Valerie N. Morrill, M. Blazing, B. Ference, Evan Stein, E. Stroes, E. Braunwald, P. Ellinor, S. Lubitz, C. Ruff, M. Sabatine   +13 more
semanticscholar   +1 more source

LRP6 Protein Regulates Low Density Lipoprotein (LDL) Receptor-mediated LDL Uptake [PDF]

Journal of Biological Chemistry, 2012
Genetic variations in LRP6 gene are associated with high serum LDL cholesterol levels. We have previously shown that LDL clearance in peripheral B-lymphocytes of the LRP6(R611C) mutation carriers is significantly impaired. In this study we have examined the role of wild type LRP6 (LRP6(WT)) and LRP6(R611C) in LDL receptor (LDLR)-mediated LDL uptake ...
Zhi-jia, Ye, Gwang-Woong, Go, Rajvir, Singh, Wenzhong, Liu, Ali Reza, Keramati, Arya, Mani   +5 more
openaire   +2 more sources