Results 221 to 230 of about 66,086 (315)

Lipid Profile in Primary Aldosteronism: Cross‐Sectional and Post‐Treatment Analyses

open access: yesLipids, EarlyView.
ABSTRACT The relationship between primary aldosteronism (PA) and lipid metabolism remains controversial, with inconsistent findings reported in the literature. This study aimed to clarify PA's impact on the lipid profile using both a cross‐sectional comparison with essential hypertension (EH) controls and a longitudinal within‐patient pre‐post ...
Meriem Yazidi   +7 more
wiley   +1 more source

Impact of Heated Versus Unheated Cooking Oil on Postprandial Vascular Function and Metabolism

open access: yesLipids, EarlyView.
ABSTRACT The impact of repeated heating of seed‐based culinary oils on cardiometabolic health has not been well established. Heating oils to high temperatures (> 150°C) causes lipid peroxidation, thus generating potentially harmful compounds that may impair vascular function. This randomized, single‐blind, crossover study investigated the acute effects
Rosiered Brownson‐Smith   +5 more
wiley   +1 more source

Melatonin Promotes Improvement in Serum Lipid Levels and Liver Histopathology in Hyperlipidemic Rats

open access: yesLipids, EarlyView.
ABSTRACT Hyperlipidemia or dyslipidemia is the term used for the increase in lipid levels in blood plasma, usually occurring due to a high‐fat diet associated with a sedentary lifestyle. The increase in lipid levels can cause fatty infiltration in the liver known as hepatic steatosis, which can lead to inflammation, fibrosis, and necrosis consecutively.
Ana Cláudia Carvalho de Sousa   +9 more
wiley   +1 more source

Mapping Causal Biology: Mendelian Randomization in the Era of Big Data

open access: yesMed Research, EarlyView.
Mendelian randomization (MR) leverages genetic variants to mitigate confounding biases in causal inference. This review systematically maps MR's methodological evolution, highlights its expanding applications in epidemiology and drug target validation, and outlines future directions for overcoming current biases through dynamic, multi‐omics, and cross ...
Xuanlu Shen   +10 more
wiley   +1 more source

Unraveling the Shared Genetic Architecture and Molecular Mechanisms Linking Cardiovascular Traits and Glaucoma: A Comprehensive Cross‐Trait Analysis

open access: yesMedicine Advances, EarlyView.
This study investigates the shared genetic architecture between eight cardiovascular traits and glaucoma using comprehensive cross‐trait analysis. We identified 9948 pleiotropic loci, 71 colocalized signals, and 24 shared genes, with BCAS3, BICC1, FAM213A, ITGB5, NUP160, and TNS1 emerging as robust cross‐trait candidates.
Junfei Huang   +8 more
wiley   +1 more source

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