Results 231 to 240 of about 66,086 (315)

Effectiveness and Safety of Setmelanotide in a Patient With a Heterozygous PCSK1 Deficiency

Obesity, EarlyView.
ABSTRACT Setmelanotide, a melanocortin 4 receptor (MC4R) agonist, is a promising pharmacological treatment option for people with rare monogenic obesity conditions affecting the leptin‐melanocortin signaling pathway, including proprotein convertase subtilisin/kexin type 1 (PCSK1) gene mutations.
Ellina Lytvyak, Arshdeep Rattol, Eduardo Grunvald   +2 more
wiley   +1 more source

Automated Cryo-EM and Supervised Machine Learning Enable Reproducible Characterization of Extracellular Vesicles and Co-Isolating Particles. [PDF]

J Extracell Vesicles
Enciso-Martinez A, Faas FGA, de Jong AWM, van Leeuwen TG, Nieuwland R, van der Pol E, Ten Dijke P, Koning RI.   +7 more
europepmc   +1 more source

Musculoskeletal Outcomes of Glucagon‐Like Peptide‐1 Receptor Agonists Versus Other Antiobesity Agents in Nondiabetic Adults

Obesity, EarlyView.
ABSTRACT Objective This study aimed to evaluate the association of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) with risks of osteoporosis, major osteoporotic fractures, and degenerative musculoskeletal disorders in nondiabetic adults with obesity compared with other obesity medications.
Jie‐Syuan Wu, Lee‐Yuan Lin, Jia‐Wei Sun, Wei‐Ting Yu, Fara Silvia Yuliani, Shyh‐Hsiang Lin   +5 more
wiley   +1 more source

The Past, Present, and Future of Dyslipidemia: A Narrative Review. [PDF]

Cureus
Manoria PC.
europepmc   +1 more source

Evidence map and gap analysis of metabolic change in pediatric growth hormone deficiency treated with growth hormone

Pediatric Investigation, EarlyView.
This evidence map of 63 studies (n = 6158) showed growth hormone therapy in children with growth hormone deficiency has neutral glucose effects, mixed lipid outcomes, potential benefits for bone mineral density, bone mineral content, and parathyroid hormone, but generally no impact on thyroid function, body composition, or body mass index.
Wei Wu, Ningyi Song, Yue Zhao, Caiqi Du, Yuning Zhao, You Wu, Xiaoping Luo   +6 more
wiley   +1 more source

In Situ Lipoprotein-seeking Dye for in Vivo Real-Time Imaging of Lipid Dysregulation Diseases. [PDF]

Adv Sci (Weinh)
Du Y, Dang Z, Xu B, Xu J, Wang D, Zhang Y, Zhu S.   +6 more
europepmc   +1 more source

Head‐to‐Head Comparison of Four Ultrasound Elastography Techniques in Detecting Advanced Fibrosis

Portal Hypertension &Cirrhosis, EarlyView.
Elastography is an important noninvasive method for diagnosing advanced fibrosis (AF); however, evidence remains insufficient, particularly regarding acoustic radiation force impulse (ARFI) techniques. This prospective mulitcenter study concludes that vibration controlled transient elastography (VCTE) demonstrates superior diagnostic performance to ...
Jiahao Han, Lichen Chu, Lixin Yang, Kexin Lou, Guangbin Dou, Huiming Shen, Xiaojun Cheng, Zuowei Bao, Jia Li   +8 more
wiley   +1 more source

Relationships Between Circulating Lipids, Lipoproteins, and Lymphocyte Subsets in the Multi-Ethnic Study of Atherosclerosis. [PDF]

Glob Heart
DeConne TM, Sitlani CM, Delaney JA, Psaty BM, Doyle MF, Otvos JD, Feinstein MJ, Olson NC.   +7 more
europepmc   +1 more source

Modeling of Disease Progression of Type 2 Diabetes Using Real‐World Data: Quantifying Competing Risks of Morbidity and Mortality

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 606-615, March 2025.
ABSTRACT Type 2 diabetes (T2D) is a progressive metabolic disorder that could be an underlying cause of long‐term complications that increase mortality. The assessment of the probability of such events could be essential for mortality risk management. This work aimed to establish a framework for risk predictions of macrovascular complications (MVC) and
Hanna Kunina, Stefan Franzén, Maria C. Kjellsson   +2 more
wiley   +1 more source