Results 101 to 110 of about 191,701 (337)

Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract

open access: yesCancer Communications, Volume 42, Issue 12, Page 1367-1386, December 2022., 2022
Abstract Background Neuroendocrine carcinomas of the gastrointestinal tract (GI‐NECs) remain a disease of grim prognosis with limited therapeutic options. Their molecular characteristics are still undefined. This study aimed to explore the underlying genetic basis and heterogeneity of GI‐NECs.
Huanwen Wu   +13 more
wiley   +1 more source

Abdominal Obesity, Dyslipidemia and Blood Pressure

open access: yesRevista Finlay, 2015
Fat stored in the abdominal region is resistant to insulin, increased degradation of triglycerides to fatty acids. The increased availability of fatty acids in the liver favors the formation of very low density lipoproteins and the resulting ...
Pedro Enrique Miguel Soca
doaj   +2 more sources

Heterogeneity of human very low density lipoproteins by gel filtration chromatography

open access: yesJournal of Lipid Research, 1972
Very low density lipoproteins were separated by gel filtration on Sepharose 4B. A decrease in mean particle diameter and flotation rate was seen with increasing elution volumes.
Steven H. Quarfordt   +3 more
doaj  

Physical activity, cardiorespiratory fitness, dietary content, and risk factors that cause a predisposition towards cardiovascular disease

open access: yesArquivos Brasileiros de Cardiologia, 2001
OBJECTIVE: To analyze associations between levels of physical activity, cardiorespiratory fitness, dietary content, and risk factors that cause a predisposition towards cardiovascular disease.
Dartagnan Pinto Guedes   +1 more
doaj   +1 more source

Bayesian modelling for binary outcomes in the Regression Discontinuity Design [PDF]

open access: yesarXiv, 2016
The Regression Discontinuity (RD) design is a quasi-experimental design which emulates a randomised study by exploiting situations where treatment is assigned according to a continuous variable as is common in many drug treatment guidelines. The RD design literature focuses principally on continuous outcomes.
arxiv  

Decoding Blastocystis‐Driven Mechanisms in Gut Microbiota and Host Metabolism

open access: yesAdvanced Science, EarlyView.
Blastocystis, a prevalent gut microbe, interacts with the host through metabolic and immune pathways, influencing cardiometabolic health. This perspective explores its role in modulating short‐chain fatty acid production, tryptophan metabolism, and immune signaling, potentially impacting cholesterol absorption, glucose metabolism, and vascular health ...
Lei Deng, Kevin SW Tan
wiley   +1 more source

Lipoprotein metabolism in the suckling rat: characterization of plasma and lymphatic lipoproteins.

open access: yesJournal of Lipid Research, 1983
Suckling rat plasma contains (in mg/dl): chylomicrons (85 +/- 12); VLDL (50 +/- 6); LDL (200 +/- 23); HDL1 (125 +/- 20); and HDL2 (220 +/- 10), while lymph contains (in mg/dl): chylomicrons (9650 +/- 850) and VLDL (4570 +/- 435) and smaller amounts of ...
G J Fernando-Warnakulasuriya   +3 more
doaj  

Contextualizing selection bias in Mendelian randomization: how bad is it likely to be? [PDF]

open access: yesarXiv, 2018
Selection bias affects Mendelian randomization investigations when selection into the study sample depends on a collider between the genetic variant and confounders of the risk factor-outcome association. However, the relative importance of selection bias for Mendelian randomization compared to other potential biases is unclear.
arxiv  

RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development

open access: yesAdvanced Science, EarlyView.
The study investigates the role of RACK7 in brain development using a conditional knockout mouse model. RACK7 deficiency results in developmental defects and abnormal astrocyte development by disrupting H3K27me3 chromatin binding. The underlying mechanism involves RACK7 interacting with the PRC2 complex to regulate the genomic localization of SUZ12 and
Fangfang Jiao   +9 more
wiley   +1 more source

Measurement of apolipoprotein B radioactivity in whole blood plasma by precipitation with isopropanol.

open access: yesJournal of Lipid Research, 1988
A method to measure apolipoprotein B radioactivity in whole blood plasma is described that is suitable for routine use in kinetic experiments in vivo.
N Yamada, R J Havel
doaj  

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